Výsledky vyhledávání - "Richard D Antrobus"

Akademický článek

A T cell-inducing influenza vaccine for the elderly: safety and immunogenicity of MVA-NP+M1 in adults aged over 50 years.

Autor: Richard D Antrobus, Patrick J Lillie, Tamara K Berthoud, Alexandra J Spencer, James E McLaren, Kristin Ladell, Teresa Lambe, Anita Milicic, David A Price, Adrian V S Hill, Sarah C Gilbert

Publikováno v: PLoS ONE, Vol 7, Iss 10, p e48322 (2012)

Current influenza vaccines have reduced immunogenicity and are of uncertain efficacy in older adults. We assessed the safety and immunogenicity of MVA-NP+M1, a viral-vectored influenza vaccine designed to boost memory T cell responses, in a group of

Externí odkaz: https://doaj.org/article/5ae393bd353248b788b0220b71fe0d22

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Virus-specific cytotoxic T lymphocytes differentially express cell-surface leukocyte immunoglobulin-like receptor-1, an inhibitory receptor for class I major histocompatibility complex molecules

Autor: Richard D Antrobus, Alan B. Rickinson, Paul Moss, Naeem Khan, Damien J. Montamat-Sicotte, Benjamin E. Willcox, Lee I. Garner, Andrew D. Hislop

Leukocyte immunoglobulin-like receptor-1 (LIR-1) is an inhibitory receptor that negatively regulates T cell effector functions after interaction with host class I major histocompatibility complex molecules and, additionally, binds to UL18, a human cy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6334941cd0093368993a1249020cb226
https://doi.org/10.1086/429927

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Clinical assessment of a novel recombinant simian adenovirus ChAdOx1 as a vectored vaccine expressing conserved Influenza A antigens

Autor: Richard D Antrobus, Tamara Berthoud, Teresa Lambe, Lynda Coughlan, Adrian V. S. Hill, Sarah C. Gilbert, Matthew D. J. Dicks

Publikováno v: Molecular Therapy

Adenoviruses are potent vectors for inducing and boosting cellular immunity to encoded recombinant antigens. However, the widespread seroprevalence of neutralizing antibodies to common human adenovirus serotypes limits their use. Simian adenoviruses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80fdcb40fca54df26545ff8349712f8
https://doi.org/10.1038/mt.2013.284

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T-Cell Responses in Children to Internal Influenza Antigens, 1 Year After Immunization With Pandemic H1N1 Influenza Vaccine, and Response to Revaccination With Seasonal Trivalent–inactivated Influenza Vaccine

Autor: Teresa Lambe, Simon Kerridge, Matthew D. Snape, Ly-Mee Yu, Hill Avs., Alexandra J. Spencer, Thompson Bav., Richard D Antrobus, Jeremy Chalk, C. Jones, Andrew J. Pollard, Caitlin E. Mullarkey, P de Whalley, Sarah C. Gilbert

Publikováno v: Pediatric Infectious Disease Journal. 31:e86-e91

Background: During seasonal influenza epidemics, 5-15% of the population are affected with an illness having a nontrivial mortality, morbidity and economic burden. Inactivated influenza vaccines are routinely used to prevent influenza infection, prim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bae669db57eb3a90c2be01cfa6fac0c
https://doi.org/10.1097/inf.0b013e318255e443

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A human vaccine strategy based on chimpanzee adenoviral and MVA vectors that primes, boosts, and sustains functional HCV-specific T cell memory

A protective vaccine against hepatitis C virus (HCV) remains an unmet clinical need. HCV infects millions of people worldwide and is a leading cause of liver cirrhosis and hepatocellular cancer. Animal challenge experiments, immunogenetics studies, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5630f96dad24f45d69729b6fdc5420ee
http://hdl.handle.net/11588/621565

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Coadministration of seasonal influenza vaccine and MVA-NP+M1 simultaneously achieves potent humoral and cell-mediated responses

Autor: Adrian V. S. Hill, Sarah C. Gilbert, Caitlin E. Mullarkey, Maria Zambon, Lynda Coughlan, Katja Hoschler, Richard D Antrobus, Tamara Berthoud

Publikováno v: Molecular Therapy. 22(1)

Current seasonal influenza vaccines have reduced immunogenicity and are of suboptimal efficacy in older adults. We have previously shown that the novel candidate vaccine MVA-NP+M1 is able to boost memory T cell responses in adults aged 50-85 years. P

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5df2acf24575933dfbcbb9d7a2853df9
http://ora.ox.ac.uk/objects/uuid:00071d4f-ec6e-43d2-85d7-e4c6a7427843

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Novel Adenovirus-based vaccines induce broad and sustained T cell responses to HCV in man

Currently, no vaccine exists for hepatitis C virus (HCV), a major pathogen thought to infect 170 million people globally. Many studies suggest that host T cell responses are critical for spontaneous resolution of disease, and preclinical studies have

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850fe882181402715e216e45f834e670
http://hdl.handle.net/11588/428786

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