Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Richard D. Kennedy"'
Autor:
Anamarija Jurisic, Pei‐Ju Sung, Mark Wappett, Julien Daubriac, Ian T. Lobb, Wei‐Wei Kung, Nyree Crawford, Natalie Page, Eamon Cassidy, Stephanie Feutren‐Burton, J. S. Shane Rountree, Matthew D. Helm, Colin R. O'Dowd, Richard D. Kennedy, Gerald Gavory, Aaron N. Cranston, Daniel B. Longley, Xavier Jacq, Timothy Harrison
Publikováno v:
Clinical and Translational Medicine, Vol 14, Iss 4, Pp n/a-n/a (2024)
Abstract Background Understanding how to modulate the microenvironment of tumors that are resistant to immune checkpoint inhibitors represents a major challenge in oncology.Here we investigate the ability of USP7 inhibitors to reprogram the tumor mic
Externí odkaz:
https://doaj.org/article/c9655525645b43019fcffa228b383b32
Autor:
Jan Pencik, Cecile Philippe, Michaela Schlederer, Emine Atas, Matteo Pecoraro, Sandra Grund-Gröschke, Wen (Jess) Li, Amanda Tracz, Isabel Heidegger, Sabine Lagger, Karolína Trachtová, Monika Oberhuber, Ellen Heitzer, Osman Aksoy, Heidi A. Neubauer, Bettina Wingelhofer, Anna Orlova, Nadine Witzeneder, Thomas Dillinger, Elisa Redl, Georg Greiner, David D’Andrea, Johnny R. Östman, Simone Tangermann, Ivana Hermanova, Georg Schäfer, Felix Sternberg, Elena E. Pohl, Christina Sternberg, Adam Varady, Jaqueline Horvath, Dagmar Stoiber, Tim I. Malcolm, Suzanne D. Turner, Eileen E. Parkes, Brigitte Hantusch, Gerda Egger, Stefan Rose-John, Valeria Poli, Suneil Jain, Chris W. D. Armstrong, Gregor Hoermann, Vincent Goffin, Fritz Aberger, Richard Moriggl, Arkaitz Carracedo, Cathal McKinney, Richard D. Kennedy, Helmut Klocker, Michael R. Speicher, Dean G. Tang, Ali A. Moazzami, David M. Heery, Marcus Hacker, Lukas Kenner
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-25 (2023)
Abstract Prostate cancer (PCa) is a common and fatal type of cancer in men. Metastatic PCa (mPCa) is a major factor contributing to its lethality, although the mechanisms remain poorly understood. PTEN is one of the most frequently deleted genes in m
Externí odkaz:
https://doaj.org/article/55713eefba5d493d89c7d396451b3eb7
Autor:
Aya El Helali, Charlene H. L. Wong, Horace C. W. Choi, Wendy W. L. Chan, Naomi Dickson, Steven W. K. Siu, Karen K. Chan, Hextan Y. S. Ngan, Roger K. C. Ngan, Richard D. Kennedy
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract The efficacy of anti-angiogenic agents (AAAs) in epithelial ovarian cancer (EOC) remains unclear. Therefore, we conducted a systematic review and network meta-analysis (NMA) to synthesize evidence of their comparative effectiveness for impro
Externí odkaz:
https://doaj.org/article/62538a26db794afc8b0ffb64fb45f774
Autor:
Kieran G. Foley, Anita Lavery, Eoin Napier, David Campbell, Martin M. Eatock, Richard D. Kennedy, Kevin M. Bradley, Richard C. Turkington
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract 18F-fluorodeoxyglucose PET-CT may guide treatment decisions in patients with oesophageal adenocarcinoma (OAC). This study evaluated the added value of maximum standardised uptake value (SUVmax) to a novel DNA-damage immune response (DDIR) as
Externí odkaz:
https://doaj.org/article/335f4a45c8e3412591391e3d999c13de
Autor:
Eileen E. Parkes, Matthew P. Humphries, Elaine Gilmore, Fatima A. Sidi, Victoria Bingham, Su M. Phyu, Stephanie Craig, Catherine Graham, Joseph Miller, Daryl Griffin, Manuel Salto-Tellez, Stephen F. Madden, Richard D. Kennedy, Samuel F. Bakhoum, Stephen McQuaid, Niamh E. Buckley
Publikováno v:
npj Breast Cancer, Vol 7, Iss 1, Pp 1-11 (2021)
Abstract STING signaling in cancer is a crucial component of response to immunotherapy and other anti-cancer treatments. Currently, there is no robust method of measuring STING activation in cancer. Here, we describe an immunohistochemistry-based ass
Externí odkaz:
https://doaj.org/article/6790f073307d4fffbb5fb02a2f06cc1f
Autor:
Niamh H. McCabe, Leanne Stevenson, Enya Scanlon, Rosalie Douglas, Susanna Kennedy, Oliver Keminer, Björn Windshügel, Daniela Zisterer, Richard D. Kennedy, Jaine K. Blayney, Richard C. Turkington
Publikováno v:
Cancers, Vol 14, Iss 15, p 3726 (2022)
Drug resistance limits the effectiveness of oesophageal adenocarcinoma (OAC) chemotherapies, leading to a poor prognosis for this disease. Elucidation of the underlying resistance mechanisms is key to enabling the identification of more effective tre
Externí odkaz:
https://doaj.org/article/4e02f1d7736c4cf7a2810b4cd68bc148
Autor:
Conor Hanna, Victoria L. Dunne, Steven M. Walker, Karl T. Butterworth, Nuala McCabe, David J. J. Waugh, Richard D. Kennedy, Kevin M. Prise
Publikováno v:
Cancers, Vol 13, Iss 1, p 79 (2020)
Radical radiotherapy, often in combination with hormone ablation, is a safe and effective treatment option for localised or locally-advanced prostate cancer. However, up to 30% of patients with locally advanced PCa will go on to develop biochemical f
Externí odkaz:
https://doaj.org/article/a62f78dc9a0a4f0fb9772734e3854423
Autor:
Philip D. Dunne, Louise C. Brown, Timothy S. Maughan, Mark Lawler, Daniel B. Longley, Richard S. Kaplan, Letitia Campo, Viktor H. Koelzer, Ian Tomlinson, Patrick G. Johnston, Richard D. Kennedy, Manuel Salto-Tellez, Nicholas P. West, Philip Quirke, Dion G. Morton, Matthew T. Seymour, Ultan McDermott, Stephanie G. Craig, Matthew P. Humphries, Raheleh Amirkhah, Aikaterina Chatzipli, Gemma E. Logan, Steven M. Walker, Michael Youdell, Susan D. Richman, Keara L. Redmond, Sylvana Hassanieh, Andrew Blake, Enric Domingo, David J. Fisher, Sudhir B. Malla
Supplementary Results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9837817e7906381d03da436c4c0aba83
https://doi.org/10.1158/1078-0432.22479923
https://doi.org/10.1158/1078-0432.22479923
Autor:
Rosemary O'Connor, Alexander Marx, Suet-Feung Chin, Carlos Caldas, René Bernards, Richard D. Kennedy, William M. Gallagher, Ciara H. O'Flanagan, Nollaig Healy, Milan Bustamante-Garrido, Niamh E. Buckley, Bruce Moran, Bo Li, Katja Simon-Keller, Shelley J. Edmunds, Orla T. Cox
Related to Figure 6: Western blots and immunofluorescence images of PDLIM2 and b-catenin phospho-Ser675 expression and localization in BT549 cells overexpressing HA-PDLIM2 are included. Graph depicting measurements of cell migration in HA-PDLIM2-expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ca4bcb21dc6d2fea765d9b9a5239e49
https://doi.org/10.1158/0008-5472.22418270
https://doi.org/10.1158/0008-5472.22418270
Autor:
Philip D. Dunne, Louise C. Brown, Timothy S. Maughan, Mark Lawler, Daniel B. Longley, Richard S. Kaplan, Letitia Campo, Viktor H. Koelzer, Ian Tomlinson, Patrick G. Johnston, Richard D. Kennedy, Manuel Salto-Tellez, Nicholas P. West, Philip Quirke, Dion G. Morton, Matthew T. Seymour, Ultan McDermott, Stephanie G. Craig, Matthew P. Humphries, Raheleh Amirkhah, Aikaterina Chatzipli, Gemma E. Logan, Steven M. Walker, Michael Youdell, Susan D. Richman, Keara L. Redmond, Sylvana Hassanieh, Andrew Blake, Enric Domingo, David J. Fisher, Sudhir B. Malla
Figures S1-S9, Tables S1, S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::496cf180498237ddd1cd669c0717922a
https://doi.org/10.1158/1078-0432.22479920
https://doi.org/10.1158/1078-0432.22479920