Zobrazeno 1 - 10
of 146
pro vyhledávání: '"Richard C, Hartley"'
Autor:
Jan Lj. Miljkovic, Nils Burger, Justyna M. Gawel, John F. Mulvey, Abigail A.I. Norman, Takanori Nishimura, Yoshiyuki Tsujihata, Angela Logan, Olga Sauchanka, Stuart T. Caldwell, Jordan L. Morris, Tracy A. Prime, Stefan Warrington, Julien Prudent, Georgina R. Bates, Dunja Aksentijević, Hiran A. Prag, Andrew M. James, Thomas Krieg, Richard C. Hartley, Michael P. Murphy
Publikováno v:
Redox Biology, Vol 55, Iss , Pp 102429- (2022)
Mitochondria-targeted H2S donors are thought to protect against acute ischemia-reperfusion (IR) injury by releasing H2S that decreases oxidative damage. However, the rate of H2S release by current donors is too slow to be effective upon administratio
Externí odkaz:
https://doaj.org/article/f01616a12f704ac39a2ca4515711e427
Autor:
Dylan G. Ryan, Elena V. Knatko, Alva M. Casey, Jens L. Hukelmann, Sharadha Dayalan Naidu, Alejandro J. Brenes, Thanapon Ekkunagul, Christa Baker, Maureen Higgins, Laura Tronci, Efterpi Nikitopolou, Tadashi Honda, Richard C. Hartley, Luke A.J. O’Neill, Christian Frezza, Angus I. Lamond, Andrey Y. Abramov, J. Simon C. Arthur, Doreen A. Cantrell, Michael P. Murphy, Albena T. Dinkova-Kostova
Publikováno v:
iScience, Vol 25, Iss 2, Pp 103827- (2022)
Summary: To overcome oxidative, inflammatory, and metabolic stress, cells have evolved cytoprotective protein networks controlled by nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) and its negative regulator, Kelch-like ECH associated protein
Externí odkaz:
https://doaj.org/article/59b0d8bd2ed646e68bc099da31cf94d0
Autor:
Timothy E. Beach, Hiran A. Prag, Laura Pala, Angela Logan, Margaret M. Huang, Anja V. Gruszczyk, Jack L. Martin, Krishnaa Mahbubani, Mazin O. Hamed, Sarah A. Hosgood, Michael L. Nicholson, Andrew M. James, Richard C. Hartley, Michael P. Murphy, Kourosh Saeb-Parsy
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101640- (2020)
Renal ischemia reperfusion (IR) injury leads to significant patient morbidity and mortality, and its amelioration is an urgent unmet clinical need. Succinate accumulates during ischemia and its oxidation by the mitochondrial enzyme succinate dehydrog
Externí odkaz:
https://doaj.org/article/038ddcdac34144049d5f8e694c7a30c8
Autor:
Anindya Roy Chowdhury, Jacek Zielonka, Balaraman Kalyanaraman, Richard C. Hartley, Michael P. Murphy, Narayan G. Avadhani
Publikováno v:
Redox Biology, Vol 36, Iss , Pp 101606- (2020)
The mitochondrial electron transport chain is a major source of reactive oxygen species (ROS) and is also a target of ROS, with an implied role in the stabilization of hypoxia-inducible factor (HIF) and induction of the AMPK pathway. Here we used var
Externí odkaz:
https://doaj.org/article/58c1fa1d4a5f46729fb31d06fda46e76
Autor:
Laura Pala, Hans M. Senn, Stuart T. Caldwell, Tracy A. Prime, Stefan Warrington, Thomas P. Bright, Hiran A. Prag, Claire Wilson, Michael P. Murphy, Richard C. Hartley
Publikováno v:
Frontiers in Chemistry, Vol 8 (2020)
There is considerable interest in developing drugs and probes targeted to mitochondria in order to understand and treat the many pathologies associated with mitochondrial dysfunction. The large membrane potential, negative inside, across the mitochon
Externí odkaz:
https://doaj.org/article/55f3b6d8361e43d484624302dfb0660e
Autor:
Shinpei Uno, Alexander H. Harkiss, Roy Chowdhury, Stuart T. Caldwell, Tracy A. Prime, Andrew M. James, Brendan Gallagher, Julien Prudent, Richard C. Hartley, Michael P. Murphy
The targeting of bioactive molecules and probes to mitochondria can be achieved by coupling to the lipophilic triphenyl phosphonium (TPP) cation, which accumulates several hundred-fold within mitochondria in response to the mitochondrial membrane pot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95a5af6fe0fa731cdfc5050043de79d
https://www.repository.cam.ac.uk/handle/1810/349471
https://www.repository.cam.ac.uk/handle/1810/349471
Autor:
Gigi Y. Lau, Nicholas Barts, Richard C. Hartley, Michael Tobler, Jeffrey G. Richards, Michael P. Murphy, Sabine Arndt
Publikováno v:
Biology Open, Vol 8, Iss 5 (2019)
In this paper, we outline the use of a mitochondria-targeted ratiometric mass spectrometry probe, MitoA, to detect in vivo changes in mitochondrial hydrogen sulfide (H2S) in Poecilia mexicana (family Poeciliidae). MitoA is introduced via intraperiton
Externí odkaz:
https://doaj.org/article/d223cd4af0fa4455a7843401bdbe4df3
Autor:
Andrea Pawellek, Ursula Ryder, Triin Tammsalu, Lewis J King, Helmi Kreinin, Tony Ly, Ronald T Hay, Richard C Hartley, Angus I Lamond
Publikováno v:
eLife, Vol 6 (2017)
We have identified the plant biflavonoid hinokiflavone as an inhibitor of splicing in vitro and modulator of alternative splicing in cells. Chemical synthesis confirms hinokiflavone is the active molecule. Hinokiflavone inhibits splicing in vitro by
Externí odkaz:
https://doaj.org/article/5511bcb97c1940439d260bcc3a89f1d7
Autor:
Andrew M. James, Abigail A.I. Norman, Jack W. Houghton, Hiran A. Prag, Angela Logan, Robin Antrobus, Richard C. Hartley, Michael P. Murphy
During metabolism, carboxylic acids are often activated by conjugation to the thiol of coenzyme A (CoA). The resulting acyl-CoAs comprise a group of ∼100 thioester-containing metabolites that could modify protein behavior through non-enzymatic N-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34b911aa9580d8fe83e90a375365cc5c
https://www.repository.cam.ac.uk/handle/1810/336351
https://www.repository.cam.ac.uk/handle/1810/336351
Autor:
Misbah Hussain, ZhiGuo Zou, Francisco J. Rios, Fazli Rabbi Awan, Yu Wang, Augusto C. Montezano, Rhian M. Touyz, Thomas Jensen, Rheure Alves-Lopes, Tomasz J. Guzik, Richard C. Hartley, Karla B Neves, Livia L Camargo
AIMS NOX-derived reactive oxygen species (ROS) are mediators of signaling pathways implicated in vascular smooth muscle cell (VSMC) dysfunction in hypertension. Among the numerous redox-sensitive kinases important in VSMC regulation is c-Src. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070be2b6c3a93d7c45920c5d3ad85bf8
https://ruj.uj.edu.pl/xmlui/handle/item/290254
https://ruj.uj.edu.pl/xmlui/handle/item/290254