Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Richard C.A. Sainson"'
Autor:
Timothy A. Yap, Patricia M. LoRusso, Deborah J. Wong, Siwen Hu-Lieskovan, Kyriakos P. Papadopoulos, Josefin-Beate Holz, Urszula Grabowska, Cristian Gradinaru, Kin-Mei Leung, Sylwia Marshall, Claire S. Reader, Roslin Russell, Richard C.A. Sainson, Claire J. Seal, Christopher J. Shepherd, Fiona Germaschewski, Daniel Gliddon, Omer Stern, Lesley Young, Neil Brewis, Louis Kayitalire, Michelle Morrow
Publikováno v:
Clinical Cancer Research. 29:888-898
Purpose:This phase 1 study (NCT03440437) evaluated the safety, tolerability, pharmacokinetics (PK), and activity of FS118, a bispecific antibody–targeting LAG-3 and PD-L1, in patients with advanced cancer resistant to anti–PD-(L)1 therapy.Patient
Autor:
Matthew McCourt, Sonia Quaratino, Elisabeth Oelmann, Volker Germaschewski, David Melvin, Ian Kirby, Jamie Campbell, Morgane Lecointre, Robert J. Rowlands, Qi Liang, Vivian W.Y. Wong, Hannah Craig, Hanif Ali, Eleanor J. Pring, Emma Taggart, Lauriane Gamand, Cassie Van Krinks, Stuart Ball, Siobhan O'Leary, Tracey Okell, Kerstin L. Pryke, Simon J. Henderson, Joana Carvalho, Rachael Kimber, Nahida Parveen, Gwenoline Borhis, Miha Kosmac, Anil K. Thotakura, Richard C.A. Sainson
AntilCOS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba1f887a0a35c8e986e2343266bfd90
https://doi.org/10.1158/2326-6066.22543483.v1
https://doi.org/10.1158/2326-6066.22543483.v1
Autor:
Matthew McCourt, Sonia Quaratino, Elisabeth Oelmann, Volker Germaschewski, David Melvin, Ian Kirby, Jamie Campbell, Morgane Lecointre, Robert J. Rowlands, Qi Liang, Vivian W.Y. Wong, Hannah Craig, Hanif Ali, Eleanor J. Pring, Emma Taggart, Lauriane Gamand, Cassie Van Krinks, Stuart Ball, Siobhan O'Leary, Tracey Okell, Kerstin L. Pryke, Simon J. Henderson, Joana Carvalho, Rachael Kimber, Nahida Parveen, Gwenoline Borhis, Miha Kosmac, Anil K. Thotakura, Richard C.A. Sainson
Supplementary Figures 1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e902185bdfb8b67303be2284d9cf03dc
https://doi.org/10.1158/2326-6066.22543489.v1
https://doi.org/10.1158/2326-6066.22543489.v1
Autor:
Matthew McCourt, Sonia Quaratino, Elisabeth Oelmann, Volker Germaschewski, David Melvin, Ian Kirby, Jamie Campbell, Morgane Lecointre, Robert J. Rowlands, Qi Liang, Vivian W.Y. Wong, Hannah Craig, Hanif Ali, Eleanor J. Pring, Emma Taggart, Lauriane Gamand, Cassie Van Krinks, Stuart Ball, Siobhan O'Leary, Tracey Okell, Kerstin L. Pryke, Simon J. Henderson, Joana Carvalho, Rachael Kimber, Nahida Parveen, Gwenoline Borhis, Miha Kosmac, Anil K. Thotakura, Richard C.A. Sainson
Metadata for the 5 NSCLC patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1800b3397d3acb7f2682b1bdbfbacca6
https://doi.org/10.1158/2326-6066.22543474.v1
https://doi.org/10.1158/2326-6066.22543474.v1
Autor:
Matthew McCourt, Sonia Quaratino, Elisabeth Oelmann, Volker Germaschewski, David Melvin, Ian Kirby, Jamie Campbell, Morgane Lecointre, Robert J. Rowlands, Qi Liang, Vivian W.Y. Wong, Hannah Craig, Hanif Ali, Eleanor J. Pring, Emma Taggart, Lauriane Gamand, Cassie Van Krinks, Stuart Ball, Siobhan O'Leary, Tracey Okell, Kerstin L. Pryke, Simon J. Henderson, Joana Carvalho, Rachael Kimber, Nahida Parveen, Gwenoline Borhis, Miha Kosmac, Anil K. Thotakura, Richard C.A. Sainson
Isotype control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4666fafa648372d124a70fb2d8120a28
https://doi.org/10.1158/2326-6066.22543480
https://doi.org/10.1158/2326-6066.22543480
Autor:
Matthew McCourt, Sonia Quaratino, Elisabeth Oelmann, Volker Germaschewski, David Melvin, Ian Kirby, Jamie Campbell, Morgane Lecointre, Robert J. Rowlands, Qi Liang, Vivian W.Y. Wong, Hannah Craig, Hanif Ali, Eleanor J. Pring, Emma Taggart, Lauriane Gamand, Cassie Van Krinks, Stuart Ball, Siobhan O'Leary, Tracey Okell, Kerstin L. Pryke, Simon J. Henderson, Joana Carvalho, Rachael Kimber, Nahida Parveen, Gwenoline Borhis, Miha Kosmac, Anil K. Thotakura, Richard C.A. Sainson
