Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Richard C. Hedstrom"'
Autor:
Bradley Hickey, Robin Mere, Sanjai Kumar, Meng Shi, John B. Sacci, Thomas C. Luke, Maria F. Baraceros, Peter Hobart, Lorraine Soisson, Ronald A. Nosek, Jennifer Ng, Judith E. Epstein, Keith Limbach, Yupin Charoenvit, Nancy O. Richie, Ruobing Wang, Mara P. Berzins, Denise L. Doolan, Esteban Abot, Tanya G. Geter, Lolita Bebris, Joao C. Aguiar, Jo Glenna Banania, Richard C. Hedstrom, David E. Lanar, Michael R. Hollingdale, William O. Rogers, Daniel Freilich, Harini Ganeshan, Victoria Majam, Martha Sedegah, Thomas L. Richie, Patricia de la Vega, Stephen L. Hoffman, Jon Norman
Publikováno v:
Human Vaccines & Immunotherapeutics
When introduced in the 1990s, immunization with DNA plasmids was considered potentially revolutionary for vaccine development, particularly for vaccines intended to induce protective CD8 T cell responses against multiple antigens. We conducted, in 19
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3349b913bc019d182aeda4a155241fa
http://europepmc.org/articles/PMC3601132
http://europepmc.org/articles/PMC3601132
Autor:
Martha Sedegah, Arnel Belmonte, Thomas L. Richie, John B. Sacci, Daniel J. Carucci, Yupin Charoenvit, J. E. Epstein, David E. Lanar, Sanjai Kumar, Pierre Druilhe, Richard C. Hedstrom, Giampietro Corradin, Stephen L. Hoffman, Trevor R. Jones, Joao C. Aguiar, Esteban Abot
Publikováno v:
Genes & Immunity. 5:553-561
One potential benefit of DNA vaccines is the capacity to elicit antibody and T-cell responses against multiple antigens at the same time by mixing plasmids expressing different proteins. A possible negative effect of such mixing is interference among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d770f027a63db8ef235c6d317ab1a15d
https://doi.org/10.1038/sj.gene.6364125
https://doi.org/10.1038/sj.gene.6364125
Autor:
Suezanne E. Parker, Yupin Charoenvit, Jon Norman, Judith E. Epstein, John Nerges, Ruobing Wang, Lucy M. L. Goh, Sanjai Kumar, Richard Stout, Stephen L. Hoffman, Jennifer Ng, Edward J. Gorak, Richard C. Hedstrom, Nicole Freydberg, Esteban Abot, Fernando Trespalacios, Thomas L. Richie, Oluwatoyin Osinowo, Victoria Fallarme-Majam, Erin L. Stoltz
Publikováno v:
Human Gene Therapy. 13:1551-1560
Introduction of a new vaccine requires choosing a delivery system that provides safe administration and the desired level of immunogenicity. The safety, tolerability, and immunogenicity of three monthly 2.5-mg doses of a PfCSP DNA vaccine were evalua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e904c86714a8b4dcbedfb2399d873b3a
https://doi.org/10.1089/10430340260201644
https://doi.org/10.1089/10430340260201644
Autor:
Ruobing Wang, Judith Epstein, Fe Maria Baraceros, Edward J. Gorak, Yupin Charoenvit, Daniel J. Carucci, Richard C. Hedstrom, Nancy Rahardjo, Tanya Gay, Peter Hobart, Rick Stout, Trevor R. Jones, Thomas L. Richie, Suezanne E. Parker, Denise L. Doolan, Jon Norman, Stephen L. Hoffman
Publikováno v:
Proceedings of the National Academy of Sciences. 98:10817-10822
We assessed immunogenicity of a malaria DNA vaccine administered by needle i.m. or needleless jet injection [i.m. or i.m./intradermally (i.d.)] in 14 volunteers. Antigen-specific IFN-γ responses were detected by enzyme-linked immunospot (ELISPOT) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514bc72a5dcd05750827f588949097b6
https://doi.org/10.1073/pnas.181123498
https://doi.org/10.1073/pnas.181123498
Autor:
Martha Sedegah, John B. Sacci, Kalpana Gowda, Sanjai Kumar, Victoria Majam, John A. Tine, Peter Hobart, Richard C. Hedstrom, Yupin Charoenvit, Stephen L. Hoffman, Walter R. Weiss
Publikováno v:
The Journal of Immunology. 164:5905-5912
