Zobrazeno 1 - 10
of 275
pro vyhledávání: '"Richard D, Minshall"'
Autor:
Elizabeth Le Master, Amit Paul, Dana Lazarko, Victor Aguilar, Sang Joon Ahn, James C. Lee, Richard D. Minshall, Irena Levitan
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract Endothelial stiffness is emerging as a major determinant in endothelial function. Here, we analyzed the role of caveolin-1 (Cav-1) in determining the stiffness of endothelial cells (EC) exposed to oxidized low density lipoprotein (oxLDL) und
Externí odkaz:
https://doaj.org/article/640163550fc64db9adb8baf2322bddc2
Autor:
Zhenlong Chen, Richard D. Minshall
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/1e201a2cf7714104b3dc54d25aa01824
Autor:
Imaduddin Mirza, Mohamed Haloul, Chandra Hassan, Mario Masrur, Amro Mostafa, Francesco M. Bianco, Mohamed M. Ali, Richard D. Minshall, Abeer M. Mahmoud
Publikováno v:
Cells, Vol 12, Iss 20, p 2453 (2023)
Glycosphingolipids (GSLs) are products of lipid glycosylation that have been implicated in the development of cardiovascular diseases. In diabetes, the adipocyte microenvironment is characterized by hyperglycemia and inflammation, resulting in high l
Externí odkaz:
https://doaj.org/article/2c5d1cd43e39495a90a0ca28a5ca3562
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Introduction: Chronic, non-healing skin wounds such as diabetic foot ulcers (DFUs) are common in patients with type 2 diabetes mellitus (T2DM) and often result in limb amputation and even death. However, mechanisms by which T2DM and inflammation nega
Externí odkaz:
https://doaj.org/article/4593eac5b8344f379f94b72e6979d82a
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
Rationale and Goal: Endothelial cells (ECs) are quiescent and critical for maintaining homeostatic functions of the mature vascular system, while disruption of quiescence is at the heart of endothelial to mesenchymal transition (EndMT) and tumor angi
Externí odkaz:
https://doaj.org/article/70983a8732bf49e1b9d34475b17752b1
Autor:
Ejehi O. Erewele, Maricela Castellon, Omar Loya, Glenn Marshboom, Andrew Schwartz, Kayla Yerlioglu, Christopher Callahan, Jiwang Chen, Richard D. Minshall, Suellen D. Oliveira
Publikováno v:
Pulmonary Circulation, Vol 12, Iss 4, Pp n/a-n/a (2022)
Abstract Dysfunctional bone morphogenetic protein receptor 2 (BMPR2) and endothelial nitric oxide synthase (eNOS) have been largely implicated in the pathogenesis of pulmonary arterial hypertension (PAH); a life‐threatening cardiopulmonary disease.
Externí odkaz:
https://doaj.org/article/c8fbd96c90b94397b115aaf28a3ae997
Autor:
Ying Jiang, Sarah Krantz, Xiang Qin, Shun Li, Hirushi Gunasekara, Young-Mee Kim, Adriana Zimnicka, Misuk Bae, Ke Ma, Peter T. Toth, Ying Hu, Ayesha N. Shajahan-Haq, Hemal H. Patel, Saverio Gentile, Marcelo G. Bonini, Jalees Rehman, Yiyao Liu, Richard D. Minshall
Publikováno v:
Redox Biology, Vol 52, Iss , Pp 102304- (2022)
As essential regulators of mitochondrial quality control, mitochondrial dynamics and mitophagy play key roles in maintenance of metabolic health and cellular homeostasis. Here we show that knockdown of the membrane-inserted scaffolding and structural
Externí odkaz:
https://doaj.org/article/5ff54eba886243c59a38ab64bfa4363d
Autor:
Joshua H. Jones, Richard D. Minshall
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Acute Lung Injury (ALI) is characterized by widespread inflammation which in its severe form, Acute Respiratory Distress Syndrome (ARDS), leads to compromise in respiration causing hypoxemia and death in a substantial number of affected individuals.
Externí odkaz:
https://doaj.org/article/c36dacf82e48424ca80a73d5274be188
Autor:
Vitalyi Senyuk, Najmeh Eskandari, Ying Jiang, Rebeca Garcia-Varela, Rachel Sundstrom, Luigi Leanza, Roberta Peruzzo, Mark Burkard, Richard D. Minshall, Saverio Gentile
Publikováno v:
Redox Biology, Vol 45, Iss , Pp 102030- (2021)
Potassium channels are important regulators of cellular homeostasis and targeting these proteins pharmacologically is unveiling important mechanisms in cancer cell biology. Here we demonstrate that pharmacological stimulation of the Kv11.1 potassium
Externí odkaz:
https://doaj.org/article/09ec8a0b65244902861e4b4ce6051d36
Autor:
Zdravka Daneva, Matteo Ottolini, Yen Lin Chen, Eliska Klimentova, Maniselvan Kuppusamy, Soham A Shah, Richard D Minshall, Cheikh I Seye, Victor E Laubach, Brant E Isakson, Swapnil K Sonkusare
Publikováno v:
eLife, Vol 10 (2021)
Pannexin 1 (Panx1), an ATP-efflux pathway, has been linked with inflammation in pulmonary capillaries. However, the physiological roles of endothelial Panx1 in the pulmonary vasculature are unknown. Endothelial transient receptor potential vanilloid
Externí odkaz:
https://doaj.org/article/4e52c48d21c241c0a4496dbc4db01f8d