Výsledky vyhledávání - "Richard D. Feinman"

Akademický článek

Ketone Bodies Induce Unique Inhibition of Tumor Cell Proliferation and Enhance the Efficacy of Anti-Cancer Agents

Autor: Anna I. Miller, David Diaz, Bo Lin, Patryk K. Krzesaj, Sarah Ustoyev, Alfred Shim, Eugene J. Fine, Ehsan Sarafraz-Yazdi, Matthew R. Pincus, Richard D. Feinman

Publikováno v: Biomedicines, Vol 11, Iss 9, p 2515 (2023)

The ketone bodies, sodium and lithium salts of acetoacetate (AcAc) and sodium 3-hydroxybutyrate (3-HB; commonly called beta-hydroxybutyrate) have been found to inhibit the proliferation of cancer cells. Previous studies have suggested that lithium it

Externí odkaz: https://doaj.org/article/b379fc706f9745df8ae1d84fe6abb45d

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Akademický článek

The effect of a ketogenic diet and synergy with rapamycin in a mouse model of breast cancer.

Autor: Yiyu Zou, Susan Fineberg, Alexander Pearlman, Richard D Feinman, Eugene J Fine

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0233662 (2020)

BackgroundThe effects of diet in cancer, in general, and breast cancer in particular, are not well understood. Insulin inhibition in ketogenic, high fat diets, modulate downstream signaling molecules and are postulated to have therapeutic benefits. O

Externí odkaz: https://doaj.org/article/7d4d44886e0648df925d46603a108c9d

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Inhibition of cancer cells in culture. The effects of treatment with ketone bodies and/or rapamycin treatment

Autor: Pincus Mr, Richard D. Feinman, Eugene J. Fine, Miller A, Lin B

BackgroundThe potential for ketogenic diets or administration of exogenous ketone bodies to treat or prevent to cancer remains encouraging. Of particular interest is the possibility that, whatever the effect of a nutritional intervention alone, the d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5fe8580c87f8785ff2392c921e92d0b5
https://doi.org/10.1101/2021.06.27.450024

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Re-evaluating low-carbohydrate diets and mortality

Autor: Richard D Feinman, Katharina Lechner, Eugene J Fine, Jennifer Elliott, Maeve Thompson-Starkey, L Amber O’Hearn, Nicolai Worm

Publikováno v: The Lancet. Public health

Summary Background Low carbohydrate diets, which restrict carbohydrate in favour of increased protein or fat intake, or both, are a popular weight-loss strategy. However, the long-term effect of carbohydrate restriction on mortality is controversial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce1b2722f7c5cd4a63ca5b349614bd6
https://doi.org/10.1016/s2468-2667(22)00118-9

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The biochemistry of low-carbohydrate and ketogenic diets

Autor: Richard D. Feinman

Publikováno v: Current opinion in endocrinology, diabetes, and obesity. 27(5)

Purpose of review To summarize the underlying biochemical basis for low-carbohydrate and ketogenic diets (LC/KD) and provide mechanisms to account for demonstrated effectiveness. Recent findings LC/KD continue to have success, to outperform other die

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d00199edeaa728b42c2ca7928a660116
https://pubmed.ncbi.nlm.nih.gov/32796164

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The Effect of a Ketogenic Diet and Synergy with Rapamycin in a Mouse Model of Breast Cancer

Autor: Susan Fineberg, Eugene J. Fine, Yiyu Zou, Alexander Pearlman, Richard D. Feinman

Publikováno v: PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0233662 (2020)

Background The effects of diet in cancer, in general, and breast cancer in particular, are not well understood. Insulin inhibition in ketogenic, high fat diets, modulate downstream signaling molecules and are postulated to have therapeutic benefits.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509217c8c01a4ec339f395b70049d861

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Acetoacetate Enhances the Cytotoxicity of Anti‐tumor Agents on MCF‐7 Breast Cancer Cells Without Itself Inducing Cell Death

Autor: Bo Lin, Anna Miller, Eugene J. Fine, Richard D. Feinman, Matthew J Pincus

Publikováno v: The FASEB Journal. 33

The potential for enhancing the effect of drugs, radiation or other modalities is one of the potential benefits of ketogenic diets for cancer therapy. Cancer cells grown in culture provide a model ...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::907fb5136b3312af19ce3ce06e6ccca1
https://doi.org/10.1096/fasebj.2019.33.1_supplement.lb231

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Insulin, carbohydrate restriction, metabolic syndrome and cancer

Autor: Richard D. Feinman, Eugene J. Fine

Publikováno v: Expert review of endocrinologymetabolism. 10(1)

We propose that dietary carbohydrate restriction, particularly ketogenic diets, may provide benefit as a therapeutic or preventive strategy in cancer, alone or as an adjunct to pharmacology. The argument derives from several points of evidence: There

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23aeec395d8c462e00f52612ee909316
https://pubmed.ncbi.nlm.nih.gov/30289045

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