Zobrazeno 1 - 10
of 145
pro vyhledávání: '"Richard C. Crist"'
Autor:
Benjamin C. Reiner, Samar N. Chehimi, Riley Merkel, Sylvanus Toikumo, Wade H. Berrettini, Henry R. Kranzler, Sandra Sanchez-Roige, Rachel L. Kember, Heath D. Schmidt, Richard C. Crist
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Neural processing of rewarding stimuli involves several distinct regions, including the nucleus accumbens (NAc). The majority of NAc neurons are GABAergic projection neurons known as medium spiny neurons (MSNs). MSNs are broadly defined by d
Externí odkaz:
https://doaj.org/article/4327a3ae17324eff8169e5f06fa6237b
Autor:
Weili Ma, Maria Cecília Oliveira-Nunes, Ke Xu, Andrew Kossenkov, Benjamin C. Reiner, Richard C. Crist, James Hayden, Qing Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract Cancer metastasis to the brain is a significant clinical problem. Metastasis is the consequence of favorable interactions between invaded cancer cells and the microenvironment. Here, we demonstrate that cancer-activated astrocytes create a s
Externí odkaz:
https://doaj.org/article/c50d61d0f5a74a329e60705f1e43cf8e
Autor:
Nathan Gaddis, Ravi Mathur, Jesse Marks, Linran Zhou, Bryan Quach, Alex Waldrop, Orna Levran, Arpana Agrawal, Matthew Randesi, Miriam Adelson, Paul W. Jeffries, Nicholas G. Martin, Louisa Degenhardt, Grant W. Montgomery, Leah Wetherill, Dongbing Lai, Kathleen Bucholz, Tatiana Foroud, Bernice Porjesz, Valgerdur Runarsdottir, Thorarinn Tyrfingsson, Gudmundur Einarsson, Daniel F. Gudbjartsson, Bradley Todd Webb, Richard C. Crist, Henry R. Kranzler, Richard Sherva, Hang Zhou, Gary Hulse, Dieter Wildenauer, Erin Kelty, John Attia, Elizabeth G. Holliday, Mark McEvoy, Rodney J. Scott, Sibylle G. Schwab, Brion S. Maher, Richard Gruza, Mary Jeanne Kreek, Elliot C. Nelson, Thorgeir Thorgeirsson, Kari Stefansson, Wade H. Berrettini, Joel Gelernter, Howard J. Edenberg, Laura Bierut, Dana B. Hancock, Eric Otto Johnson
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Opioid addiction (OA) is moderately heritable, yet only rs1799971, the A118G variant in OPRM1, has been identified as a genome-wide significant association with OA and independently replicated. We applied genomic structural equation modeling
Externí odkaz:
https://doaj.org/article/a256dcb979ab4a63979d66feec6d2efc
Autor:
Tito Borner, Benjamin C. Reiner, Richard C. Crist, C. Daniel Furst, Sarah A. Doebley, Julia G. Halas, Minrong Ai, Ricardo J. Samms, Bart C. De Jonghe, Matthew R. Hayes
Publikováno v:
Molecular Metabolism, Vol 73, Iss , Pp 101743- (2023)
Objective: Nausea and vomiting remain life-threatening obstacles to successful treatment of chronic diseases, despite a cadre of available antiemetic medications. Our inability to effectively control chemotherapy-induced nausea and vomiting (CINV) hi
Externí odkaz:
https://doaj.org/article/1057d7b3ef0e41778c58fe147182cb30
Autor:
Benjamin C. Reiner, Yafang Zhang, Lauren M. Stein, Emilie Dávila Perea, Gabriella Arauco-Shapiro, Jennifer Ben Nathan, Kael Ragnini, Matthew R. Hayes, Thomas N. Ferraro, Wade H. Berrettini, Heath D. Schmidt, Richard C. Crist
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Opioid exposure is known to cause transcriptomic changes in the nucleus accumbens (NAc). However, no studies to date have investigated cell type-specific transcriptomic changes associated with volitional opioid taking. Here, we use single nu
Externí odkaz:
https://doaj.org/article/756b6ab2ac4045189079d2ea35baea58
Autor:
Uppala Radhakrishna, Swapan K. Nath, Lavanya V. Uppala, Avinash Veerappa, Ariadna Forray, Srinivas B. Muvvala, Raghu P. Metpally, Richard C. Crist, Wade H. Berrettini, Lori M. Mausi, Sangeetha Vishweswaraiah, Ray O. Bahado-Singh
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Introduction: The neonate exposed to opioids in utero faces a constellation of withdrawal symptoms postpartum commonly called neonatal opioid withdrawal syndrome (NOWS). The incidence of NOWS has increased in recent years due to the opioid epidemic.
Externí odkaz:
https://doaj.org/article/c43b82db4858456499c464d1dcf8d5a9
Autor:
Vanessa Troiani, Richard C. Crist, Glenn A. Doyle, Thomas N. Ferraro, Donielle Beiler, Stephanie Ranck, Kortney McBryan, Margaret A. Jarvis, Jordan S. Barbour, John J. Han, Ryan J. Ness, Wade H. Berrettini, Janet D. Robishaw
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021)
Abstract Background Prescription opioids (POs) are commonly used to treat moderate to severe chronic pain in the health system setting. Although they improve quality of life for many patients, more work is needed to identify both the clinical and gen
Externí odkaz:
https://doaj.org/article/aa29f8a7780448eb9cd5ffe46d15af0e
Autor:
Benjamin C. Reiner, Glenn A. Doyle, Andrew E. Weller, Rachel N. Levinson, Esin Namoglu, Alicia Pigeon, Emilie Dávila Perea, Cynthia Shannon Weickert, Gustavo Turecki, Deborah C. Mash, Richard C. Crist, Wade H. Berrettini
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 5, Pp 1647-1655 (2020)
Long interspersed element-1 retrotransposons (LINE-1 or L1) are ∼6 kb mobile DNA elements implicated in the origins of many Mendelian and complex diseases. The actively retrotransposing L1s are mostly limited to the L1 human specific (L1Hs) transcr
Externí odkaz:
https://doaj.org/article/b4f24c25c33048b8ad162a2ff355cb5b
Autor:
Benjamin C. Reiner, Richard C. Crist, Tito Borner, Robert P. Doyle, Matthew R. Hayes, Bart C. De Jonghe
Publikováno v:
Molecular Metabolism, Vol 56, Iss , Pp 101422- (2022)
Objective: Growth differentiation factor 15 (GDF15) is known to play a role in feeding, nausea, and body weight, with action through the GFRAL-RET receptor complex in the area postrema (AP) and nucleus tractus solitarius (NTS). To further elucidate t
Externí odkaz:
https://doaj.org/article/6f6cbabc2b6a49a58d1c61626c1bfb87
Autor:
Ray O Bahado-Singh, Sangeetha Vishweswaraiah, Buket Aydas, Ali Yilmaz, Raghu P Metpally, David J Carey, Richard C Crist, Wade H Berrettini, George D Wilson, Khalid Imam, Michael Maddens, Halil Bisgin, Stewart F Graham, Uppala Radhakrishna
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248375 (2021)
We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer's Disease (AD) detection and elucidates its molecular pathogeneses. Genome-wide DNA methylation analysis was performed using the Infinium MethylationEPIC BeadChip array in 24 l
Externí odkaz:
https://doaj.org/article/d9537ca420cb4d748465ee176c2f4948