Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Richard C. M. Butler"'
Publikováno v:
Journal of Heterocyclic Chemistry. 22:177-181
An investigation into the synthesis of benzoxazine, benzoxathiane and benzothiazine derivatives of 2-(2-imidazolinyl)-1,4-benzodioxane has been carried out.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf044d6eed62f5e5afed6ba8d00d2f6b
https://doi.org/10.1002/jhet.5570220143
https://doi.org/10.1002/jhet.5570220143
Autor:
Richard C. M. Butler, Peter Myers, Alan Geoffrey Roach, Colin Smith, John C. Doxey, Christopher B. Chapleo
Publikováno v:
Journal of Medicinal Chemistry. 26:823-831
The rational design of RX 781094, 2-(1,4-benzodioxan-2-yl)-2-imidazoline hydrochloride (5), a new potent and selective antagonist of alpha 2-adrenoreceptors, is discussed. A compound that acts as an antagonist at presynaptic alpha 2-adrenoreceptors c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1930043f26a4fbe3de499b5c41d38155
https://doi.org/10.1021/jm00360a008
https://doi.org/10.1021/jm00360a008
Autor:
Richard C. M. Butler, C. F. C. Smith, Alan Geoffrey Roach, Christopher B. Chapleo, J. A. Davis, John C. Doxey, Peter Myers, Michael R. Stillings, S. D. Higgins, Malcolm Myers
Publikováno v:
Journal of Medicinal Chemistry. 27:570-576
Modification of the 1,4-benzodioxan ring present in RX 781094 has not previously been considered. This paper describes a number of analogues of this ring system, including compounds in which one of the oxygen atoms has been replaced by a methylene gr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931c57d4c228a16c4b285a2202b11110
https://doi.org/10.1021/jm00371a003
https://doi.org/10.1021/jm00371a003
Autor:
Peter Myers, Michael R. Stillings, Christopher B. Chapleo, Richard C. M. Butler, John C. Doxey, C. D. England, Malcolm Myers, Anthony P. Welbourn, N. Tweddle, J. A. Davis
Publikováno v:
Journal of Medicinal Chemistry. 28:1054-1062
The synthesis and pharmacological activity of a series of 2-substituted derivatives of the selective alpha 2-adrenoreceptor antagonist idazoxan (RX 781094) is described. Substitution in this position by alkyl, alkenyl, cycloalkenyl, and alkoxy groups
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a0d41c7caed92b5d783852182ffcb80
https://doi.org/10.1021/jm00146a013
https://doi.org/10.1021/jm00146a013
Autor:
M. Myers, M. R. Stillings, Peter Myers, N. Tweddle, J. A. Davis, John C. Doxey, C. D. England, Richard C. M. Butler, A. P. Welbourn, Christopher B. Chapleo, C. F. C. Smith
Publikováno v:
Chemischer Informationsdienst. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c01f79021adad7597b7ed2001174422e
https://doi.org/10.1002/chin.198548212
https://doi.org/10.1002/chin.198548212
Autor:
M. Myers, Richard C. M. Butler, A. P. Welbourn, Alan Geoffrey Roach, J. A. Davis, John C. Doxey, M. R. Stillings, Christopher B. Chapleo, C. F. C. Smith, Peter Myers, S. D. Higgins
Publikováno v:
Chemischer Informationsdienst. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c4a7ccfb424d6c03adf8eb4fca9dfb4
https://doi.org/10.1002/chin.198443246
https://doi.org/10.1002/chin.198443246
Autor:
Ian F. Tulloch, Christopher B. Chapleo, C. F. C. Smith, Alan Geoffrey Roach, Richard C. M. Butler, Peter Myers, Michael R. Stillings, David C. England
Publikováno v:
Journal of medicinal chemistry. 32(7)
A 1,4-dioxane analogue (1) of the alpha 2-adrenoreceptor partial agonist clonidine (2) has previously been shown to possess an interesting but complex pharmacological profile. In this study, from a series of other heterocyclic analogues of clonidine,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86cdf1c8cbe34b4617ca6082977055ac
https://pubmed.ncbi.nlm.nih.gov/2567783
https://pubmed.ncbi.nlm.nih.gov/2567783