Intramuscular immunization with a naked DNA plasmid expressing the Plasmodium yoelii circumsporozoite protein (pPyCSP) protects mice against challenge with P. yoelii sporozoites. This protection can be improved either by coadministration of a plasmid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc6280cefb0f5b52e14485452e1cf846
https://doi.org/10.4049/jimmunol.164.11.5905
https://doi.org/10.4049/jimmunol.164.11.5905
Autor:
Suezanne E. Parker, Kevin M. Coonan, Yupin Charoenvit, Ruobing Wang, Richard C. Hedstrom, Jason D. Maguire, Peter Hobart, Stephen L. Hoffman, Judith E. Epstein, Thong P. Le, Martha Sedegah, Sanjai Kumar, Denise L. Doolan, Jon Norman
Publikováno v:
Vaccine. 18:1893-1901
DNA-based vaccines are considered to be potentially revolutionary due to their ease of production, low cost, long shelf life, lack of requirement for a cold chain and ability to induce good T-cell responses. Twenty healthy adult volunteers were enrol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4e3a06534e1f92456b0371dc549f415
https://doi.org/10.1016/s0264-410x(99)00407-7
https://doi.org/10.1016/s0264-410x(99)00407-7
Autor:
John A. Tine, Manjit Kaur, Ruobing Wang, Stephen L. Hoffman, Martha Sedegah, Walter R. Weiss, John B. Sacci, Dennis M. Klinman, Peter Hobart, Richard C. Hedstrom, Victoria Fallarme, Yupin Charoenvit, Malcolm J. Gardner, Denise L. Doolan
Publikováno v:
Infection and Immunity. 66:4193-4202
A malaria vaccine will help reduce the 300 million to 500 million new Plasmodium infections and 1.5 million to 2.7 million deaths due to malaria annually (53). Many believe that the ideal vaccine may need to induce protective immunity against all sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d45b4b4ad24c9442daae34095a15f46
https://doi.org/10.1128/iai.66.9.4193-4202.1998
https://doi.org/10.1128/iai.66.9.4193-4202.1998
Autor:
Walter R. Weiss, Ken J. Ishii, Richard C. Hedstrom, Martha Sedegah, Motohide Ichino, Kerry Barnhart, Dennis M. Klinman, Stephen L. Hoffman
Publikováno v:
The Journal of Immunology. 161:2325-2332
Using the murine parasite Plasmodium yoelii (Py) as a model for malaria vaccine development, we have previously shown that a DNA plasmid encoding the Py circumsporozoite protein (PyCSP) can protect mice against sporozoite infection. We now report tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12ef18336754ea04e4b01c6721751c85
https://doi.org/10.4049/jimmunol.161.5.2325
https://doi.org/10.4049/jimmunol.161.5.2325
Autor:
Sylvia I. Becker, Richard C. Hedstrom, Malcolm J. Gardner, Joao C. Aguiar, Stephen L. Hoffman, Ruobing Wang, Trevor R. Jones
Publikováno v:
Infection and Immunity. 66:3457-3461
Immunization of mice with DNA vaccines encoding the full-length form and C and N termini of Plasmodium yoelii merozoite surface protein 1 provided partial protection against sporozoite challenge and resulted in boosting of antibody titers after chall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c223a2e75232f42c875701442063a5b
https://doi.org/10.1128/iai.66.7.3457-3461.1998
https://doi.org/10.1128/iai.66.7.3457-3461.1998
Autor:
Denise L. Doolan, Jon Norman, Thong P. Le, Libia F Scheller, Stephen L. Hoffman, Ruobing Wang, Dennis M. Klinman, Richard C. Hedstrom, Peter Hobart, Martha Sedegah, Anita Kumar, Walter R. Weiss
Publikováno v:
Immunology and Cell Biology. 75:376-381
In mid 1997 the first malaria DNA vaccine will enter clinical trials. This single gene DNA vaccine encoding the Plasmodium falciparum circumsporozoite protein (PfCSP) will be studied for safety and immunogenicity. If these criteria are met, a multi-g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35d9084314f9a4968dcc99dbaccf6868
https://doi.org/10.1038/icb.1997.59
https://doi.org/10.1038/icb.1997.59