Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Richard Crux"'
Autor:
Anderley Gordon, Benjamin Challoner, Avani Athauda, Andrew Woolston, Sonia Mansukhani, Matt Dunstan, Nikoletta Petrou, Komel Khabra, Retchel Lazaro-Alcausi, Richard Crux, Victoria Borja, Ruwaida Begum, Isma Rana, Sheela Rao, Sacheen Kumar, David Cunningham, Ian Chau, Naureen Starling, M. Asif Chaudry, Marco Gerlinger
Publikováno v:
Journal of Clinical Oncology. 41:446-446
446 Background: ICONIC evaluated 4+4 cycles of FLOT-A (2-weekly standard FLOT with 10mg/kg of the anti-PDL1 antibody avelumab) for perioperative treatment of early-stage OGA. We report R0 resection rates, pathologic complete response rates (pCR), pat
Autor:
Benjamin R. Challoner, Andrew Woolston, David Lau, Marta Buzzetti, Caroline Fong, Louise J. Barber, Gayathri Anandappa, Richard Crux, Ioannis Assiotis, Kerry Fenwick, Ruwaida Begum, Dipa Begum, Tom Lund, Nanna Sivamanoharan, Harold B. Sansano, Melissa Domingo-Arada, Amina Tran, Bryony Eccles, Richard Ellis, Stephen Falk, Mark Hill, Daniel Krell, Nirupa Murugaesu, Luke Nolan, Vanessa Potter, Mark Saunders, Kai-Keen Shiu, Sebastian Guettler, James L. Alexander, Héctor Lázare-Iglesias, James Kinross, Jamie Murphy, Katharina von Loga, David Cunningham, Ian Chau, Naureen Starling, Juan Ruiz-Bañobre, Tony Dhillon, Marco Gerlinger
Mismatch repair deficient colorectal cancers have high mutation loads and many respond to immune checkpoint-inhibitors. We investigated how genetic and immune landscapes co-evolve in these tumors. All cases had high truncal mutation loads. Driver abe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b0034cbd8dbfa0674f6a03528d18c73
https://doi.org/10.1101/2022.02.16.479224
https://doi.org/10.1101/2022.02.16.479224
Autor:
Benjamin R. Challoner, Andrew Woolston, David Lau, Marta Buzzetti, Louise J. Barber, Tom Lund, Harold B. Sansano, Katharina von Loga, Héctor Lázare-Iglesias, Ruwaida Begum, Richard Crux, David Cunningham, Ian Chau, Naureen Starling, Juan Ruiz-Bañobre, Tony Dhillon, Marco Gerlinger
Publikováno v:
Cancer Research. 82:A002-A002
This abstract is being presented as a short talk in the scientific program. A full abstract is available in the Proffered Abstracts section (PR012) of the Conference Proceedings. Citation Format: Benjamin R. Challoner, Andrew Woolston, David Lau, Mar
Autor:
Benjamin R. Challoner, Andrew Woolston, David Lau, Marta Buzzetti, Louise J. Barber, Tom Lund, Harold B. Sansano, Katharina von Loga, Héctor Lázare-Iglesias, Ruwaida Begum, Richard Crux, David Cunningham, Ian Chau, Naureen Starling, Juan Ruiz-Bañobre, Tony Dhillon, Marco Gerlinger
Publikováno v:
Cancer Research. 82:PR012-PR012
Mismatch repair deficient (MMRd) CRCs have high mutation/neo-antigen loads, leading to high immunogenicity and good immunotherapy response rates. We reasoned that the MMRd hypermutator phenotype should also promote intratumor heterogeneity (ITH) and
Autor:
David Cunningham, Ian Tomlinson, Angela Gillbanks, Ian Chau, Eleftheria Kalaitzaki, Naureen Starling, Sarah Wordsworth, Nicola E. Annels, David K. Lau, Marco Gerlinger, Ruwaida Begum, G. Smith, Hardev Pandha, David N. Church, Richard Crux, Francesco Sclafani, Tony Dhillon
Publikováno v:
Lau, D, Kalaitzaki, E, Church, D N, Pandha, H, Tomlinson, I, Annels, N, Gerlinger, M, Sclafani, F, Smith, G, Begum, R, Crux, R, Gillbanks, A, Wordsworth, S, Chau, I, Starling, N, Cunningham, D & Dhillon, T 2020, ' Rationale and design of the POLEM trial: avelumab plus fluoropyrimidine-based chemotherapy as adjuvant treatment for stage III mismatch repair deficient or POLE exonuclease domain mutant colon cancer : a phase III randomised study ', ESMO Open, vol. 5, no. 1, e000638 . https://doi.org/10.1136/esmoopen-2019-000638
ESMO Open
ESMO Open
Background 10%–15% of early-stage colon cancers harbour either deficient mismatch repair (dMMR), microsatellite instability high (MSI-H) or POLE exonuclease domain mutations, and are characterised by high tumour mutational burden and increased lymp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88c44ad904fa83f88fdd194786b9e2e7
https://hdl.handle.net/20.500.11820/bf7a85ea-5de1-4543-af79-722f0f9d79e6
https://hdl.handle.net/20.500.11820/bf7a85ea-5de1-4543-af79-722f0f9d79e6
Autor:
Naureen Starling, Richard Crux, Hardev Pandha, Ian Tomlinson, Marco Gerlinger, Eleftheria Kalaitzaki, David K. Lau, David Cunningham, Rachel Powell, David N. Church, Ian Chau, Francesco Sclafani, Tony Dhillon, Nicola E. Annels, Angela Gillbanks
Publikováno v:
Journal of Clinical Oncology. 37:TPS3615-TPS3615
TPS3615 Background: Colon cancer with deficient mismatch repair (dMMR) and POLE mutations are characterised by a high tumor mutational burden (TMB) and an immunogenic lymphocyte infiltrate. Approximately 12% of stage III colon cancer have dMMR. POLE
Autor:
Thomas Tomkos, Richard Crux
Publikováno v:
Innovatives Beschaffungsmanagement ISBN: 9783834928450
Die CPO-Funktion hat eine enorme Phase der Emanzipation durchlebt. Dennoch: Kaum eine Funktion verfugt uber so unterschiedliche Auspragungen in ihrer Definition wie die des Einkaufs. Dies gilt sogar fur Unternehmen der gleichen Branche. Wahrend Finan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b324e998ed8903b82da6dd2bec29f726
https://doi.org/10.1007/978-3-8349-6748-0_5
https://doi.org/10.1007/978-3-8349-6748-0_5
Autor:
Andreas Scherfke, Richard Crux
Publikováno v:
Das Handbuch Direct Marketing & More ISBN: 9783322902214
Der Beitrag beschreibt die Entwicklung vom transaktionsorientierten zum relationalen Marketing. Ausloser sind Marktumbruche und technologische Innovationssprunge. Dies hat tiefgreifende Auswirkungen auf die gesamten Unternehmensstrukturen. In den Bli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f98aae2e730467cb5722f23ebc2f76e6
https://doi.org/10.1007/978-3-322-90220-7_63
https://doi.org/10.1007/978-3-322-90220-7_63
Autor:
Richard Crux
Publikováno v:
Crossmedia-Strategien ISBN: 9783322823564
Ein neues Modewort und damit ein neuer Trend scheint sich in der Kommunikationsbranche zu etablieren — „Crossmedia-Marketing“.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de5c6f373d6eab67175feb6d24d9b27b
https://doi.org/10.1007/978-3-322-82355-7_3
https://doi.org/10.1007/978-3-322-82355-7_3