Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Richard C. Marcellus"'
Autor:
Lamis Hammoud, Jessica R. Adams, Amanda J. Loch, Richard C. Marcellus, David E. Uehling, Ahmed Aman, Christopher Fladd, Trevor D. McKee, Christine E.B. Jo, Rima Al-Awar, Sean E. Egan, Janet Rossant
Publikováno v:
Stem Cell Reports, Vol 7, Iss 4, Pp 787-801 (2016)
Blood vessels are formed through vasculogenesis, followed by remodeling of the endothelial network through angiogenesis. Many events that occur during embryonic vascular development are recapitulated during adult neoangiogenesis, which is critical to
Externí odkaz:
https://doaj.org/article/f367a2280ad24a8bb8a37991fcb032fa
Publikováno v:
Cancer Research. 81:1222-1222
Lung cancer is the most lethal cancer globally, accounting for 1.8 million deaths in 2018. Presently, there is a need for novel targets for the development of improved therapeutics. Data mining through genetic screens suggested that Cell Division Cyc
Autor:
Mansi K. Aparnathi, Rima Al-awar, Lifang Song, Ratheesh Subramaniam, Richard C. Marcellus, Benjamin H. Lok
Publikováno v:
Cancer Research. 79:3925-3925
Objective: Small cell lung cancer (SCLC) is a highly aggressive neuroendocrine malignancy. Post-platinum-based chemotherapy, rapid relapse of chemoresistant tumor is commonly seen. Unidentifiable causative mutations and from reversible nature of acqu
Autor:
Zhiying Zhang, Melissa Z. Mui, Albert M. Berghuis, Philip E. Branton, Paola Blanchette, Suiyang Li, Francine Chan, Diana E. Roopchand, Richard C. Marcellus
Publikováno v:
Journal of Virology. 85:286-295
The human adenovirus E4orf4 protein is toxic in both human tumor cells and Saccharomyces cerevisiae . Previous studies indicated that most of this toxicity is dependent on an interaction of E4orf4 protein with the B55 class of regulatory subunits of
Publikováno v:
ChemBioChem. 11:1583-1593
SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a Ki of less than 600 pM.
Autor:
Philip E. Branton, Suiyang Li, Marie-Joëlle Miron, Olivier Binda, Helen Chan, Richard C. Marcellus, David C. Pallas, Danita G. Ashby, Claudine Brignole, Sara Thirlwell, Zhiying Zhang, Monica McQuoid
Publikováno v:
Journal of Virology. 83:8340-8352
Human adenovirus E4orf4 protein is toxic in human tumor cells. Its interaction with the Bα subunit of protein phosphatase 2A (PP2A) is critical for cell killing; however, the effect of E4orf4 binding is not known. Bα is one of several mammalian B-t
Autor:
Rachel Sarig, Iris Kamer, Yehudit Zaltsman, Richard C. Marcellus, Limor Regev, Yaniv Lerenthal, Gal Haimovich, Hagit Niv, Atan Gross, Galia Oberkovitz
Publikováno v:
Cell. 122:593-603
SummaryThe “BH3-only” proapoptotic BCL-2 family members are sentinels of intracellular damage. Here, we demonstrated that the BH3-only BID protein partially localizes to the nucleus in healthy cells, is important for apoptosis induced by DNA dama
Publikováno v:
The Journal of Cell Biology
Stimulation of cell surface death receptors activates caspase-8, which targets a limited number of substrates including BAP31, an integral membrane protein of the endoplasmic reticulum (ER). Recently, we reported that a caspase-resistant BAP31 mutant
Publikováno v:
Oncogene. 21:2534-2544
A DNA microarray analysis identified the BH3-only BCL-2 family member, BIK/NBK, as a transcript that is upregulated during induction of apoptosis by oncogenic E1A. E1A depended on wild-type p53 to induce BIK and activate the death program. Further, p
Publikováno v:
Oncogene. 18:2091-2100
Growth arrest and cell cycle progression are regulated by the retinoblastoma tumour suppressor pRB and related proteins p130 and p107 that bind to and inhibit the E2F family of transcription factors. Although the precise mechanism of this inhibition