Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Richard D. Kolodner"'
Autor:
Felipe A. Calil, Bin-Zhong Li, Kendall A. Torres, Katarina Nguyen, Nikki Bowen, Christopher D. Putnam, Richard D. Kolodner
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Defects in DNA mismatch repair (MMR) have been linked to inherited and sporadic cancers. Here the authors demonstrate that the DNA repair protein Rad27 (human FEN1) functions in one of three redundant mispair excision pathways, where its flap endonuc
Externí odkaz:
https://doaj.org/article/edd8c42e20fe4ec2a4fcf1e024649b17
Autor:
Anna K. Miller, Guogen Mao, Breanna G. Knicely, Hannah G. Daniels, Christine Rahal, Christopher D. Putnam, Richard D. Kolodner, Eva M. Goellner
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
DNA mismatch repair (MMR) repairs replication errors, and MMR defects play a role in both inherited cancer predisposition syndromes and in sporadic cancers. MMR also recognizes mispairs caused by environmental and chemotherapeutic agents; however, in
Externí odkaz:
https://doaj.org/article/bfb164c88c9b4e268af71739856dca78
Autor:
Florian Hoss, James L. Mueller, Francisca Rojas Ringeling, Juan F. Rodriguez-Alcazar, Rebecca Brinkschulte, Gerald Seifert, Rainer Stahl, Lori Broderick, Chris D. Putnam, Richard D. Kolodner, Stefan Canzar, Matthias Geyer, Hal M. Hoffman, Eicke Latz
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Leucine-rich repeat (LRR) domains are commonly present in immune regulatory proteins. Here the authors show that LRR exonic modularity and alternative splicing of an LRR-containing protein, NLRP3, modulate the ratio of functional/afunctional NLRP3 is
Externí odkaz:
https://doaj.org/article/e8556fbf0c984427a366f6b71e4114ec
Autor:
Hannah L. Klein, Giedrė Bačinskaja, Jun Che, Anais Cheblal, Rajula Elango, Anastasiya Epshtein, Devon M. Fitzgerald, Belén Gómez-González, Sharik R. Khan, Sandeep Kumar, Bryan A. Leland, Léa Marie, Qian Mei, Judith Miné-Hattab, Alicja Piotrowska, Erica J. Polleys, Christopher D. Putnam, Elina A. Radchenko, Anissia Ait Saada, Cynthia J. Sakofsky, Eun Yong Shim, Mathew Stracy, Jun Xia, Zhenxin Yan, Yi Yin, Andrés Aguilera, Juan Lucas Argueso, Catherine H. Freudenreich, Susan M. Gasser, Dmitry A. Gordenin, James E. Haber, Grzegorz Ira, Sue Jinks-Robertson, Megan C. King, Richard D. Kolodner, Andrei Kuzminov, Sarah AE Lambert, Sang Eun Lee, Kyle M. Miller, Sergei M. Mirkin, Thomas D. Petes, Susan M. Rosenberg, Rodney Rothstein, Lorraine S. Symington, Pawel Zawadzki, Nayun Kim, Michael Lisby, Anna Malkova
Publikováno v:
Microbial Cell, Vol 6, Iss 1, Pp 1-64 (2019)
Understanding the plasticity of genomes has been greatly aided by assays for recombination, repair and mutagenesis. These assays have been developed in microbial systems that provide the advantages of genetic and molecular reporters that can readily
Externí odkaz:
https://doaj.org/article/9deb4e4edc524ec78e599b9f614eaef3
Autor:
Anjana Srivatsan, Bin-Zhong Li, Barnabas Szakal, Dana Branzei, Christopher D. Putnam, Richard D. Kolodner
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
SWR-C and its substrate the histone variant Htz1 are considered important for genome maintenance. Here the authors reveal that SWR-C/Htz1 plays a critical role during replication stress caused by absence of the replication fork progression proteins M
Externí odkaz:
https://doaj.org/article/26b3c91b973843c4a9d010d3be601fc1
Autor:
Christopher D. Putnam, Anjana Srivatsan, Rahul V. Nene, Sandra L. Martinez, Sarah P. Clotfelter, Sara N. Bell, Steven B. Somach, Jorge E.S. de Souza, André F. Fonseca, Sandro J. de Souza, Richard D. Kolodner
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Here, Richard Kolodner and colleagues use assays in Saccharomyces cerevisiaeto identify 182 genetic modifiers of gross chromosomal rearrangements (GCRs). They also compared these Genome Instability Suppressing (GIS) genes and pathways in human cancer
Externí odkaz:
https://doaj.org/article/f89534c401544c92a42a58da6b4da8ce
Publikováno v:
Cell Reports, Vol 4, Iss 1, Pp 174-188 (2013)
DNA damage activates checkpoint kinases that induce several downstream events, including widespread changes in transcription. However, the specific connections between the checkpoint kinases and downstream transcription factors (TFs) are not well und
Externí odkaz:
https://doaj.org/article/41d04e34ebda42168b3913bb56be7ccf
Autor:
Matthew L, DuPrie, Tatiana, Palacio, Felipe A, Calil, Richard D, Kolodner, Christopher D, Putnam
Eukaryotic DNA mismatch repair (MMR) initiates through mispair recognition by the MutS homologs Msh2-Msh6 and Msh2-Msh3 and subsequent recruitment of the MutL homologs Mlh1-Pms1 (human MLH1-PMS2). In bacteria, MutL is recruited by interactions with t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::166a87476c17ee868353eb6228023a4e
https://escholarship.org/uc/item/2z35f1f8
https://escholarship.org/uc/item/2z35f1f8
Autor:
Kendall A. Torres, Felipe A. Calil, Ann L. Zhou, Matthew L. DuPrie, Christopher D. Putnam, Richard D. Kolodner
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 42
Eukaryotic DNA mismatch repair (MMR) depends on recruitment of the Mlh1-Pms1 endonuclease (human MLH1-PMS2) to mispaired DNA. Both Mlh1 and Pms1 contain a long unstructured linker that connects the N- and carboxyl-terminal domains. Here, we demonstra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9a1a33b563d2db29613123ef305feec
https://escholarship.org/uc/item/84w9d1d7
https://escholarship.org/uc/item/84w9d1d7
Publikováno v:
SSRN Electronic Journal.
Genetic studies in Saccharomyces cerevisiae have identified 266 genes and predicted an additional 38 genes that suppress the accumulation of spontaneous gross chromosomal rearrangements (GCRs). Here we identified mutations that induce two DNA damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::378054ca165200f8596e5ce8aacac907
https://doi.org/10.2139/ssrn.4034883
https://doi.org/10.2139/ssrn.4034883