Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Richard D. Smrt"'
Autor:
Richard D. Smrt, Julialea Eaves-Egenes, Basam Z. Barkho, Nicholas J. Santistevan, Chunmei Zhao, James B. Aimone, Fred H. Gage, Xinyu Zhao
Publikováno v:
Neurobiology of Disease, Vol 27, Iss 1, Pp 77-89 (2007)
It is well known that Rett Syndrome, a severe postnatal childhood neurological disorder, is mostly caused by mutations in the MECP2 gene. However, how deficiencies in MeCP2 contribute to the neurological dysfunction of Rett Syndrome is not clear. We
Externí odkaz:
https://doaj.org/article/1be05c33e93e45438572ea91f30aa969
Autor:
Yuping Luo, Ge Shan, Weixiang Guo, Richard D Smrt, Eric B Johnson, Xuekun Li, Rebecca L Pfeiffer, Keith E Szulwach, Ranhui Duan, Basam Z Barkho, Wendi Li, Changmei Liu, Peng Jin, Xinyu Zhao
Publikováno v:
PLoS Genetics, Vol 6, Iss 4, p e1000898 (2010)
Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA-binding protein that can regulate the translation of specific mRNAs. Adult
Externí odkaz:
https://doaj.org/article/1d4519ea1c494336ae33dcd04417563b
Autor:
Hongda Li, Richard D. Smrt, Daniel P. Magyar, Eric D. Polich, Juan Su, Weixiang Guo, Xinyu Zhao, Yu Gao, Yina Xing, Qiang Chang
Publikováno v:
Stem Cells. 33:1618-1629
In both the embryonic and adult brain, a critical step in neurogenesis is neuronal maturation. Deficiency of MeCP2 leads to Rett syndrome, a severe neurodevelopmental disorder. We have previously shown that MeCP2 plays critical roles in the maturatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb5fd557a8edd92ccdd9078d43bfca2c
https://doi.org/10.1002/stem.1950
https://doi.org/10.1002/stem.1950
Publikováno v:
Human Molecular Genetics. 20:1834-1843
Functional deficiency of the X-linked methyl-CPG binding protein 2 (MeCP2) leads to the neurodevelopmental disorder Rett syndrome (RTT). Due to random X-chromosome inactivation (XCI), most RTT patients are females who are heterozygous for the MECP2 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b70f3baed6af8c5d7efafff8ecb3fe2
https://doi.org/10.1093/hmg/ddr066
https://doi.org/10.1093/hmg/ddr066
Autor:
Richard D. Smrt, Xinyu Zhao
Publikováno v:
Frontiers in Biology. 5:304-323
Dendrites and the dendritic spines of neurons play key roles in the connectivity of the brain and have been recognized as the locus of long-term synaptic plasticity, which is correlated with learning and memory. The development of dendrites and spine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dfa0df52b03241dbc09b76203f8277c
https://doi.org/10.1007/s11515-010-0650-0
https://doi.org/10.1007/s11515-010-0650-0
Autor:
Junmin Peng, Keith E. Szulwach, Richard D. Smrt, Rebecca L. Pfeiffer, Angélique Bordey, Xuekun Li, Yuping Luo, Manavendra Pathania, Xinyu Zhao, Weixiang Guo, Zhao-Qian Teng, Peng Jin
Publikováno v:
Stem Cells. 28:1060-1070
The maturation of young neurons is regulated by complex mechanisms and dysregulation of this process is frequently found in neurodevepmental disorders. MicroRNAs have been implicated in several steps of neuronal maturation including dendritic and axo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acc18242663cdddff538cf14a107ba82
https://doi.org/10.1002/stem.431
https://doi.org/10.1002/stem.431
Autor:
Yujing Li, Yuping Luo, Peng Jin, Keith E. Szulwach, Nicholas J. Santistevan, Wendi Li, Xuekun Li, Xinyu Zhao, Li Lin, Richard D. Smrt
Publikováno v:
The Journal of Cell Biology
The microRNA miR-137 represses expression of Ezh2, a histone methyltransferase, which in turn alters the epigenetic architecture of chromatin that is important for regulation of miR-137 levels.
Both microRNAs (miRNAs) and epigenetic regulation h
Both microRNAs (miRNAs) and epigenetic regulation h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6853806d24373a033160f3b643c4492b
https://doi.org/10.1083/jcb.200908151
https://doi.org/10.1083/jcb.200908151
Publikováno v:
Epigenetics. 2:126-134
Neural developmental disorders, such as autism, Rett Syndrome, Fragile X syndrome, and Angelman syndrome manifest during early postnatal neural development. Although the genes responsible for some of these disorders have been identified, how the muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa3b0d21dd324158f35d5dfdae16b19d
https://doi.org/10.4161/epi.2.2.4236
https://doi.org/10.4161/epi.2.2.4236
Autor:
Richard D. Smrt, Tomoko Kuwabara, Kinichi Nakashima, Basam Z. Barkho, Hongjun Song, Fred H. Gage, James B. Aimone, Xinyu Zhao
Publikováno v:
Stem Cells and Development. 15(3):407-421
Multipotent neural stem/progenitor cells (NSPCs) can be isolated from many regions of the adult central nervous system (CNS), yet neurogenesis is restricted to the hippocampus and subventricular zone in vivo. Identification of the molecular cues that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08345f4a0230350092f6ec81ab8e782
http://hdl.handle.net/10061/8562
http://hdl.handle.net/10061/8562
Autor:
Xuekun Li, Basam Z. Barkho, Yuping Luo, Keith E. Szulwach, Eric B. Johnson, Wendi Li, Xinyu Zhao, Weixiang Guo, Peng-Peng Jin, Chang-Mei Liu, Ge Shan, Richard D. Smrt, Ranhui Duan, Rebecca L. Pfeiffer
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 6, Iss 4, p e1000898 (2010)
PLoS Genetics, Vol 6, Iss 4, p e1000898 (2010)
Fragile X syndrome (FXS), the most common form of inherited mental retardation, is caused by the loss of functional fragile X mental retardation protein (FMRP). FMRP is an RNA–binding protein that can regulate the translation of specific mRNAs. Adu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b600b11f27579a886142e3f82534f64b
https://pubmed.ncbi.nlm.nih.gov/20386739
https://pubmed.ncbi.nlm.nih.gov/20386739