Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Richard D, Wainford"'
Autor:
Anastasia Gkousioudi, Margherita Razzoli, Jesse D. Moreira, Richard D. Wainford, Yanhang Zhang
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract The prevalence of hypertension increases with aging and is associated with increased arterial stiffness. Resistant hypertension is presented when drug treatments fail to regulate a sustained increased blood pressure. Given that the mechanism
Externí odkaz:
https://doaj.org/article/604dd57b29c543e39171cc4005059567
Autor:
Sonali R. Gnanenthiran, Claudio Borghi, Dylan Burger, Bruno Caramelli, Fadi Charchar, Julio A. Chirinos, Jordana B. Cohen, Antoine Cremer, Gian Luca Di Tanna, Alexandre Duvignaud, Daniel Freilich, D. H. Frank Gommans, Abraham E. Gracia‐Ramos, Thomas A. Murray, Facundo Pelorosso, Neil R. Poulter, Michael A. Puskarich, Konstantinos D. Rizas, Rodolfo Rothlin, Markus P. Schlaich, Michael Schreinlecher, Ulrike Muscha Steckelings, Abhinav Sharma, George S. Stergiou, Christopher J. Tignanelli, Maciej Tomaszewski, Thomas Unger, Roland R. J. van Kimmenade, Richard D. Wainford, Bryan Williams, Anthony Rodgers, Aletta E. Schutte
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 17 (2022)
Background Published randomized controlled trials are underpowered for binary clinical end points to assess the safety and efficacy of renin‐angiotensin system inhibitors (RASi) in adults with COVID‐19. We therefore performed a meta‐analysis to
Externí odkaz:
https://doaj.org/article/1f10e3a056824f04b0479f27b6c3925f
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Hypertension, a major public health issue, is estimated to contribute to 10% of all deaths worldwide. Further, the salt sensitivity of blood pressure is a critical risk factor for the development of hypertension. The hypothalamic paraventricular nucl
Externí odkaz:
https://doaj.org/article/e5b672395e0a48088b973353e8dc2129
Autor:
Anastasia Gkousioudi, Xunjie Yu, Jacopo Ferruzzi, Juncheng Qian, Richard D. Wainford, Francesca Seta, Yanhang Zhang
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Metabolic syndrome increases the risk of cardiovascular diseases. Arteries gradually stiffen with aging; however, it can be worsened by the presence of conditions associated with metabolic syndrome. In this study, we investigated the combined effects
Externí odkaz:
https://doaj.org/article/3d20c3bf75a547348198cb0899ae39a8
Publikováno v:
Frontiers in Physiology, Vol 12 (2022)
The mechanisms that sense alterations in total body sodium content to facilitate sodium homeostasis in response to an acute sodium challenge that does not increase blood pressure have not been fully elucidated. We hypothesized that the renal sympathe
Externí odkaz:
https://doaj.org/article/5523167cd6444161bb615634cee3e566
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
We have previously reported that brain Gαi2 subunit proteins are required to maintain sodium homeostasis and are endogenously upregulated in the hypothalamic paraventricular nucleus (PVN) in response to increased dietary salt intake to maintain a sa
Externí odkaz:
https://doaj.org/article/4c02f0509f544d89a07ab29ca54daea1
Autor:
Anthony Rodgers, George Stergiou, Bryan Williams, Sonali Rukshana Gnanenthiran, Markus P Schlaich, Claudio Borghi, Dylan Burger, Fadi Charchar, Neil R Poulter, Ulrike Muscha Steckelings, Maciej Tomaszewski, Thomas Unger, Richard D Wainford, Aletta E Schutte
Publikováno v:
BMJ Open, Vol 11, Iss 2 (2021)
Introduction Whether ACE inhibitors (ACEi) or angiotensin II receptor blocker (ARB) therapy should be continued, initiated or ceased in patients with COVID-19 is uncertain. Given the widespread use of ACEi/ARBs worldwide, guidance on the use of these
Externí odkaz:
https://doaj.org/article/5ed6eafb09d144878bd26b19183d0b0d
Autor:
Aletta E Schutte, Tazeen H Jafar, Neil R Poulter, Albertino Damasceno, Nadia A Khan, Peter M Nilsson, Jafar Alsaid, Dinesh Neupane, Kazuomi Kario, Hind Beheiry, Sofie Brouwers, Dylan Burger, Fadi J Charchar, Myeong-Chan Cho, Tomasz J Guzik, Ghazi F Haji Al-Saedi, Muhammad Ishaq, Hiroshi Itoh, Erika S W Jones, Taskeen Khan, Yoshihiro Kokubo, Praew Kotruchin, Elizabeth Muxfeldt, Augustine Odili, Mansi Patil, Udaya Ralapanawa, Cesar A Romero, Markus P Schlaich, Abdulla Shehab, Ching Siew Mooi, U Muscha Steckelings, George Stergiou, Rhian M Touyz, Thomas Unger, Richard D Wainford, Ji-Guang Wang, Bryan Williams, Brandi M Wynne, Maciej Tomaszewski
Publikováno v:
Cardiovascular Research. 119:381-409
Abstract Raised blood pressure (BP) is the leading cause of preventable death in the world. Yet, its global prevalence is increasing, and it remains poorly detected, treated, and controlled in both high- and low-resource settings. From the perspectiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a3e1b6b62af2d9844db53c6a1b3464
https://doi.org/10.1093/cvr/cvac130
https://doi.org/10.1093/cvr/cvac130
Autor:
Alissa A. Frame, Richard D. Wainford
Publikováno v:
Kidney Research and Clinical Practice, Vol 36, Iss 2, Pp 117-131 (2017)
The pathophysiology of hypertension, which affects over 1 billion individuals worldwide, involves the integration of the actions of multiple organ systems, including the kidney. The kidney, which governs sodium excretion via several mechanisms includ
Externí odkaz:
https://doaj.org/article/3e14d24e16cb4cfa906f7c56fa77e694
Autor:
Kayla M Nist, Richard D Wainford
Publikováno v:
Hypertension. 79
Aim: We hypothesize paraventricular nucleus (PVN)-specific blood brain barrier (BBB) disruption and neuroinflammation increase hypertension and sympathoexcitation with age, promoting cognitive impairment, that can be attenuated by an Angiotensin II T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c0c10b002e5bafc299813d38fb45ed8
https://doi.org/10.1161/hyp.79.suppl_1.073
https://doi.org/10.1161/hyp.79.suppl_1.073