Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Richard D. Bunker"'
Autor:
Dennis Gillingham, Jessica A. Gasser, Rob S. Sellar, Eric S. Fischer, Max Jan, Todd R. Golub, Manisha Manojkumar, Nicolas H. Thomä, Quinlan L. Sievers, Claudia Scholl, Stefan Fröhling, Li R. Wang, Zuzanna Kozicka, Katherine A. Donovan, Emma C. Fink, Adam S. Sperling, Yen-Der Li, Steven M. Corsello, Mikolaj Slabicki, Richard D. Bunker, Georg Petzold, Benjamin L. Ebert, Dakota Suchyta, Jonas Koeppel
Publikováno v:
Nature
Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin ligase, lead to protein degradation. Unlike traditional enzyme inhibitors, these molecular glue degraders act substoichiometrically to catalyse the rap
Autor:
Richard D. Bunker, Kerry M. Loomes, Amadeus Huang, Julia Burke, Edward N. Baker, Yee-Foong Mok, Michael D. W. Griffin
Publikováno v:
Biochemical Journal. 476:3369-3383
4-hydroxy-2-oxoglutarate aldolase (HOGA1) is a mitochondrial enzyme that plays a gatekeeper role in hydroxyproline metabolism. Its loss of function in humans causes primary hyperoxaluria type 3 (PH3), a rare condition characterised by excessive produ
Autor:
Andreas D. Schenk, Julius Rabl, Alessandro Potenza, Junpei Yamamoto, Dirk Schübeler, Ralph S. Grand, Shigenori Iwai, Simone Cavadini, Hitoshi Kurumizaka, Syota Matsumoto, Richard D. Bunker, Kaoru Sugasawa, Nicolas H. Thomä
Publikováno v:
Nature
Access to DNA packaged in nucleosomes is critical for gene regulation, DNA replication and DNA repair. In humans, the UV-damaged DNA-binding protein (UV-DDB) complex detects UV-light-induced pyrimidine dimers throughout the genome; however, it remain
Autor:
Nicolas H. Thomä, Lukas Burger, Richard D. Bunker, Georg Kempf, Zuzanna Kozicka, Syota Matsumoto, Dirk Schübeler, Luke Isbel, Ralph S. Grand, Andreas D. Schenk, Alicia K. Michael, Alexandra Graff-Meyer, Ganesh R. Pathare, Simone Cavadini, Joscha Weiss
Publikováno v:
Science
Engaging the nucleosome Cell identity is defined by gene expression patterns that are established through the binding of specific transcription factors. However, nucleosomal units limit access of transcription factors to specific DNA motifs within th
Autor:
Quinlan L. Sievers, Wassim Abdulrahman, Aline Renneville, Brian Liddicoat, Richard D. Bunker, Georg Petzold, Benjamin L. Ebert, Tarjei S. Mikkelsen, Nicolas H. Thomä
Publikováno v:
Molecular Cancer Therapeutics. 18:PL02-03
The small molecule drugs thalidomide, lenalidomide, and pomalidomide induce the ubiquitination and proteasomal degradation of Ikaros (IKZF1) and Aiolos (IKZF3) by mediating their interaction with Cereblon (CRBN), the substrate receptor of the CRL4CRB
Autor:
Quinlan L. Sievers, Georg Petzold, Richard D. Bunker, Aline Renneville, Mikołaj Słabicki, Brian Liddicoat, Wassim Abdulrahman, Tarjei Mikkelsen, Benjamin L. Ebert, Nicolas H. Thomä
The small molecule drugs thalidomide, lenalidomide, and pomalidomide induce ubiquitination and proteasomal degradation of the zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) by recruitment to Cereblon (CRBN), the substrate recepto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______2659::b8d7b26e8dfbc100c58910f9412d7050
https://zenodo.org/record/4412242
https://zenodo.org/record/4412242
Autor:
Brian J. Liddicoat, Nicolas H. Thomä, Mikolaj Slabicki, Tarjei S. Mikkelsen, Quinlan L. Sievers, Aline Renneville, Richard D. Bunker, Georg Petzold, Benjamin L. Ebert, Wassim Abdulrahman
Publikováno v:
Science
Thalidomide-targeted degradation Thalidomide and its analogs improve the survival of patients with multiple myeloma and other blood cancers. Previous work showed that the drugs bind to the E3 ubiquitin ligase Cereblon, which then targets for degradat
Autor:
Richard D. Bunker
The COP9 signalosome (CSN) is a large multi-protein complex in eukaryotes that is an essential regulator of intracellular protein degradation. Structures of human CSN were determined by X-ray crystallography from weakly diffracting crystals variably
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a8a65f22bafbf8c146825893a2dc323
https://doi.org/10.1039/9781788010504-00157
https://doi.org/10.1039/9781788010504-00157
Autor:
Elaine Chiu, Kimberly Rendek, Dingjie Wang, John C. H. Spence, Sébastien Boutet, R. Bruce Doak, Richard Bean, Cornelius Gati, Robert L. Shoeman, Dominik Oberthuer, Kenneth N. Goldie, Kenneth R. Beyerlein, Petra Fromme, Andrew Aquila, Karol Nass, Daniel P. DePonte, Raimund Fromme, Nadia A. Zatsepin, Peter Metcalf, Uwe Weierstall, Johannes A. Jehle, Shibom Basu, Anton Barty, Lukas Lomb, Garth J. Williams, Thomas A. White, Marc Messerschmidt, Daniel James, Henry N. Chapman, Oleksandr Yefanov, Ingo Grotjohann, Christopher Kupitz, Francesco Stellato, Shin Mei Yeh, Lorenzo Galli, Richard D. Bunker, Sabine Botha
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 114(9), 2247 – 2252 (2017). doi:10.1073/pnas.1609243114
Proceedings of the National Academy of Sciences of the United States of America 114(9), 2247 – 2252 (2017). doi:10.1073/pnas.1609243114
To understand how molecules function in biological systems, new methods are required to obtain atomic resol
To understand how molecules function in biological systems, new methods are required to obtain atomic resol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66f0d9e503944345be2626cc902eda1a
http://hdl.handle.net/2108/266644
http://hdl.handle.net/2108/266644
Autor:
Shigenori Iwai, Nicolas H. Thomä, Kaoru Sugasawa, Simone Cavadini, Dirk Schübeler, Julius Rabl, Hitoshi Kurumizaka, Junpei Yamamoto, Andreas D. Schenk, Richard D. Bunker, Alessandro Potenza, Ralph S. Grand, Syota Matsumoto
Publikováno v:
Nature. 571:E6-E6
In this Article, in Fig. 1a, the 5' and 3' labels were reversed in the DNA sequence, and Fig. 4 was missing panel labels a-e. These errors have been corrected online.