Zobrazeno 1 - 10 of 59 pro vyhledávání: '"Richard B. Sykes"'
1
Taking risks with translational research
Autor: Ian G. Mills, Richard B. Sykes
Publikováno v: Science translational medicine. 2(24)
The recent bankruptcy fi ling by deCODE, a company with an exceptional pedigree in asso- ciating genetic variance with disease onset, highlights the commercial risks of translational research. Indeed, deCODE's approach was similar to that adapted by
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b033330593ddbfbb506771394100c30a
https://pubmed.ncbi.nlm.nih.gov/20424010
Zobrazit plný text záznamu
4
NOVEL POTENTIATORS OF β-LACTAM ANTIBIOTICS
Autor: J. Scott Wells, Richard B. Sykes, Raymond Cooper
Publikováno v: The Journal of Antibiotics. 38:449-454
Two novel compounds, SQ28, 504 and SQ28, 546 are produced by Chromobacterium violaceum. These compounds enhance the antibacterial activity of β-lactam antibiotics against Gram-negative organisms. Both SQ28, 504 and SQ28, 546 induce morphological cha
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::61e90453c0a314f55558c56f35708b5c
https://doi.org/10.7164/antibiotics.38.449
Zobrazit plný text záznamu
6
Mode of action of azthreonam
Autor: Richard B. Sykes, N H Georgopapadakou, S A Smith
Publikováno v: Antimicrobial Agents and Chemotherapy. 21:950-956
Azthreonam (SQ 26,776) is a member of a new class of monocyclic beta-lactam antibiotics. In Escherichia coli, azthreonam caused filamentation at its lowest effective concentration (0.2 microgram/ml), a morphological effect identical to that observed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8cf4702335ba4546bea5bdbde26834
https://doi.org/10.1128/aac.21.6.950
Zobrazit plný text záznamu
7
SQ 26,180, a novel monobactam. I. Taxonomy, fermentation and biological properties
Autor: J S Wells, Karen Bush, Pacifico A. Principe, D. P. Bonner, Richard B. Sykes, N H Georgopapadakou, William H. Trejo
Publikováno v: The Journal of Antibiotics. 35:184-188
Strains of Chromobacterium violaceum, isolated from various environments, were found to produce a novel monocyclic beta-lactam antibiotic. The antibiotic, SQ 26,180 was weakly active against Gram-positive and Gram-negative bacteria with the exception
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0f56f7ad5905233b7daf2a1a54c9b2b
https://doi.org/10.7164/antibiotics.35.184
Zobrazit plný text záznamu
8
Izumenolide - a novel .BETA.-lactamase inhibitor produced by Micromonospora. II. Biological properties
Autor: Richard B. Sykes, Karen Bush, Daniel P. Bonner
Publikováno v: The Journal of Antibiotics. 33:1262-1269
Izumenolide is a potent inhibitor of beta-lactamases, especially from Gram-negative bacteria. The I50 value of 0.01 microgram/ml for TEM-2 beta-lactamase, after 10 min preincubation, corresponds to a ratio of 7.6 moles inhibitor per mole of enzyme. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dd140b34e387dbd649cd00dbd8ddad6
https://doi.org/10.7164/antibiotics.33.1262
Zobrazit plný text záznamu
9
Discovery and Development of the Monobactams
Autor: D. P. Bonner, Richard B. Sykes
Publikováno v: Clinical Infectious Diseases. 7:S579-S593
A novel procedure designed to detect naturally occurring beta-lactam-containing molecules led to isolation of the monobactams - structurally unique, bacterially produced, monocyclic beta-lactam antibiotics. Although none of these monobactams exhibite
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c204b62568dc47d157fe6697e0e12a27
https://doi.org/10.1093/clinids/7.supplement_4.s579
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje