Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Richard C. Oglesby"'
Publikováno v:
The Journal of Organic Chemistry. 59:5828-5832
Autor:
F. J. Dutko, J. Wetzel, Niranjan Vescio, Theodore J. Nitz, V. Giranda, Deborah Volkots, David Cutcliffe, Richard C. Oglesby, D. C. Pevear, John P. Mallamo, Guy D. Diana, Thomas R. Bailey
Publikováno v:
ChemInform. 25
Publikováno v:
ChemInform. 26
Autor:
Richard C. Oglesby, Daniel C. Pevear, Adi Treasurywala, Paul J. Kowalczyk, Guy D. Diana, Frank J. Dutko
Publikováno v:
Journal of Medicinal Chemistry. 35:1002-1008
A CoMFA analysis of eight compounds related to disoxaril whose X-ray structures bound to HRV-14 had been determined resulted in a strong positive correlation of activity with steric effects of the compounds, particularly toward the pore end of the co
Autor:
Daniel C. Pevear, Thomas R. Bailey, Frank J. Dutko, Adi Treasurywala, Richard C. Oglesby, Guy D. Diana
Publikováno v:
Journal of medicinal chemistry. 33(5)
A number of (oxazolinylphenyl)isoxazoles have been synthesized and tested against human rhinovirus-14 (HRV-14). Several of the more active compounds have been examined by X-ray crystallography and their orientation in the compound binding site on the
Autor:
Frank J. Dutko, Daniel C. Pevear, Paul J. Kowalczyk, Adi Treasurywala, Guy D. Diana, Richard C. Oglesby
Publikováno v:
Journal of Medicinal Chemistry. 35:4768-4768
Autor:
Michael J. Otto, Mark A. McKinlay, Thomas J. Smith, Michael G. Rossmann, Edward G. Maliski, Adi Treasurywala, Guy D. Diana, Richard C. Oglesby
Publikováno v:
Journal of medicinal chemistry. 31(3)
X-ray crystallography studies of racemic 5-[7-[4-(4,5-dihydro-4-methyl-2-oxazolyl)phenoxy]heptyl]- 3-methylisoxazole bound to human rhinovirus-14 (HRV-14) indicate selective binding of the S isomer. This result correlates well with the 10-fold greate
Autor:
Richard C. Oglesby, Michael J. Otto, David Cutcliffe, Mark A. McKinlay, Guy D. Diana, Vahan Akullian, John P. Mallamo
Publikováno v:
Journal of medicinal chemistry. 32(2)
A number of 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated against several rhinovirus serotypes. A QSAR study revealed that the mean MIC (MIC) against five rhinovirus serotypes corr
Autor:
Edward G. Maliski, Philip M. Carabateas, John P. Mallamo, Guy D. Diana, Vahan Akullian, Stephen J. Michalec, Richard C. Oglesby, David Cutcliffe, Michael J. Otto, Mark A. McKinlay
Publikováno v:
Journal of medicinal chemistry. 30(2)
A series of substituted phenyl analogues of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles has been synthesized and evaluated in vitro against several human rhinovirus (HRV) serotypes. Substituents in the 2-position greatly enhanced
Autor:
Philip M. Carabateas, Edward G. Maliski, Richard C. Oglesby, Michael J. Otto, Mark A. McKinlay, John P. Mallamo, Guy D. Diana, David Cutcliffe, Stephen J. Michalec, Vahan Akullian
Publikováno v:
ChemInform. 18
A series of substituted phenyl analogues of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles has been synthesized and evaluated in vitro against several human rhinovirus (HRV) serotypes. Substituents in the 2-position greatly enhanced