Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Richard C Crist"'
Autor:
Ray O Bahado-Singh, Sangeetha Vishweswaraiah, Buket Aydas, Ali Yilmaz, Raghu P Metpally, David J Carey, Richard C Crist, Wade H Berrettini, George D Wilson, Khalid Imam, Michael Maddens, Halil Bisgin, Stewart F Graham, Uppala Radhakrishna
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0248375 (2021)
We evaluated the utility of leucocyte epigenomic-biomarkers for Alzheimer's Disease (AD) detection and elucidates its molecular pathogeneses. Genome-wide DNA methylation analysis was performed using the Infinium MethylationEPIC BeadChip array in 24 l
Externí odkaz:
https://doaj.org/article/d9537ca420cb4d748465ee176c2f4948
Autor:
Benjamin C. Reiner, Samar N. Chehimi, Riley Merkel, Sylvanus Toikumo, Wade H. Berrettini, Henry R. Kranzler, Sandra Sanchez-Roige, Rachel L. Kember, Heath D. Schmidt, Richard C. Crist
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Neural processing of rewarding stimuli involves several distinct regions, including the nucleus accumbens (NAc). The majority of NAc neurons are GABAergic projection neurons known as medium spiny neurons (MSNs). MSNs are broadly defined by d
Externí odkaz:
https://doaj.org/article/4327a3ae17324eff8169e5f06fa6237b
A conserved tissue-specific homeodomain-less isoform of MEIS1 is downregulated in colorectal cancer.
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23665 (2011)
Colorectal cancer is one of the most common cancers in developed nations and is the result of both environmental and genetic factors. Many of the genetic lesions observed in colorectal cancer alter expression of homeobox genes, which encode homeodoma
Externí odkaz:
https://doaj.org/article/803d086f7c76496393c5a2e63b1adc10
Autor:
Benjamin C. Reiner, Yafang Zhang, Lauren M. Stein, Emilie Dávila Perea, Gabriella Arauco-Shapiro, Jennifer Ben Nathan, Kael Ragnini, Matthew R. Hayes, Thomas N. Ferraro, Wade H. Berrettini, Heath D. Schmidt, Richard C. Crist
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Opioid exposure is known to cause transcriptomic changes in the nucleus accumbens (NAc). However, no studies to date have investigated cell type-specific transcriptomic changes associated with volitional opioid taking. Here, we use single nu
Externí odkaz:
https://doaj.org/article/756b6ab2ac4045189079d2ea35baea58
Autor:
Andrew E, Weller, Thomas N, Ferraro, Glenn A, Doyle, Benjamin C, Reiner, Richard C, Crist, Wade H, Berrettini
Publikováno v:
Journal of Alzheimer's Disease. 90:1233-1247
Background: 5XFAD humanized mutant mice and Trem2 knockout (T2KO) mice are two mouse models relevant to the study of Alzheimer’s disease (AD)-related pathology. Objective: To determine hippocampal transcriptomic and polyadenylation site usage alter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60ae39a122b3c3c9a8837429f05e0271
https://doi.org/10.3233/jad-220391
https://doi.org/10.3233/jad-220391
Autor:
Rachel L, Kember, Rachel, Vickers-Smith, Heng, Xu, Sylvanus, Toikumo, Maria, Niarchou, Hang, Zhou, Emily E, Hartwell, Richard C, Crist, Christopher T, Rentsch, Lea K, Davis, Amy C, Justice, Sandra, Sanchez-Roige, Kyle M, Kampman, Joel, Gelernter, Henry R, Kranzler
Publikováno v:
Nature Neuroscience. 25:1279-1287
Despite an estimated heritability of ~50%, genome-wide association studies of opioid use disorder (OUD) have revealed few genome-wide significant loci. We conducted a cross-ancestry meta-analysis of OUD in the Million Veteran Program (N = 425,944). I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62d79eba5b396e916764fb251c64205b
https://doi.org/10.1038/s41593-022-01160-z
https://doi.org/10.1038/s41593-022-01160-z
Autor:
Heng Xu, Sylvanus Toikumo, Richard C. Crist, Klaudia Glogowska, Zeal Jinwala, Joseph D. Deak, Amy C. Justice, Joel Gelernter, Emma C. Johnson, Henry R. Kranzler, Rachel L. Kember
Publikováno v:
Addiction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e92acc3820c0c2087ba897da7857aba
https://doi.org/10.1111/add.16229
https://doi.org/10.1111/add.16229
Autor:
Marcos J. Sanchez-Navarro, Tito Borner, Benjamin C. Reiner, Richard C. Crist, Willis K. Samson, Gina L. C. Yosten, Lauren Stein, Matthew R. Hayes
Publikováno v:
Nutrients; Volume 15; Issue 10; Pages: 2268
The g-protein coupled receptor GPR-160, recently identified as a putative receptor for the cocaine and amphetamine-regulated transcript (CART) peptide, shows abundant expression in the energy-balance control nuclei, including the dorsal vagal complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57dc948ada8484c3e7f8be1e4bfb45b
Autor:
Weili Ma, Maria Cecília Oliveira-Nunes, Ke Xu, Andrew Kossenkov, Benjamin C. Reiner, Richard C. Crist, James Hayden, Qing Chen
Publikováno v:
Nature Communications. 14
Cancer metastasis to the brain is a significant clinical problem. Metastasis is the consequence of favorable interactions between invaded cancer cells and the microenvironment. Here, we demonstrate that cancer-activated astrocytes create a sustained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::488096734db7923d41f2afdd44ea0658
https://doi.org/10.1038/s41467-023-38252-8
https://doi.org/10.1038/s41467-023-38252-8
Publikováno v:
Neurosci Res
A dataset of single-nucleus RNA sequencing (snRNAseq) data was analyzed using Seurat, Sierra, and Ingenuity Pathway Analysis (IPA) programs to assess differentially expressed genes (DEGs) and differential transcript usage (DTU) in mouse hippocampal c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4eadb6e01dce2ae4509aed21482f3d
https://doi.org/10.1016/j.neures.2021.10.010
https://doi.org/10.1016/j.neures.2021.10.010