Zobrazeno 1 - 10
of 330
pro vyhledávání: '"Richard D. Wood"'
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2022)
DNA polymerases catalyze nucleotidyl transfer, the central reaction in synthesis of DNA polynucleotide chains. They function not only in DNA replication, but also in diverse aspects of DNA repair and recombination. Some DNA polymerases can perform tr
Externí odkaz:
https://doaj.org/article/d2f018ed6e81486c93cf59ad46c21ad4
Autor:
Wanjuan Feng, Dennis A. Simpson, Juan Carvajal-Garcia, Brandon A. Price, Rashmi J. Kumar, Lisle E. Mose, Richard D. Wood, Naim Rashid, Jeremy E. Purvis, Joel S. Parker, Dale A. Ramsden, Gaorav P. Gupta
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Polymerase theta is a widely conserved DNA polymerase that mediates Theta Mediated End Joining. Here authors present a synthetic lethal CRISPR screen to identify DDR gene mutations that induce cellular addiction to Pol theta.
Externí odkaz:
https://doaj.org/article/566f9084f7004b948bfb7d7d81816fbb
Publikováno v:
Cell Reports, Vol 34, Iss 8, Pp 108775- (2021)
Summary: In mammalian cells, specialized DNA polymerase ζ (pol ζ) contributes to genomic stability during normal DNA replication. Disruption of the catalytic subunit Rev3l is toxic and results in constitutive chromosome damage, including micronucle
Externí odkaz:
https://doaj.org/article/cee3193fab0c4fb1929c9738b6059c41
Many processes in materials science and engineering, such as the load deformation behaviour of certain structures, exhibit nonlinear characteristics. The computer simulation of such processes therefore requires a deep understanding of both the theore
Autor:
Richard D, Wood, Sylvie, Doublié
Publikováno v:
Annual Review of Genetics. 56:207-228
DNA polymerase θ (Pol θ) is a DNA repair enzyme widely conserved in animals and plants. Pol θ uses short DNA sequence homologies to initiate repair of double-strand breaks by theta-mediated end joining. The DNA polymerase domain of Pol θ is at th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f425c0e0a88ae9f1d89b2ecee7231aab
https://doi.org/10.1146/annurev-genet-072920-041046
https://doi.org/10.1146/annurev-genet-072920-041046
An essential resource for all scientists researching cellular responses to DNA damage.
Autor:
William Plunkett, Walter N. Hittelman, Richard D. Wood, Chaomei Liu, Billie Nowak, Kei-ichi Takata, Yingjun Jiang, Xiaojun Liu
Supplemental Figure S6 shows time-lapse video microscopy of lung cancer H460 cells after washout of CNDAC.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033cf1546c631fee20bb58010474b735
https://doi.org/10.1158/1535-7163.22506760
https://doi.org/10.1158/1535-7163.22506760
Autor:
William Plunkett, Walter N. Hittelman, Richard D. Wood, Chaomei Liu, Billie Nowak, Kei-ichi Takata, Yingjun Jiang, Xiaojun Liu
Supplemental Table S1 shows increase in multinucleate cells after washout of CNDAC - a 15-hr schedule.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4727b778c273264f7385cc00528e1e65
https://doi.org/10.1158/1535-7163.22506751
https://doi.org/10.1158/1535-7163.22506751
Autor:
William Plunkett, Walter N. Hittelman, Richard D. Wood, Chaomei Liu, Billie Nowak, Kei-ichi Takata, Yingjun Jiang, Xiaojun Liu
Incorporation of the clinically active deoxycytidine analogue 2′-C-cyano-2′-deoxy-1-β-D-arabino-pentofuranosyl-cytosine (CNDAC) into DNA generates single-strand breaks that are subsequently converted to double-strand breaks (DSB). Here, we inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59d3a84ba2940ffaad5e1d78b8c533f5
https://doi.org/10.1158/1535-7163.c.6538486.v1
https://doi.org/10.1158/1535-7163.c.6538486.v1
Autor:
Richard D. Wood, Donna F. Kusewitt, Lisa J. Robinson, Veronika Glushets, Vaishali Patil, John P. Wittschieben
Supplementary Figure 1 from Loss of DNA Polymerase ζ Enhances Spontaneous Tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b2ccc2ac9038d2492c3e998c25e940d
https://doi.org/10.1158/0008-5472.22386351.v1
https://doi.org/10.1158/0008-5472.22386351.v1