Figure and tables legends of supplementary data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e724c6e6d036f84baa17890e6f1a08a
https://doi.org/10.1158/2326-6066.22543492
https://doi.org/10.1158/2326-6066.22543492
Autor:
Matthew McCourt, Sonia Quaratino, Elisabeth Oelmann, Volker Germaschewski, David Melvin, Ian Kirby, Jamie Campbell, Morgane Lecointre, Robert J. Rowlands, Qi Liang, Vivian W.Y. Wong, Hannah Craig, Hanif Ali, Eleanor J. Pring, Emma Taggart, Lauriane Gamand, Cassie Van Krinks, Stuart Ball, Siobhan O'Leary, Tracey Okell, Kerstin L. Pryke, Simon J. Henderson, Joana Carvalho, Rachael Kimber, Nahida Parveen, Gwenoline Borhis, Miha Kosmac, Anil K. Thotakura, Richard C.A. Sainson
The immunosuppressive tumor microenvironment constitutes a significant hurdle to immune checkpoint inhibitor responses. Both soluble factors and specialized immune cells, such as regulatory T cells (Treg), are key components of active intratumoral im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::079b3a5625eeaea7fd185b7366ab732c
https://doi.org/10.1158/2326-6066.c.6550282
https://doi.org/10.1158/2326-6066.c.6550282
Autor:
Matthew McCourt, Sonia Quaratino, Elisabeth Oelmann, Volker Germaschewski, David Melvin, Ian Kirby, Jamie Campbell, Morgane Lecointre, Robert J. Rowlands, Qi Liang, Vivian W.Y. Wong, Hannah Craig, Hanif Ali, Eleanor J. Pring, Emma Taggart, Lauriane Gamand, Cassie Van Krinks, Stuart Ball, Siobhan O'Leary, Tracey Okell, Kerstin L. Pryke, Simon J. Henderson, Joana Carvalho, Rachael Kimber, Nahida Parveen, Gwenoline Borhis, Miha Kosmac, Anil K. Thotakura, Richard C.A. Sainson
Genes used to define Immune cell subtypes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2e881e349e2a4082e5fe260954d2f0
https://doi.org/10.1158/2326-6066.22543477
https://doi.org/10.1158/2326-6066.22543477
Autor:
Robert W. Wilkinson, Simon J. Dovedi, Ross Stewart, Viia Valge-Archer, Michelle Morrow, James A. Harper, Hazel Jones, Matthew McCourt, Brandon W. Higgs, Philip Brohawn, Jane Coates Ulrichsen, Amanda Watkins, Judith Anderton, Danielle Marcus, Luciano Pacelli, Stefanie Mullins, Rebecca Leyland, Miika J. Ahdesmaki, Danielle M. Greenawalt, Dennis Y.Q. Wang, Jens-Oliver Koopmann, Richard C.A. Sainson, John E. Prime, Suzanne I.S. Mosely
Murine syngeneic tumor models are critical to novel immuno-based therapy development, but the molecular and immunologic features of these models are still not clearly defined. The translational relevance of differences between the models is not fully
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::adcb199105c771e6b82b33f00095d352
https://doi.org/10.1158/2326-6066.c.6548411.v1
https://doi.org/10.1158/2326-6066.c.6548411.v1
Autor:
Robert W. Wilkinson, Simon J. Dovedi, Ross Stewart, Viia Valge-Archer, Michelle Morrow, James A. Harper, Hazel Jones, Matthew McCourt, Brandon W. Higgs, Philip Brohawn, Jane Coates Ulrichsen, Amanda Watkins, Judith Anderton, Danielle Marcus, Luciano Pacelli, Stefanie Mullins, Rebecca Leyland, Miika J. Ahdesmaki, Danielle M. Greenawalt, Dennis Y.Q. Wang, Jens-Oliver Koopmann, Richard C.A. Sainson, John E. Prime, Suzanne I.S. Mosely
Supplementary Figure S1: Summary of experiments Supplementary Figure S2: Gating strategy Supplementary Figure S3:Profiling by array CGH, whole-exome and targeted sequencing Supplementary Figure S4: Comparison of mutational profiles of murine syngenei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f963acbe001e8dcef590d845d2ff257
https://doi.org/10.1158/2326-6066.22537352.v1
https://doi.org/10.1158/2326-6066.22537352.v1