Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Richard C Hresko"'
Autor:
Monique R Heitmeier, Richard C Hresko, Rachel L Edwards, Michael J Prinsen, Ma Xenia G Ilagan, Audrey R Odom John, Paul W Hruz
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216457 (2019)
Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule inhibitors have lacked promising drug-like structural features necessary for development as c
Externí odkaz:
https://doaj.org/article/5b482186f44d47e980b0f7cc11450eff
Autor:
Richard C Hresko, Paul W Hruz
Publikováno v:
PLoS ONE, Vol 6, Iss 9, p e25237 (2011)
The clinical use of several first generation HIV protease inhibitors (PIs) is associated with the development of insulin resistance. Indinavir has been shown to act as a potent reversible noncompetitive inhibitor of zero-trans glucose influx via dire
Externí odkaz:
https://doaj.org/article/bd4b1ea7324244afb0ae5d31247e75d3
Autor:
Shawna L. McMillin, Parker L. Evans, William M. Taylor, Luke A. Weyrauch, Tyler J. Sermersheim, Steven S. Welc, Monique R. Heitmeier, Richard C. Hresko, Paul W. Hruz, Francoise Koumanov, Geoffrey D. Holman, E. Dale Abel, Carol A. Witczak
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1734 (2022)
Glucose transporter 1 (GLUT1) is believed to solely mediate basal (insulin-independent) glucose uptake in skeletal muscle; yet recent work has demonstrated that mechanical overload, a model of resistance exercise training, increases muscle GLUT1 leve
Externí odkaz:
https://doaj.org/article/147a73ac6c2d4bab8a2344c5e3fe0de0
Autor:
Ma. Xenia G. Ilagan, Michael J. Prinsen, Richard C. Hresko, Audrey R. Odom John, Paul W. Hruz, Monique R. Heitmeier, Rachel L. Edwards
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0216457 (2019)
PLoS ONE, Vol 14, Iss 5, p e0216457 (2019)
Although the Plasmodium falciparum hexose transporter PfHT has emerged as a promising target for anti-malarial therapy, previously identified small-molecule inhibitors have lacked promising drug-like structural features necessary for development as c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ac9e2cf0e7dace19a9dc6fadeffbb9a
https://pubmed.ncbi.nlm.nih.gov/31071153
https://pubmed.ncbi.nlm.nih.gov/31071153
Publikováno v:
Protein Science. 24:2008-2019
The insulin-responsive facilitative glucose transporter GLUT4 is of fundamental importance for maintenance of glucose homeostasis. Despite intensive effort, the ability to express and purify sufficient quantities of structurally and functionally inta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea073ab092a5d72812aead5d10671f32
https://doi.org/10.1002/pro.2812
https://doi.org/10.1002/pro.2812
Autor:
Paul W. Hruz, Changyong Wei, Ajay K. Nooka, Mala Shanmugam, Richa Bajpai, Steven T. Rosen, Rama K. Mishra, Gary E. Schiltz, Richard C. Hresko, Shannon M. Matulis, Monique R. Heitmeier
Publikováno v:
Journal of Biological Chemistry. 290:14441-14453
Tumor cells rely on elevated glucose consumption and metabolism for survival and proliferation. Glucose transporters mediating glucose entry are key proximal rate-limiting checkpoints. Unlike GLUT1 that is highly expressed in cancer and more ubiquito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2449f608fd42969813998bbf9e2a728a
https://doi.org/10.1074/jbc.m114.628826
https://doi.org/10.1074/jbc.m114.628826
Publikováno v:
Journal of Biological Chemistry. 289:16100-16113
Pharmacologic HIV protease inhibitors (PIs) and structurally related oligopeptides are known to reversibly bind and inactivate the insulin-responsive facilitative glucose transporter 4 (GLUT4). Several PIs exhibit isoform selectivity with little effe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce92ad3a723e8904b3e0241b2864f461
https://doi.org/10.1074/jbc.m113.528430
https://doi.org/10.1074/jbc.m113.528430
Autor:
Mike Mueckler, Richard C. Hresko
Publikováno v:
Journal of Biological Chemistry. 280:40406-40416
The insulin-signaling pathway leading to the activation of Akt/protein kinase B has been well characterized except for a single step, the phosphorylation of Akt at Ser-473. Double-stranded DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a1fe5d071994da07ecaacaec1772022
https://doi.org/10.1074/jbc.m508361200
https://doi.org/10.1074/jbc.m508361200
Publikováno v:
Journal of Biological Chemistry. 278:21615-21622
By recombining subcellular components of 3T3-L1 adipocytes in a test tube, early insulin signaling events dependent on phosphatidylinositol 3-kinase (PI 3-kinase) were successfully reconstituted, up to and including the phosphorylation of glycogen sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df846011ef9387628f43a66561bb6a5
https://doi.org/10.1074/jbc.m302937200
https://doi.org/10.1074/jbc.m302937200
Publikováno v:
Journal of Biological Chemistry. 278:21607-21614
Early insulin signaling events were examined in a novel cell-free assay utilizing subcellular fractions derived from 3T3-L1 adipocytes. The following cellular processes were observed in vitro in a manner dependent on insulin, time of incubation, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6adba7b870636db3bc65c000a24286
https://doi.org/10.1074/jbc.m302934200
https://doi.org/10.1074/jbc.m302934200