Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Richard C. Turkington"'
Autor:
James Holloway, Aidan Seeley, Neville Cobbe, Richard C. Turkington, Daniel B. Longley, Emma Evergren
Publikováno v:
Cell Death and Disease, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The activation of apoptosis signalling by TRAIL (TNF-related apoptosis-inducing ligand) through receptor binding is a fundamental mechanism of cell death induction and is often perturbed in cancer cells to enhance their cell survival and tre
Externí odkaz:
https://doaj.org/article/53ac8990bc0c4e5581f8cb78a56ff4b9
Autor:
Shereen El Mashed, Tracey R. O’Donovan, Elaine Kay, Anthony O’Grady, Damian McManus, Richard C. Turkington, Sharon L. McKenna
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract Background Less than 20 % of patients with resectable oesophageal adenocarcinoma obtain a pathological response following neoadjuvant chemotherapy. Studies using oesophageal cancer cell lines have shown that drug sensitive tumour cells under
Externí odkaz:
https://doaj.org/article/e953a1bbf3464b02bb9dc594e49fa04a
Autor:
Kieran G. Foley, Anita Lavery, Eoin Napier, David Campbell, Martin M. Eatock, Richard D. Kennedy, Kevin M. Bradley, Richard C. Turkington
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract 18F-fluorodeoxyglucose PET-CT may guide treatment decisions in patients with oesophageal adenocarcinoma (OAC). This study evaluated the added value of maximum standardised uptake value (SUVmax) to a novel DNA-damage immune response (DDIR) as
Externí odkaz:
https://doaj.org/article/335f4a45c8e3412591391e3d999c13de
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-17 (2021)
Abstract Background Surgical resection remains the only curative treatment for pancreatic cancer and is associated with significant post-operative morbidity and mortality. Patients eligible for surgery, increasingly receive neo-adjuvant therapy befor
Externí odkaz:
https://doaj.org/article/71bc3648697d49ed9de74bae8d5f59d0
Autor:
Matthew P. Humphries, Stephanie G. Craig, Rafal Kacprzyk, Natalie C. Fisher, Victoria Bingham, Stephen McQuaid, Graeme I. Murray, Damian McManus, Richard C. Turkington, Jacqueline James, Manuel Salto-Tellez
Publikováno v:
BMC Cancer, Vol 20, Iss 1, Pp 1-11 (2020)
Abstract Background Limited studies examine the immune landscape in Esophageal Adenocarcinoma (EAC). We aim to identify novel associations, which may inform immunotherapy treatment stratification. Methods Three hundred twenty-nine EAC cases were avai
Externí odkaz:
https://doaj.org/article/835b6b88f74b4c999fdf8a0998cc6c0a
The activation of apoptosis signalling by TRAIL (TNF-related apoptosis-inducing ligand) through receptor binding is a fundamental mechanism of cell death induction and is often perturbed in cancer cells to enhance their cell survival and treatment re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d220b3185dd46aa0329775690df0eba0
https://doi.org/10.1101/2023.05.10.540247
https://doi.org/10.1101/2023.05.10.540247
Autor:
Patrick G. Johnston, Daniel B. Longley, Sandra Van Schaeybroeck, Philip Dunne, Suzanne Hector, Vicky M. Coyle, Gail Carson, Leanne Stevenson, Richard C. Turkington, Wendy L. Allen
PDF file - 261K, List showing 1986 genes that are uniquely altered following SN38 treatment over time in HCT116 p53null cells only. Genes have been normalised and filtered as stated in the materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e5f692e6164e59aac2080c4a376a52
https://doi.org/10.1158/1535-7163.22498386.v1
https://doi.org/10.1158/1535-7163.22498386.v1
Autor:
Patrick G. Johnston, Daniel B. Longley, Sandra Van Schaeybroeck, Philip Dunne, Suzanne Hector, Vicky M. Coyle, Gail Carson, Leanne Stevenson, Richard C. Turkington, Wendy L. Allen
PDF file - 321K, List showing 2544 genes that are uniquely altered following SN38 treatment over time in HCT116 p53wild-type cells only. Genes have been normalised and filtered as stated in the materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d9d0b68b7e9ec6cccc8e0ae2561b94c
https://doi.org/10.1158/1535-7163.22498389.v1
https://doi.org/10.1158/1535-7163.22498389.v1
Autor:
Patrick G. Johnston, Daniel B. Longley, Sandra Van Schaeybroeck, Philip Dunne, Suzanne Hector, Vicky M. Coyle, Gail Carson, Leanne Stevenson, Richard C. Turkington, Wendy L. Allen
PDF file - 132K, List showing 752 genes that are commonly altered following SN38 treatment over time in isogenic HCT116 p53wild-type and HCT116 p53null cells. Genes have been normalised and filtered as stated in the materials and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c34fa5c36b5847e4210dea0939589e
https://doi.org/10.1158/1535-7163.22498392
https://doi.org/10.1158/1535-7163.22498392
Autor:
Patrick G. Johnston, Daniel B. Longley, Sandra Van Schaeybroeck, Philip Dunne, Suzanne Hector, Vicky M. Coyle, Gail Carson, Leanne Stevenson, Richard C. Turkington, Wendy L. Allen
PDF file - 35K, Real-time PCR validation of HCT116 p53 null cells following treatment with 5nM SN38 for 6, 12 and 24h. This table shows the Pearson's correlation and p values for each individual gene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cfedc8602ea4d4d828fc3f08905cbe7
https://doi.org/10.1158/1535-7163.22498377
https://doi.org/10.1158/1535-7163.22498377