Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Richard C. Welch"'
Autor:
Julie Bejoy, Justin M. Farry, Jennifer L. Peek, Mariana C. Cabatu, Felisha M. Williams, Richard C. Welch, Eddie S. Qian, Lauren E. Woodard
Publikováno v:
Stem Cell Research & Therapy, Vol 13, Iss 1, Pp 1-14 (2022)
Abstract Background In diabetic kidney disease, high glucose damages specialized cells called podocytes that filter blood in the glomerulus. In vitro culture of podocytes is crucial for modeling of diabetic nephropathy and genetic podocytopathies and
Externí odkaz:
https://doaj.org/article/0b55a744ffa147448725ac956f0458bf
Autor:
Lauren E. Woodard, Richard C. Welch, Ruth Ann Veach, Thomas M. Beckermann, Feng Sha, Edward J. Weinman, Talat Alp Ikizler, Jay A. Tischfield, Amrik Sahota, Matthew H. Wilson
Publikováno v:
BMC Nephrology, Vol 20, Iss 1, Pp 1-9 (2019)
Abstract Background Cystinuria is an inherited disorder of renal amino acid transport that causes recurrent nephrolithiasis and significant morbidity in humans. It has an incidence of 1 in 7000 worldwide making it one of the most common genetic disor
Externí odkaz:
https://doaj.org/article/34f494f6358f467691d7f610d71a6800
Autor:
Richard T. O’Neil, Sunandan Saha, Ruth Ann Veach, Richard C. Welch, Lauren E. Woodard, Cliona M. Rooney, Matthew H. Wilson
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Delivery of therapeutic proteins to patients may be costly to administer, and often requires repeated injections. Here, the authors use antigen-specific T cells expressing erythropoietin, and show that following transfer in mice, cell expansion and e
Externí odkaz:
https://doaj.org/article/1b801fcca3ce4879a9a7f67891d2af75
Autor:
Lauren E. Woodard, Ruth Ann Veach, Sunandan Saha, Richard T. O’Neil, Cliona M. Rooney, Matthew H. Wilson, Richard C. Welch
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
A cell therapy platform permitting long-term delivery of peptide hormones in vivo would be a significant advance for patients with hormonal deficiencies. Here we report the utility of antigen-specific T lymphocytes as a regulatable peptide delivery p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9435b3ca3f6fd4f3b1af02b239f08a
https://doi.org/10.1038/s41467-018-03787-8
https://doi.org/10.1038/s41467-018-03787-8
Autor:
Carlos G. Vanoye, Britt-Marie Berling, Alfred L. George, Richard C. Welch, Gabor Bunford, Jon M. Tuveng, Torleiv O. Rognum, Trond P. Leren
We report a case of a woman who experienced intrauterine fetal death at full term pregnancy, and then died suddenly soon after learning about the death of her fetus. At autopsy, previously undiagnosed neurofibromatosis and an adrenal gland pheochromo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67dd196afcab3c7778568d5c3e6aaeef
http://hdl.handle.net/10852/66536
http://hdl.handle.net/10852/66536
Autor:
Matthew H. Wilson, Sunandan Saha, Cliona M. Rooney, Elizabeth M. Charron, Lauren E. Woodard, Richard C. Welch
Publikováno v:
Nucleic Acids Research
Non-viral transposons have been used successfully for genetic modification of clinically relevant cells including embryonic stem, induced pluripotent stem, hematopoietic stem and primary human T cell types. However, there has been limited evaluation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f70de52899d62576a72c11898b1c85f6
https://doi.org/10.1093/nar/gkv017
https://doi.org/10.1093/nar/gkv017
Autor:
Lauren J. Manderfield, Carlos G. Vanoye, Melissa A. Daniels, Richard C. Welch, Alfred L. George, Charles R. Sanders, Andrew R. Tapper
Publikováno v:
The Journal of General Physiology
Modulation of voltage-gated potassium (KV) channels by the KCNE family of single transmembrane proteins has physiological and pathophysiological importance. All five KCNE proteins (KCNE1–KCNE5) have been demonstrated to modulate heterologously expr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfbaf6d6c314e6749f6685038131adee
https://doi.org/10.1085/jgp.200910234
https://doi.org/10.1085/jgp.200910234
Autor:
Richard C. Welch, Charles R. Sanders, Carlos G. Vanoye, Hak Jun Kim, Changlin Tian, Alfred L. George, CongBao Kang
Publikováno v:
Biochemistry. 46:11459-11472
KCNE1, also known as minK, is a member of the KCNE family of membrane proteins that modulate the function of KCNQ1 and certain other voltage-gated potassium channels (KV). Mutations in human KCNE1 cause congenital deafness and congenital long QT synd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ff71683e2a3f051cc5384298a4bbfa
https://doi.org/10.1021/bi700705j
https://doi.org/10.1021/bi700705j
Publikováno v:
Molecular Therapy. 23
DNA transposons such as piggyBac and Sleeping Beauty employ a cut-and-paste mechanism of transposition that has proven effective for numerous gene transfer and cellular reprogramming applications. Therapeutic transposons are carried into cells usuall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15aa7f8c9ea27d8d7ccc9f600dafd676
Voltage-gated potassium (K(V)) channels, such as KCNQ1 (K(V)7.1), are modulated by accessory subunits and regulated by intracellular second messengers. Accessory subunits belonging to the KCNE family exert diverse functional effects on KCNQ1, have be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8d5746fb92d4d069ab96f96c367ab3e
https://europepmc.org/articles/PMC3039368/
https://europepmc.org/articles/PMC3039368/