Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Richard Barido"'
Autor:
Susan McQuown, Shouzhen Xia, Karsten Baumgärtel, Richard Barido, Gary Anderson, Brian Dyck, Roderick Scott, Marco Peters
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Augmentation of cyclic nucleotide signaling through inhibition of phosphodiesterase (PDE) activity has long been understood to enhance memory. Efforts in this domain have focused predominantly on PDE4, a cAMP-specific phosphodiesterase implicated in
Externí odkaz:
https://doaj.org/article/cb32a278a3ec4df0b94cb3e803e7beb1
Autor:
Kiev S. Ly, Andrew Richard Hudson, Christine Hoffmaster, James T. Limberis, J. Guy Breitenbucher, Richard Barido, De Michael Chung, Yingzhuo Yan, Gary Anderson, Vincent J. Santora, Dany Gitnick, Dong Lee, Brett C. Bookser, Anne Danks, Robert E. Petroski, Graeme Freestone, Varsha Gupta, Clifford Cabebe, Andrew Morse, Michael R. Kennedy, Kristen Sebring, Zachary W. Yoder, Douglas Zook, Marco Peters, Chih-Kun Chai, Joel Renick, Jim Na, Theresa A. Almos, Shouzhen Xia, Ali Tabatabaei, John Nikpur, Samantha Sevidal, Stephine Chow, Mi Chen, Jillian Basinger, Chris L. Bellows, Lindsay Heger, David Neul, Jenny Wen, Brittany Masatsugu, Nicola J. Broadbent, Alan P. Kaplan, Chi Ching Mak
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(14)
A strategy to conformationally restrain a series of GlyT1 inhibitors identified potent analogs that exhibited slowly interconverting rotational isomers. Further studies to address this concern led to a series of azetidine-based inhibitors. Compound 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::912579fcc2f963bd82182bdd275301b0
https://pubmed.ncbi.nlm.nih.gov/32527538
https://pubmed.ncbi.nlm.nih.gov/32527538
Autor:
David Neul, Andrew Morse, Joel Renick, Brittany Masatsugu, Chi Ching Mak, James T. Limberis, Dany Gitnick, Zachary W. Yoder, Michael R. Kennedy, Kiev S. Ly, Samantha Sevidal, Richard Barido, Robert E. Petroski, Graeme Freestone, Clifford Cabebe, Jillian Basinger, Vincent J. Santora, Christine Hoffmaster, Chris L. Bellows, Yingzhuo Yan, Mi Chen, De Michael Chung, John Nikpur, Kristen Sebring, Jenny Wen, Ali Tabatabaei, Brett C. Bookser, Theresa A. Almos, Andrew Richard Hudson, J. Guy Breitenbucher, Chih-Kun Chai, Dong Lee, Lindsay Crickard, Anne Danks, Varsha Gupta, Marco Peters, Alan P. Kaplan, Jim Na, Nicola J. Broadbent, Stephine Chow, Douglas Zook
Publikováno v:
Journal of Medicinal Chemistry. 61:6018-6033
We report here the identification and optimization of a novel series of potent GlyT1 inhibitors. A ligand design campaign that utilized known GlyT1 inhibitors as starting points led to the identification of a novel series of pyrrolo[3,4- c]pyrazoles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3769bd94e72c5343ca6a4bb3a9739f64
https://doi.org/10.1021/acs.jmedchem.8b00372
https://doi.org/10.1021/acs.jmedchem.8b00372
Autor:
Karsten Baumgärtel, Richard Barido, Marco Peters, Susan McQuown, Roderick E.M. Scott, Gary Anderson, Shouzhen Xia, Brian Dyck
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
Augmentation of cyclic nucleotide signaling through inhibition of phosphodiesterase (PDE) activity has long been understood to enhance memory. Efforts in this domain have focused predominantly on PDE4, a cAMP-specific phosphodiesterase implicated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::671b01ee48625bb0a7117a48d3593fc7
https://www.frontiersin.org/article/10.3389/fnmol.2019.00021/full
https://www.frontiersin.org/article/10.3389/fnmol.2019.00021/full
Autor:
Margaret McCarrick, Richard Barido, Troy Vickers, Ali Tabatabaei, J. Guy Breitenbucher, Mark Eben Massari, Robert Lemus, Laurent Gomez, Marco Peters, Markus Metz, Rui Xu, Xianbo Zhou, David Neul, William F. Vernier, Nicola J. Broadbent, Yingzhou G. Yan, Graeme Freestone, Kathleen Aertgeerts, Zachary W. Yoder, Noelle Warren, Carsten B. Andersen, Kara Schmelzer, Kristen Sebring, Kiev S. Ly, Tami Jo Marrone, Dong Lee
Publikováno v:
Journal of medicinal chemistry. 60(5)
A series of potent and selective [1,2,4]triazolo[1,5-a]pyrimidine PDE2a inhibitors is reported. The design and improvement of the binding properties of this series was achieved using X-ray crystal structures in conjunction with careful analysis of el
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1182b754c4dd43b3c46f5466d100d5
https://pubmed.ncbi.nlm.nih.gov/28165743
https://pubmed.ncbi.nlm.nih.gov/28165743
Publikováno v:
43rd International Conference on Environmental Systems.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ddde9c6ec3d3274f1e7a03a85517982
https://doi.org/10.2514/6.2013-3493
https://doi.org/10.2514/6.2013-3493
Publikováno v:
42nd International Conference on Environmental Systems.
The Orion Multi Purpose Crew Vehicle (MPCV) is the first crew transport vehicle to be developed by the National Aeronautics and Space Administration (NASA) in the last thirty years. Orion is currently being developed to transport the crew safely from
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc53c78316f7338cae429a32db1380cf
https://doi.org/10.2514/6.2012-3531
https://doi.org/10.2514/6.2012-3531
Publikováno v:
41st International Conference on Environmental Systems.
Computational fluid dynamics (CFD) is used to model the flow field in the Orion crew exploration vehicle (CEV) cabin. The CFD model employs a momentum model used to account for the effect of supply grilles on the supply flow. This model is modified t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9de09bfd69fec018e5b3d0e57459a3a0
https://doi.org/10.2514/6.2011-5077
https://doi.org/10.2514/6.2011-5077
Publikováno v:
41st International Conference on Environmental Systems.
Recent changes in the overall NASA vision has resulted in further cost and schedule challenges for the Orion program. As a result, additional scrutiny has been focused on the use of new developments for hardware in the environmental control and life
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efdc49e0cf2f0601b00b0c076bbb4f12
https://doi.org/10.2514/6.2011-5082
https://doi.org/10.2514/6.2011-5082
Publikováno v:
41st International Conference on Environmental Systems.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a517792eb00661e3375395306fa1bcf0
https://doi.org/10.2514/6.2011-5084
https://doi.org/10.2514/6.2011-5084