The LEAP2 Response to Cancer-Related Anorexia-Cachexia Syndrome in Male Mice and Patients.

Autor: Varshney S; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Shankar K; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Kerr HL; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.; Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA 98195, USA., Anderson LJ; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.; Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA 98195, USA., Gupta D; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Metzger NP; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Singh O; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Ogden SB; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Paul S; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Piñon F; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Osborne-Lawrence S; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Richard CP; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Lawrence C; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Mani BK; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Garcia JM; Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98108, USA.; Gerontology and Geriatric Medicine, Department of Medicine, University of Washington, Seattle, WA 98195, USA., Zigman JM; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Division of Endocrinology & Metabolism, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA.

Publikováno v: Endocrinology [Endocrinology] 2024 Sep 26; Vol. 165 (11).

Ghrelin deletion and conditional ghrelin cell ablation increase pancreatic islet size in mice.

Autor: Gupta D, Burstein AW, Schwalbe DC, Shankar K, Varshney S, Singh O, Paul S, Ogden SB, Osborne-Lawrence S, Metzger NP, Richard CP, Campbell JN, Zigman JM

Publikováno v: The Journal of clinical investigation [J Clin Invest] 2024 May 15; Vol. 134 (10). Date of Electronic Publication: 2024 May 15.

Ghrelin-responsive mediobasal hypothalamic neurons mediate exercise-associated food intake and exercise endurance.

Autor: Singh O; Center for Hypothalamic Research, Department of Internal Medicine., Ogden SB; Center for Hypothalamic Research, Department of Internal Medicine., Varshney S; Center for Hypothalamic Research, Department of Internal Medicine., Shankar K; Center for Hypothalamic Research, Department of Internal Medicine., Gupta D; Center for Hypothalamic Research, Department of Internal Medicine., Paul S; Center for Hypothalamic Research, Department of Internal Medicine., Osborne-Lawrence S; Center for Hypothalamic Research, Department of Internal Medicine., Richard CP; Center for Hypothalamic Research, Department of Internal Medicine., Metzger NP; Center for Hypothalamic Research, Department of Internal Medicine., Lawrence C; Center for Hypothalamic Research, Department of Internal Medicine., Leon Mercado L; Center for Hypothalamic Research, Department of Internal Medicine., Zigman JM; Center for Hypothalamic Research, Department of Internal Medicine.; Division of Endocrinology & Metabolism, Department of Internal Medicine; and.; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

Publikováno v: JCI insight [JCI Insight] 2023 Dec 22; Vol. 8 (24). Date of Electronic Publication: 2023 Dec 22.

Ghrelin does not impact the blunted counterregulatory response to recurrent hypoglycemia in mice.

Autor: Shankar K; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States., Varshney S; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States., Gupta D; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States., Mani BK; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States., Osborne-Lawrence S; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States., Metzger NP; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States., Richard CP; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States., Zigman JM; Center for Hypothalamic Research, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.; Division of Endocrinology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, United States.; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States.

Publikováno v: Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2023 Jun 02; Vol. 14, pp. 1181856. Date of Electronic Publication: 2023 Jun 02 (Print Publication: 2023).

LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue.

Autor: Shankar K; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Metzger NP; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Singh O; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Mani BK; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Osborne-Lawrence S; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Varshney S; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Gupta D; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Ogden SB; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Takemi S; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Richard CP; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA., Nandy K; Division of Biostatistics, Department of Population and Data Sciences, UT Southwestern Medical Center, Dallas, TX, USA., Liu C; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA; Department of Neuroscience, UT Southwestern Medical Center, Dallas, TX, USA., Zigman JM; Center for Hypothalamic Research, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA; Division of Endocrinology, Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA; Department of Psychiatry, UT Southwestern Medical Center, Dallas, TX, USA. Electronic address: jeffrey.zigman@utsouthwestern.edu.

Publikováno v: Molecular metabolism [Mol Metab] 2021 Nov; Vol. 53, pp. 101327. Date of Electronic Publication: 2021 Aug 21.