Zobrazeno 1 - 10 of 17 pro vyhledávání: '"Richard C. Peffer"'
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Minimum datasets to establish a CAR-mediated mode of action for rodent liver tumors
Autor: Michael Battalora, Werner H. Bomann, M. Aggarwal, Richard C. Peffer, Matthew J. LeBaron, Helen Tinwell, Christoph Werner, Rocky R. Rowe
Publikováno v: Regulatory Toxicology and Pharmacology. 96:106-120
Methods for investigating the Mode of Action (MoA) for rodent liver tumors via constitutive androstane receptor (CAR) activation are outlined here, based on current scientific knowledge about CAR and feedback from regulatory agencies globally. The ke
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::436308cc441e4da351abf6c05b0a16d9
https://doi.org/10.1016/j.yrtph.2018.04.001
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4
Dermal absorption for pesticide health risk assessment: Harmonization of study design and data reporting for North American Regulatory submissions
Autor: Eric Fabian, M. Aggarwal, Richard C. Peffer, Kristie Sullivan, Jon R. Heylings, C. Wiemann, Prakashchandra P V Shah, Jonathan M Akins, Hans Raabe
Publikováno v: Regulatory Toxicology and Pharmacology. 90:197-205
Although an internationally-adopted in vitro dermal absorption test guideline is available (OECD Test Guideline 428), the replacement of the in vivo approach in North America for pesticide formulations has not occurred due to concern over the reliabi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3b376ffb9daf75908616a9ababfa57d
https://doi.org/10.1016/j.yrtph.2017.09.012
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5
A predictive data-driven framework for endocrine prioritization: a triazole fungicide case study
Autor: M. Sue Marty, Ann M. Blacker, Katie Paul Friedman, Richard C. Peffer, Pat Kwiatkowski, Reza J. Rasoulpour, Douglas C. Wolf, Sabitha Papineni, Amber K. Goetz, Kun Don Yi
Publikováno v: Critical Reviews in Toxicology
The US Environmental Protection Agency Endocrine Disruptor Screening Program (EDSP) is a tiered screening approach to determine the potential for a chemical to interact with estrogen, androgen, or thyroid hormone systems and/or perturb steroidogenesi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e6a2c8cb891524aa18654021dc903a
https://doi.org/10.1080/10408444.2016.1193722
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6
A critical review of neonicotinoid insecticides for developmental neurotoxicity
Autor: Richard C. Peffer, Moire R. Creek, Daniel J. Minnema, Abby A. Li, Larry P. Sheets, Richard H. Collier
Publikováno v: Critical Reviews in Toxicology
A comprehensive review of published and previously unpublished studies was performed to evaluate the neonicotinoid insecticides for evidence of developmental neurotoxicity (DNT). These insecticides have favorable safety profiles, due to their prefere
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c323f7ee7deba7d20489e14f111b56
https://doi.org/10.3109/10408444.2015.1090948
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7
Sedaxane-Use of Nuclear Receptor Transactivation Assays, Toxicogenomics, and Toxicokinetics as Part of a Mode of Action Framework for Rodent Liver Tumors
Autor: Richard C. Peffer, David Cowie, Daniel J. Minnema, Richard A. Currie
Publikováno v: Toxicological sciences : an official journal of the Society of Toxicology. 162(2)
Experimental data demonstrate a mode of action (MOA) for liver tumors in male rats and mice treated with sedaxane that starts with activation of CAR, followed by altered expression of CAR-responsive genes, increased cell proliferation, and eventually
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7388219c454d73564fd82c39e1c3f7e
https://pubmed.ncbi.nlm.nih.gov/29244179
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8
Development of an in vitro high content imaging assay for quantitative assessment of CAR-dependent mouse, rat, and human primary hepatocyte proliferation
Autor: Edward L. LeCluyse, Chad Deisenroth, Richard C. Peffer, Melvin E. Andersen, Valerie Y. Soldatow, David Cowie, O. Joseph Trask
Publikováno v: Toxicology in vitro : an international journal published in association with BIBRA. 36
Rodent liver tumors promoted by constitutive androstane receptor (CAR) activation are known to be mediated by key events that include CAR-dependent gene expression and hepatocellular proliferation. Here, an in vitro high content imaging based assay w
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01852d0c45a7656f070516f7545ee89
https://pubmed.ncbi.nlm.nih.gov/27530964
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9
Multi-species Analyses of Direct Activators of the Constitutive Androstane Receptor
Autor: Richard C. Peffer, Tao Chen, Elizabeth M. Laurenzana, Curtis J. Omiecinski, Denise M. Coslo
Publikováno v: Toxicological Sciences. 123:550-562
The constitutive androstane receptor (CAR; NR1I3) is a member of the nuclear receptor superfamily and functions as an important xenochemical sensor and transcriptional modulator in mammalian cells. Upon chemical activation, CAR undergoes nuclear tran
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffacf38e60a53051dee349dd5d371c4c
https://doi.org/10.1093/toxsci/kfr191
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10
Thiamethoxam Induced Mouse Liver Tumors and Their Relevance to Humans
Autor: Robert Lee, Mervyn Robinson, Edgar Weber, Richard C. Peffer, Felix Waechter, Alison Toghill, Trevor Green, James Noakes
Publikováno v: Toxicological Sciences. 86:48-55
Thiamethoxam is a neonicotinoid insecticide that is not a mutagen, but it did cause a significant increase in liver cancer in mice, but not rats, in chronic dietary feeding studies. Previous studies in mice have characterized a carcinogenicity mode o
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b19bb29b75e899aa904501064cb613f7
https://doi.org/10.1093/toxsci/kfi125
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