Výsledky vyhledávání - "Richard Cubberley"

Use of human liver and EpiSkin™ S9 subcellular fractions as a screening assays to compare the in vitro hepatic and dermal metabolism of 47 cosmetics‐relevant chemicals

Autor: Eric Arbey, Richard Cubberley, Joan Eilstein, Martina Klaric, Hélène Duplan, Carine Jacques-Jamin, Nicola J. Hewitt, Corie A. Ellison, Camille Genies, Helga Rothe, Daniela Lange, Aurélie Fabre, Sébastien Grégoire, Andreas Schepky

Publikováno v: Journal of Applied Toxicology. 40:416-433

The abundance of xenobiotic metabolizing enzymes (XMEs) is different in the skin and liver; therefore, it is important to differentiate between liver and skin metabolism when applying the information to safety assessment of topically applied ingredie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a426ce4e883d06c3f8e4603b7b0c4be3
https://doi.org/10.1002/jat.3914

Zobrazit plný text záznamu

PBK modelling of topical application and characterisation of the uncertainty of C

Autor: Hequn, Li, Joe, Reynolds, Ian, Sorrell, David, Sheffield, Ruth, Pendlington, Richard, Cubberley, Beate, Nicol

Publikováno v: Toxicology and applied pharmacology. 442

Combined with in vitro bioactivity data, physiologically based kinetic (PBK) models has increasing applications in next generation risk assessment for animal-free safety decision making. A tiered framework of building PBK models for such application

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2b32f06a7079d2121ccdd62866c66913
https://pubmed.ncbi.nlm.nih.gov/35346730

Zobrazit plný text záznamu

Comparison of the metabolism of 10 cosmetics‐relevant chemicals in EpiSkin™ S9 subcellular fractions and in vitro human skin explants

Autor: Aurélie Fabre, Richard Cubberley, Carine Jacques-Jamin, Helga Rothe, Martina Klaric, Sébastien Grégoire, Eric Arbey, Daniela Lange, Hélène Duplan, Nicola J. Hewitt, Joan Eilstein, Andreas Schepky, Corie A. Ellison, Camille Genies

Publikováno v: Journal of Applied Toxicology. 40:313-326

An understanding of the bioavailability of topically applied cosmetics ingredients is key to predicting their local skin and systemic toxicity and making a safety assessment. We investigated whether short-term incubations with S9 from the reconstruct

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d486eddc1be6ffa25ec5f8fa5d21e98
https://doi.org/10.1002/jat.3905

Zobrazit plný text záznamu

Use of a Simple in vitro Test to Assess Loss of Chemical due to Volatility during an in vitro Human Skin Absorption Study

Autor: Joan Eilstein, Sébastien Grégoire, Camille Genies, Andreas Schepky, Richard Cubberley, Carine Jacques-Jamin, Hélène Duplan, Nicola J. Hewitt, Helga Rothe, Corie A. Ellison, Martina Klaric, Julien Fernandez

Publikováno v: Skin Pharmacology and Physiology. 32:117-124

Background: We tested the cutaneous distribution of 50 chemicals in frozen human skin. The mass balance (MB) values for 48% of the chemicals were < 90%, possibly due to evaporation. Methods: We confirmed the reduction in MB was due to evaporation for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe6a0716b00535fd2c8e799dd13bce50
https://doi.org/10.1159/000497105

Zobrazit plný text záznamu

A Next-Generation Risk Assessment Case Study for Coumarin in Cosmetic Products

Publikováno v: Toxicological Sciences

Next-Generation Risk Assessment is defined as an exposure-led, hypothesis-driven risk assessment approach that integrates new approach methodologies (NAMs) to assure safety without the use of animal testing. These principles were applied to a hypothe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79cca35e755eaacc289b91b57115058f
https://pubmed.ncbi.nlm.nih.gov/32275751

Zobrazit plný text záznamu

A hypothetical skin sensitisation next generation risk assessment for coumarin in cosmetic products

Autor: Joe Reynolds, Richard Cubberley, G. Reynolds, Nicola Gilmour, Maria Teresa Baltazar, K. Przybylak, A. Aptula, S. Spriggs, Gavin Maxwell, S. Windebank

Publikováno v: Regulatory Toxicology and Pharmacology. 127:105075

Next generation Risk Assessment (NGRA) is an exposure-led, hypothesis-driven approach which integrates new approach methodologies (NAMs) to assure safety without generating animal data. This hypothetical skin allergy risk assessment of two consumer p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6acced286173ad31321938e964e0dc88
https://doi.org/10.1016/j.yrtph.2021.105075

Zobrazit plný text záznamu

Comparison of protocols measuring diffusion and partition coefficients in the stratum corneum

Autor: Andreas Schepky, Nicola J. Hewitt, C. Avci, Richard Cubberley, Carine Jacques-Jamin, Cindy Obringer, Martina Klaric, John Manwaring, Hélène Duplan, Sébastien Grégoire, Helga Rothe, Daniela Lange, William Wargniez, Joan Eilstein

Publikováno v: Journal of Applied Toxicology. 37:806-816

Partition (K) and diffusion (D) coefficients are important to measure for the modelling of skin penetration of chemicals through the stratum corneum (SC). We compared the feasibility of three protocols for the testing of 50 chemicals in our main stud

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6ca9bf3c400930621640203506c9db21
https://doi.org/10.1002/jat.3427

Zobrazit plný text záznamu

Comparison of the Skin Penetration of 3 Metabolically Stable Chemicals Using Fresh and Frozen Human Skin

Autor: Richard Cubberley, Carine Jacques-Jamin, Daniela Lange, Joan Eilstein, Martina Klaric, Helga Rothe, Sébastien Grégoire, Andreas Schepky, Ophelie Vaillant, H. Duplan, Nicola J. Hewitt, Corie A. Ellison

Publikováno v: Skin Pharmacology and Physiology. 30:234-245

Background: The Cosmetics Europe ADME Task Force is developing in vitro and in silico tools for predicting skin and systemic concentrations after topical application of cosmetic ingredients. There are conflicting reports as to whether the freezing pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df6e4d951b4bc1da1882680279400a03
https://doi.org/10.1159/000475472

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání