Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Richard B. Sessions"'
Autor:
Shisanupong Anukanon, Pornkanok Pongpamorn, Wareepat Tiyabhorn, Jaruwan Chatwichien, Worawat Niwetmarin, Richard B. Sessions, Somsak Ruchirawat, Nopporn Thasana
Publikováno v:
ACS Omega, Vol 6, Iss 30, Pp 19924-19939 (2021)
Externí odkaz:
https://doaj.org/article/cd111d082ca9489e915ed924a711eedb
Autor:
Gaelle R. Carrat, Elizabeth Haythorne, Alejandra Tomas, Leena Haataja, Andreas Müller, Peter Arvan, Alexandra Piunti, Kaiying Cheng, Mutian Huang, Timothy J. Pullen, Eleni Georgiadou, Theodoros Stylianides, Nur Shabrina Amirruddin, Victoria Salem, Walter Distaso, Andrew Cakebread, Kate J. Heesom, Philip A. Lewis, David J. Hodson, Linford J. Briant, Annie C.H. Fung, Richard B. Sessions, Fabien Alpy, Alice P.S. Kong, Peter I. Benke, Federico Torta, Adrian Kee Keong Teo, Isabelle Leclerc, Michele Solimena, Dale B. Wigley, Guy A. Rutter
Publikováno v:
Molecular Metabolism, Vol 40, Iss , Pp 101015- (2020)
Objective: Risk alleles for type 2 diabetes at the STARD10 locus are associated with lowered STARD10 expression in the β-cell, impaired glucose-induced insulin secretion, and decreased circulating proinsulin:insulin ratios. Although likely to serve
Externí odkaz:
https://doaj.org/article/075506f07a044c31be2e44b42ccc2527
Autor:
Aysha B. Mezoughi, Chiara M. Costanzo, Gregor M. Parker, Enas M. Behiry, Alan Scott, Andrew C. Wood, Sarah E. Adams, Richard B. Sessions, E. Joel Loveridge
Publikováno v:
Molecules, Vol 26, Iss 14, p 4189 (2021)
Lytic transglycosylases such as Slt35 from E. coli are enzymes involved in bacterial cell wall remodelling and recycling, which represent potential targets for novel antibacterial agents. Here, we investigated a series of known glycosidase inhibitors
Externí odkaz:
https://doaj.org/article/84b975e7244748d283e024c32655050f
Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme
Autor:
Daniel W. Watkins, Jonathan M. X. Jenkins, Katie J. Grayson, Nicola Wood, Jack W. Steventon, Kristian K. Le Vay, Matthew I. Goodwin, Anna S. Mullen, Henry J. Bailey, Matthew P. Crump, Fraser MacMillan, Adrian J. Mulholland, Gus Cameron, Richard B. Sessions, Stephen Mann, J. L. Ross Anderson
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Catalytic mechanisms of enzymes are well understood, but achieving diverse reaction chemistries in re-engineered proteins can be difficult. Here the authors show a highly efficient and thermostable artificial enzyme that catalyzes a diverse array of
Externí odkaz:
https://doaj.org/article/872155373e0341fa822353dc3be89d1d
Autor:
Gülşah P. Özgün, Emel B. Ordu, H. Esra Tütüncü, Emrah Yelboğa, Richard B. Sessions, Nevin Gül Karagüler
Publikováno v:
Scientifica, Vol 2016 (2016)
In NADH regeneration, Candida methylica formate dehydrogenase (cmFDH) is a highly significant enzyme in pharmaceutical industry. In this work, site saturation mutagenesis (SSM) which is a combination of both rational design and directed evolution app
Externí odkaz:
https://doaj.org/article/d26753eb03f34a189291509ebb61c5b7
Autor:
Natalia Jiménez-Moreno, Madhu Kollareddy, Petros Stathakos, Joanna J. Moss, Zuriñe Antón, Deborah K. Shoemark, Richard B. Sessions, Ralph Witzgall, Maeve Caldwell, Jon D. Lane
Publikováno v:
Journal of Cell Biology. 222
The LIM homeodomain transcription factors LMX1A and LMX1B are essential mediators of midbrain dopaminergic neuronal (mDAN) differentiation and survival. Here we show that LMX1A and LMX1B are autophagy transcription factors that provide cellular stres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef66e2f4239e8c0ea1f02d78333eb496
https://doi.org/10.1083/jcb.201910133
https://doi.org/10.1083/jcb.201910133
Autor:
Nopporn Thasana, Shisanupong Anukanon, Jaruwan Chatwichien, Wareepat Tiyabhorn, Somsak Ruchirawat, Worawat Niwetmarin, Pornkanok Pongpamorn, Richard B. Sessions
Publikováno v:
ACS Omega
Anukanon, S, Pongpamorn, P, Tiyabhorn, W, Chatwichien, J, Niwetmarin, W, Sessions, R B, Ruchirawat, S & Thasana, N 2021, ' In Silico-Guided Rational Drug Design and Semi-synthesis of C(2)-Functionalized Huperzine A Derivatives as Acetylcholinesterase Inhibitors ', ACS Omega, vol. 6, no. 30, pp. 19924-19939 . https://doi.org/10.1021/acsomega.1c02875
ACS Omega, Vol 6, Iss 30, Pp 19924-19939 (2021)
Anukanon, S, Pongpamorn, P, Tiyabhorn, W, Chatwichien, J, Niwetmarin, W, Sessions, R B, Ruchirawat, S & Thasana, N 2021, ' In Silico-Guided Rational Drug Design and Semi-synthesis of C(2)-Functionalized Huperzine A Derivatives as Acetylcholinesterase Inhibitors ', ACS Omega, vol. 6, no. 30, pp. 19924-19939 . https://doi.org/10.1021/acsomega.1c02875
ACS Omega, Vol 6, Iss 30, Pp 19924-19939 (2021)
Huperzine A (1, Hup A), a lycodine-type Lycopodium alkaloid isolated from Thai clubmosses Huperzia squarrosa (G. Forst.) Trevis., H. carinata (Desv. ex. Poir.) Trevis., H. phlegmaria (L.), and Phlegmariurus nummulariifolius (Blume) Chambers (Lycopodi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ccb07ef5be53320fa6f4cf8512820b
http://europepmc.org/articles/PMC8340427
http://europepmc.org/articles/PMC8340427
Autor:
Lara S R Small, Martin J Zuckermann, Richard B Sessions, Paul M G Curmi, Heiner Linke, Nancy R Forde, Elizabeth H C Bromley
Publikováno v:
New Journal of Physics, Vol 21, Iss 1, p 013002 (2019)
One challenge to synthetic biology is to design functional machines from natural building blocks, from individual amino acids up to larger motifs such as the coiled coil. Here we investigate a novel bipedal motor concept, the Bar-Hinge Motor (BHM), a
Externí odkaz:
https://doaj.org/article/ed67dbce2f2e42579e01d8972d0d8b50
Autor:
Timothy Gallagher, Cecilia Gotti, Ana Sofia F Oliveira, Beatriz Elizabeth Nielsen, Richard B. Sessions, Isabel Bermudez, Adrian J. Mulholland, Teresa Minguez-Viñas, Cecilia Bouzat, Deborah K. Shoemark, Susan Wonnacott
Publikováno v:
Minguez-Viñas, T, Nielsen, B E, Shoemark, D K, Gotti, C, Sessions, R B, Mulholland, A J, Bouzat, C, Wonnacott, S, Gallagher, T, Bermudez, I & Oliveira, A S 2021, ' A conserved arginine with non-conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors ', British Journal of Pharmacology, vol. 178, no. 7, pp. 1651-1668 . https://doi.org/10.1111/bph.15389
Minguez Viñas, T, Shoemark, D K, Sessions, R B, Mulholland, A J, Gallagher, T, Oliveira, A S & al., E 2021, ' A conserved arginine with non-conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors ', British Journal of Pharmacology, vol. 178, no. 7, pp. 1651-1668 . https://doi.org/10.1111/bph.15389
Minguez Viñas, T, Shoemark, D K, Sessions, R B, Mulholland, A J, Gallagher, T, Oliveira, A S & al., E 2021, ' A conserved arginine with non-conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors ', British Journal of Pharmacology, vol. 178, no. 7, pp. 1651-1668 . https://doi.org/10.1111/bph.15389
Background and PurposeThe α7 and α4β2* (“*” denotes possibly assembly with another subunit) nicotinic acetylcholine receptors (nAChRs) are the most abundant nAChRs in the mammalian brain. These receptors are the most targeted nAChRs in drug di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49465823bbfc1af3116cfe62a1b97773
https://doi.org/10.1111/bph.15389
https://doi.org/10.1111/bph.15389
Publikováno v:
Elseginy, S A, Oliveira, S, Shoemark, D K & Sessions, R B 2022, ' Identification and validation of novel microtubule suppressors with an imidazopyridine scaffold through structure-based virtual screening and docking ', RSC medicinal chemistry, vol. 13, no. 8, pp. 929-943 . https://doi.org/10.1039/D1MD00392E
Targeting the colchicine binding site of α/β tubulin microtubules can lead to suppression of microtubule dynamics, cell cycle arrest and apoptosis. Therefore, the development of microtubule (MT) inhibitors is considered a promising route to antican
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548d2e2b29d45180b670ba1a6be51b5c
https://research-information.bris.ac.uk/ws/files/333784347/d1md00392e.pdf
https://research-information.bris.ac.uk/ws/files/333784347/d1md00392e.pdf
