Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Richard D Horniblow"'
Publikováno v:
British Journal of Pharmacy, Vol 7, Iss 2 (2022)
Physiologically based pharmacokinetic (PBPK) modelling is a powerful alternative for paediatric clinical trials. Paediatric PBPK models require data on intestinal drug metabolising enzymes and transporter (DMET)-protein abundances, however only limit
Externí odkaz:
https://doaj.org/article/aa7152bf72cf4ee7891aadaa99a27b9c
Autor:
Nia Paddison Rees, Walaa Shaheen, Christopher Quince, Chris Tselepis, Richard D Horniblow, Naveen Sharma, Andrew D Beggs, Tariq H Iqbal, Mohammed Nabil Quraishi
Publikováno v:
EBioMedicine, Vol 81, Iss , Pp 104088- (2022)
Summary: Background: Faecal microbiota transplantation (FMT) has previously been explored as a treatment for ulcerative colitis (UC) however, biomarkers that predict and / or are associated with clinical response are poorly defined. The aim of this s
Externí odkaz:
https://doaj.org/article/09fb49a9c652447c98c3d60b21bf6f3e
Autor:
Richard D Horniblow, Miriam Dowle, Tariq H Iqbal, Gladys O Latunde-Dada, Richard E Palmer, Zoe Pikramenou, Chris Tselepis
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138240 (2015)
Alginates are a class of biopolymers with known iron binding properties which are routinely used in the fabrication of iron-oxide nanoparticles. In addition, alginates have been implicated in influencing human iron absorption. However, the synthesis
Externí odkaz:
https://doaj.org/article/c3c28604c7014766b89aa7a451867060
Publikováno v:
Food & Function. 14:3673-3685
Lignin chelates iron within the gastrointestinal lumen, altering bio-accessibility and leading to modulated enterocyte iron metabolism and changes in intestinal bacteria.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6631217e8fe3915519be94c278850aa
https://doi.org/10.1039/d2fo03807b
https://doi.org/10.1039/d2fo03807b
Autor:
Jan Goelen, Benoni Alexander, Haren Eranga Wijesinghe, Emily Evans, Gopal Pawar, Richard D. Horniblow, Hannah K. Batchelor
Publikováno v:
Pharmaceutics, Vol 13, Iss 10, p 1729 (2021)
Previous studies have used magnetic resonance imaging (MRI) to quantify the fluid in the stomach and small intestine of children, and the stomach, small intestine and colon of adults. This is the first study to quantify fluid volumes and distribution
Externí odkaz:
https://doaj.org/article/2ac288bd4d6a43ee9392c9fb8ae66a94
Autor:
Haren Eranga Wijesinghe, Benoni Alexander, Hannah Batchelor, Richard D. Horniblow, Jan Goelen, Emily Evans, Gopal Pawar
Publikováno v:
Pharmaceutics, Vol 13, Iss 1729, p 1729 (2021)
Pharmaceutics
Volume 13
Issue 10
Pharmaceutics
Volume 13
Issue 10
Previous studies have used magnetic resonance imaging (MRI) to quantify the fluid in the stomach and small intestine of children, and the stomach, small intestine and colon of adults. This is the first study to quantify fluid volumes and distribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ea0e5fdd2a717eee96d08d1710558d
https://www.mdpi.com/1999-4923/13/10/1729
https://www.mdpi.com/1999-4923/13/10/1729
Autor:
Richard D Horniblow, Prachi Pathak, Dario L Balacco, Animesh Acharjee, Eva Lles, Georgios Gkoutos, Andrew D Beggs, Chris Tselepis
Publikováno v:
The Journal of nutritional biochemistry. 101
The toxic effects of excess dietary iron within the colonic lumen are well documented, particularly in the context of Inflammatory Bowel Disease (IBD) and Colorectal Cancer (CRC). Proposed mechanisms that underpin iron-associated intestinal disease i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29e156f8eb2b378c8e1f5da1ca87cbce
https://pubmed.ncbi.nlm.nih.gov/34954079
https://pubmed.ncbi.nlm.nih.gov/34954079
Autor:
Gideon M. Hirschfield, Andrew D Beggs, Julian R.F. Walters, Tariq Iqbal, Richard D. Horniblow, Nicholas J. Loman, David R. Withers, Subrata Ghosh, Chris Tselepis, Georgios V. Gkoutos, Animesh Acharjee, Willem van Schaik, Mohammed Nabil Quraishi, Amanda E. Rossiter
Publikováno v:
Journal of Crohn's & Colitis
Background Although a majority of patients with PSC have colitis [PSC-IBD; primary sclerosing cholangitis-inflammatory bowel disease], this is phenotypically different from ulcerative colitis [UC]. We sought to define further the pathophysiological d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff14d2afd62d8247f4df41bde04072a3
https://pubmed.ncbi.nlm.nih.gov/32016358
https://pubmed.ncbi.nlm.nih.gov/32016358
Autor:
Robert Hollingworth, Matthew Bedford, Andrew D Beggs, Tariq Iqbal, Richard D. Horniblow, Chris Tselepis, Neeraj Lal, Emily Sutton, Sarah Evans
Publikováno v:
Cancer Science
A role for iron in carcinogenesis is supported by evidence that iron metabolism proteins are modulated in cancer progression. To date, however, the expression of iron regulatory protein‐2 (IRP2), which is known to regulate several iron metabolism p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e87bf987ffff5ec1c2dba38f8731ef
https://doi.org/10.1111/cas.13234
https://doi.org/10.1111/cas.13234
Autor:
Andrew D Beggs, Richard D. Horniblow, Pritesh Mistry, Tom Van de Wiele, Chris Tselepis, Tariq Iqbal, Mohammed Nabil Quraishi
Publikováno v:
Nutrients, Vol 11, Iss 3, p 674 (2019)
NUTRIENTS
Nutrients
NUTRIENTS
Nutrients
Evidence supporting the ferro-toxic nature of iron in the progression of inflammatory bowel disease (IBD) is becoming well established. A microbial dysbiosis is observed in IBD patients, and intra-luminal colonic-iron is able to support a more pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a01c1209dae5bc2e67ed1dc66a67051e
https://www.mdpi.com/2072-6643/11/3/674
https://www.mdpi.com/2072-6643/11/3/674