Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Richard B. Pouw"'
Autor:
Anna E. van Beek, Hannah Jeanguenat, Cécile Häberli, Richard B. Pouw, Christina Lamers, Gábor Pál, Péter Gál, Christoph Q. Schmidt, Daniel Ricklin, Jennifer Keiser
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundSchistosomes are highly efficient evaders of human immunity, as evident by their ability to survive in human blood for years. How they protect themselves against the constant attack by a key element of innate immunity, the complement system
Externí odkaz:
https://doaj.org/article/57c8f723b6b34a32a74928707eb54f8b
Autor:
Murielle Golomingi, Jessie Kohler, Christina Lamers, Richard B. Pouw, Daniel Ricklin, József Dobó, Péter Gál, Gábor Pál, Bence Kiss, Arthur Dopler, Christoph Q. Schmidt, Elaissa Trybus Hardy, Wilbur Lam, Verena Schroeder
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundHaemostasis is a crucial process by which the body stops bleeding. It is achieved by the formation of a platelet plug, which is strengthened by formation of a fibrin mesh mediated by the coagulation cascade. In proinflammatory and prothromb
Externí odkaz:
https://doaj.org/article/6f75ad8a067c46fa8645d29059b9d3be
Autor:
Anna E. van Beek, Richard B. Pouw, Victoria J. Wright, Neneh Sallah, David Inwald, Clive Hoggart, Mieke C. Brouwer, Rachel Galassini, John Thomas, Leo Calvo-Bado, Colin G. Fink, Ilse Jongerius, Martin Hibberd, Diana Wouters, Michael Levin, Taco W. Kuijpers
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Neisseria meningitidis, the causative agent of meningococcal disease (MD), evades complement-mediated clearance upon infection by ‘hijacking’ the human complement regulator factor H (FH). The FH protein family also comprises the homologous FH-rel
Externí odkaz:
https://doaj.org/article/53ed33bca7f341b9841c1738794a9112
Autor:
E. Soemirien Kasanmoentalib, Mercedes Valls Serón, Joo Yeon Engelen-Lee, Michael W. Tanck, Richard B. Pouw, Gerard van Mierlo, Diana Wouters, Matthew C. Pickering, Arie van der Ende, Taco W. Kuijpers, Matthijs C. Brouwer, Diederik van de Beek
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)
Abstract Background The complement system is a vital component of the inflammatory response occurring during bacterial meningitis. Blocking the complement system was shown to improve the outcome of experimental pneumococcal meningitis. Complement fac
Externí odkaz:
https://doaj.org/article/709758e90fc34fbda773f3104d709fc5
Autor:
Richard B. Pouw, Irene Gómez Delgado, Alberto López Lera, Santiago Rodríguez de Córdoba, Diana Wouters, Taco W. Kuijpers, Pilar Sánchez-Corral
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Externí odkaz:
https://doaj.org/article/ff78a7793bee449384e22493cbb00574
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The alternative pathway is a continuously active surveillance arm of the complement system, and it can also enhance complement activation initiated by the classical and the lectin pathways. Various membrane-bound and plasma regulatory proteins contro
Externí odkaz:
https://doaj.org/article/e0c351b4103f44a1b729463eacb1031e
Autor:
Richard B. Pouw, Irene Gómez Delgado, Alberto López Lera, Santiago Rodríguez de Córdoba, Diana Wouters, Taco W. Kuijpers, Pilar Sánchez-Corral
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Dysregulation of the complement alternative pathway (AP) is a major pathogenic mechanism in atypical hemolytic-uremic syndrome (aHUS). Genetic or acquired defects in factor H (FH), the main AP regulator, are major aHUS drivers that associate with a p
Externí odkaz:
https://doaj.org/article/fee3d5ffa6bf4ec29c11e2e76bc41997
Autor:
Richard B. Pouw, Mieke C. Brouwer, Anna E. van Beek, Mihály Józsi, Diana Wouters, Taco W. Kuijpers
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Recent research has elucidated circulating levels of almost all factor H-related (FHR) proteins. Some of these proteins are hypothesized to act as antagonists of the important complement regulator factor H (FH), fine-tuning complement regulation on h
Externí odkaz:
https://doaj.org/article/766b4f5dac5846798d91a18943a4fcb9
Autor:
Anna E. van Beek, Richard B. Pouw, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Pleuni Ooijevaar-de Heer, Martin de Boer, Karin van Leeuwen, Theo Rispens, Diana Wouters, Taco W. Kuijpers
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
The complement factor H-related (FHR) proteins are hypothesized to fine-tune the regulatory role of complement factor H (FH) in the alternative pathway of the complement system. Moreover, FHR-1, FHR-2, and FHR-5 have been proposed to be dimers, which
Externí odkaz:
https://doaj.org/article/fb471257e25b469cb0328c252b127083
Autor:
Nicole Schäfer, Antje Grosche, Joerg Reinders, Stefanie Hauck, Richard B. Pouw, Taco W. Kuijpers, Diana Wouters, Boris Ehrenstein, Volker Enzmann, Peter Zipfel, Christine Skerka, Diana Pauly
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
The human complement factor H-related protein-3 (FHR-3) is a soluble regulator of the complement system. Homozygous cfhr3/1 deletion is a genetic risk factor for the autoimmune form of hemolytic uremic syndrome (aHUS), whilst also found to be protect
Externí odkaz:
https://doaj.org/article/aca3d5f5edaa4e228d242b2ec4b43654