Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Richard B. Mortensen"'
Publikováno v:
Methods. 167:92-104
Second-harmonic generation (SHG) is a biophysical tool that senses ligand-induced conformational changes in biomolecules. The Biodesy Delta™ has been developed as a high-throughput screening platform to monitor conformational changes in proteins an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f224ff892a0781608c478f4068db59d6
https://doi.org/10.1016/j.ymeth.2019.05.012
https://doi.org/10.1016/j.ymeth.2019.05.012
Publikováno v:
Analytical chemistry. 88(21)
There is a high demand for characterizing oligonucleotide structural changes associated with binding interactions as well as identifying novel binders that modulate their structure and function. In this study, second-harmonic generation (SHG) was use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f112677942f2aac68207a0c61271362
https://pubmed.ncbi.nlm.nih.gov/27696827
https://pubmed.ncbi.nlm.nih.gov/27696827
Autor:
Jérémy Saugy, Sylvain Giraud, Peter J. Schatz, Nicolas Leuenberger, Martial Saugy, Richard B. Mortensen
Publikováno v:
Forensic Science International. 213:15-19
Since the 1990's, cheating athletes have abused substances to increase their oxygen transport capabilities; among these substances, recombinant EPO is the most well known. Currently, other investigational pharmaceutical products are able to produce a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a10037b97265647e94beeeaaf10827cc
https://doi.org/10.1016/j.forsciint.2011.07.012
https://doi.org/10.1016/j.forsciint.2011.07.012
Autor:
Nicole Casadevall, Qing Fan, Kathryn W. Woodburn, Chen Min-Jia, Susan Winslow, Richard B. Mortensen, Peter J. Schatz, Richard B. Stead
Publikováno v:
Experimental Hematology. 35:1201-1208
Objective To evaluate the potential of Hematide, a PEGylated, synthetic peptide–based erythropoiesis-stimulating agent that is in clinical development for the treatment of anemia associated with chronic kidney disease and cancer, to correct antiery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80337bb00741c15b6a880cfe5e607274
https://doi.org/10.1016/j.exphem.2007.05.007
https://doi.org/10.1016/j.exphem.2007.05.007
Publikováno v:
Analytical Biochemistry. 273:20-31
We have developed a novel fluorescence-based homogeneous binding assay for high-throughput screening of chemical compounds. In this assay, a Cy5- or Cy5.5-labeled ligand binds to receptor immobilized on a particle, either a bead or a cell. The result
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6838a965a6cfe132e8494afc9bc02f0e
https://doi.org/10.1006/abio.1999.4184
https://doi.org/10.1006/abio.1999.4184
Autor:
Ronald W. Barrett, Lynn Kochersperger, Emily Tate, Stephen Yanofsky, Erik A. Whitehorn, Kim Bell, William J. Dower, Richard B. Mortensen, Ann Davis, Shirlee Yonkovich
Publikováno v:
Nature Biotechnology. 13:1215-1219
A general method for expression, purification, immobilization, detection and radiolabeling of extracellular domains (ECD) of type I membrane proteins. The type I interleukin-1 receptor (IL-1RtI), the alpha-subunit of interleukin-2 receptor (IL-2R alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2bafce1359441c78639dee58571076c
https://doi.org/10.1038/nbt1195-1215
https://doi.org/10.1038/nbt1195-1215
Autor:
Don M. Wojchowski, Richard B. Mortensen, Peter J. Schatz, Angela Worth, Karen Leu, David K. Martinez, Peter R. Young, Jennifer M. Green
Peginesatide is a synthetic, PEGylated, peptide-based erythropoiesis-stimulating agent that is designed and engineered to stimulate specifically the erythropoietin receptor dimer that governs erythropoiesis. Peginesatide has a unique structure that c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a020084463920cdd4e337c342a520228
https://europepmc.org/articles/PMC3985406/
https://europepmc.org/articles/PMC3985406/
Autor:
Don M. Wojchowski, Angela Worth, