Výsledky vyhledávání - "Richard D. Garman"

Nonclinical Evaluation of GMA161—An Antihuman CD16 (FcγRIII) Monoclonal Antibody for Treatment of Autoimmune Disorders in CD16 Transgenic Mice

Autor: Kathryn E. Stein, Nadine Tuaillon, Misty Troutt, Meghan M. Flaherty, Richard D. Garman, Laura Andrews, Tomas Magee, Ezio Bonvini, Timothy K. MacLachlan, Syd Johnson

Publikováno v: Toxicological Sciences. 125:299-309

Fc receptors are a critical component of the innate immune system responsible for the recognition of cross-linked antibodies and the subsequent clearance of pathogens. However, in autoimmune diseases, these receptors play a role in the deleterious ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2476a856b3eefc08cca6dc7707b9f5
https://doi.org/10.1093/toxsci/kfr278

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Murine Antithymocyte Globulin T-Cell Depletion Is Mediated Predominantly by Macrophages, but the Fas/FasL Pathway Selectively Targets Regulatory T Cells

Autor: Richard D. Garman, Melanie Ruzek, John M. Williams, Kathleen S. Neff, Susan M. Richards

Publikováno v: Transplantation. 92:523-528

Background Thymoglobulin is a T-cell-depleting polyclonal rabbit anti-human thymocyte antibody used clinically for immunosuppression in solid organ and hematopoietic stem-cell transplantation. By using a surrogate rabbit anti-mouse thymocyte globulin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d4afd363c157c15d78dd77b0a36e4cd
https://doi.org/10.1097/tp.0b013e31822923f7

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Immune tolerance induction to enzyme-replacement therapy by co-administration of short-term, low-dose methotrexate in a murine Pompe disease model

Autor: Richard D. Garman, Alexandra Joseph, Susan M. Richards, M Housman, K. Munroe

Publikováno v: Clinical and Experimental Immunology. 152:138-146

SummaryClinical investigations of recombinant human acid α-glucosidase for the treatment of Pompe disease often reveal the appearance of therapy-specific antibodies. These antibodies could potentially interfere with recombinant human acid α-glucosi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c907d4aa6bcbdc3b8a8ac7ffa9211eea
https://doi.org/10.1111/j.1365-2249.2008.03602.x

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Minimal Effects on Immune Parameters Following Chronic Anti-TGF-β Monoclonal Antibody Administration to Normal Mice

Autor: Richard D. Garman, John M. McPherson, Steve Ledbetter, Michael L. Hawes, Bruce Pratt, Melanie Ruzek, Susan M. Richards

Publikováno v: Immunopharmacology and Immunotoxicology. 25:235-257

Mice genetically deficient in TGF-beta1 or TGF-beta signaling capacity in T or B cells demonstrate profound immune dysregulation, as evidenced by increased lymph node size, expression of markers of memory/activation on T cells, inflammation in a vari

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4218ee7ff1fa82e6e21e482bb776d4f
https://doi.org/10.1081/iph-120020473

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Adenoviral Vectors Stimulate Murine Natural Killer Cell Responses and Demonstrate Antitumor Activities in the Absence of Transgene Expression

Autor: Richard D. Garman, Brian F. Kavanagh, Abraham Scaria, Susan M. Richards, Melanie Ruzek

Publikováno v: Molecular Therapy. 5(2):115-124

Adenoviral vector-mediated gene delivery is currently the focus of many efforts to administer therapeutic gene products for the treatment of cancer. Although these vectors are replication deficient, they can induce specific immune responses against b

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Transient low-dose methotrexate induces tolerance to murine anti-thymocyte globulin and together they promote long-term allograft survival

Autor: Julie Richard, Dinesh S. Bangari, Kathleen S. Neff, Marguerite Joly, Melanie Ruzek, Richard D. Garman, Alexandra Joseph, Kerry Culm-Merdek, Susan M. Richards, Lan Gao, John M. Williams

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 189(2)

Rabbit anti-thymocyte globulin (Thymoglobulin) effectively treats transplant rejection but induces anti-rabbit Ab responses, which limits routine readministration. Aiming to tolerize anti-rabbit responses, we coadministered a brief methotrexate regim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::512eadabcfdff40712b8105a49225912
https://pubmed.ncbi.nlm.nih.gov/22711884

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In vivo characterization of rabbit anti-mouse thymocyte globulin: a surrogate for rabbit anti-human thymocyte globulin

Autor: Michael A. Perricone, Kerry Culm-Merdek, Richard D. Garman, John M. Williams, Kathleen S. Neff, Karen A. Smith, Michael Luong, Melanie Ruzek, Susan M. Richards

Publikováno v: Transplantation. 88(2)

Background. Polyclonal rabbit anti-human thymocyte globulin (Thymoglobulin) is used clinically for immunosuppression in solid organ transplantation; however, it is difficult to fully characterize the effects of this agent in humans. Methods. A surrog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e7c8f5160116fb3976f7a2a9b3e55cf
https://pubmed.ncbi.nlm.nih.gov/19623011

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Homeostatic role of transforming growth factor-beta in the oral cavity and esophagus of mice and its expression by mast cells in these tissues

Autor: Carol A. Nelson, Robert Pawliuk, Douglas Matthews, Richard D. Garman, Melanie Ruzek, Arden Bond, Michael L. Hawes, Beth L. Thurberg, Scott Lonning, Allison Vitsky, James Waire, Emily R. LaCasse, Peter A. Piepenhagen, Steve Ledbetter, Laura Andrews, Susan M. Richards

Publikováno v: The American journal of pathology. 174(6)

Transforming growth factor-beta (TGF-beta) is a pleiotropic growth factor; its overexpression has been implicated in many diseases, making it a desirable target for therapeutic neutralization. In initial safety studies, mice were chronically treated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b49e4b2f3be65ac2295ffbce93bac52d
https://pubmed.ncbi.nlm.nih.gov/19406991

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Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo

Autor: Deborah A. Hopkins, Richard D. Garman, Srinivas Shankara, John M. Williams, James Waire, Bruce L. Roberts, Susan M. Richards, Gina Lacorcia, Jennifer Sullivan, Melanie Ruzek, John L. Dzuris, Sharon R. Nahill, Abraham Scaria

Publikováno v: Blood. 111(3)

Antithymocyte/antilymphocyte globulins are polyclonal antihuman T-cell antibodies used clinically to treat acute transplant rejection. These reagents deplete T cells, but a rabbit antihuman thymocyte globulin has also been shown to induce regulatory

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e32db65f02652ca76d5fe2409761a44
https://pubmed.ncbi.nlm.nih.gov/18025149

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Ultrasound imaging accurately detects skin thickening in a mouse scleroderma model

Autor: Jennifer Tedstone, Susan M. Richards, Melanie Ruzek, Richard D. Garman

Publikováno v: Ultrasound in medicinebiology. 34(8)

Systemic sclerosis (scleroderma) is characterized by initial thickening of the skin because of the accumulation of collagen within the dermis followed by progression of fibrosis to internal organs. Although ultrasound assessment of dermal thickening

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5b8443d41efe11c3adb50957ca031d7
https://pubmed.ncbi.nlm.nih.gov/18359143

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