Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Richard Charboneau"'
Autor:
Steven M. Santilli, Alice Chanakira, Roderick A. Barke, Sabita Roy, Richard Charboneau, Raini Dutta
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 302:H1173-H1184
Despite intensive research studies, theories have yet to focus on the contribution of hypoxia to patency differences observed clinically between arterial vs. venous grafts. This study investigates the differential hypoxic response of smooth muscle ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d5a99b6c46810a06733e5ca6cc391da
https://doi.org/10.1152/ajpheart.00411.2011
https://doi.org/10.1152/ajpheart.00411.2011
Publikováno v:
Archivum Immunologiae et Therapiae Experimentalis. 56:299-309
The first line of defense against invading bacteria is provided by the innate immune system. Morphine and other opiates can immediately disrupt the body's first line of defense against harmful external bacteria. Opiate, for example morphine, abuse de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ae0f1d0ad4432c19e358b957e78276
https://doi.org/10.1007/s00005-008-0035-0
https://doi.org/10.1007/s00005-008-0035-0
Autor:
Jinghua Wang, Jana Ninkovic, Roderick A. Barke, Richard Charboneau, Sabita Roy, Anitha Krishnan, Jennifer Kelschenbach
Publikováno v:
The Journal of Immunology. 180:3670-3679
There are very few studies that examine the effects that morphine withdrawal has on immune functioning, and of these even fewer describe the mechanisms by which withdrawal brings about these changes. Our previous work demonstrated that morphine withd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc24679ba53e454973c958cc5f01820
https://doi.org/10.4049/jimmunol.180.6.3670
https://doi.org/10.4049/jimmunol.180.6.3670
Autor:
Jana Ninkovic, Jing Ma, Umakant Sharma, Santanu Banerjee, Jingjing Meng, Richard Charboneau, Sabita Roy
Publikováno v:
Scientific Reports
Opportunistic lung infection and inflammation is a hallmark of chronic recreational/clinical use of morphine. We show that early induction of IL17 from the bronchial epithelium, following pathogenic encounter is a protective response, which contribut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa510fc5386145bbfd45547a3285016
https://doi.org/10.1038/srep11384
https://doi.org/10.1038/srep11384
Publikováno v:
The Journal of Immunology. 175:6361-6367
Impaired host defense mechanisms after major operative procedures and trauma are recognized as important factors in the development of infectious complication. Trauma is associated with impaired cellular immunity and CD4+ T cell Th2 differentiation.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb147b6abaf5ef5882073ae4efd5bba9
https://doi.org/10.4049/jimmunol.175.10.6361
https://doi.org/10.4049/jimmunol.175.10.6361
Publikováno v:
The Journal of Immunology. 174:426-434
Chronic morphine use impairs host innate immune response and increases susceptibility to bacteria and virus. In this study a novel mouse model of chronic morphine treatment, followed by intranasal inoculation with Streptococcus pneumoniae, was used t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d271828d75b3543642a59578397fca1a
https://doi.org/10.4049/jimmunol.174.1.426
https://doi.org/10.4049/jimmunol.174.1.426
Autor:
Sumandeep Gupta, Richard Charboneau, Roderick A. Barke, Jinghua Wang, Sabita Roy, Horace H. Loh
Publikováno v:
Journal of Neuroimmunology. 147:78-81
Chronic morphine treatment in animal models has been shown to alter a number of immune parameters including suppression of cellular immunity. T helper cell differentiation into Th2 effector cell may be a major contributing factor to impaired cellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c2ad78f61a07aa323cde6e480eafae3
https://doi.org/10.1016/j.jneuroim.2003.10.016
https://doi.org/10.1016/j.jneuroim.2003.10.016
Publikováno v:
Journal of Biological Chemistry. 278:37622-37631
To explore the mechanism by which morphine promotes the incidence of HIV infection, we evaluated the regulatory role of morphine on the interferon-gamma (IFN-gamma) promoter in activated T cells from wild type and mu-opioid receptor knockout mice. Ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f377f3ca973635f98de96bc2590b0f91
https://doi.org/10.1074/jbc.m301224200
https://doi.org/10.1074/jbc.m301224200
Autor:
Roderick A. Barke, Richard Charboneau, Jinghua Wang, Horace H. Loh, Sudha Balasubramanian, Sabita Roy
Publikováno v:
Journal of Leukocyte Biology. 71:782-790
Wild-type and-opioid receptor knock- out (MORKO) mice were used to investigate the role of corticosterone (CORT) and the -opioid receptor (MOR) in chronic morphine-mediated im- munosuppression. We found that although plasma CORT concentrations in COR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec7bafacec5803110d5f1129439f1688
https://doi.org/10.1189/jlb.71.5.782
https://doi.org/10.1189/jlb.71.5.782
Publikováno v:
Surgery. 128:219-224
Background: Interleukin-4 (IL-4) treatment after lipopolysaccharide (LPS) induction inhibits macrophage (Mφ) IL-12 synthesis; however, IL-4 pretreatment (PreTx) primes the Mφ for increased LPS-induced IL-12 production. In this study we study the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6572bec9c0d2dcc2d02e7f2d41dea826
https://doi.org/10.1067/msy.2000.108063
https://doi.org/10.1067/msy.2000.108063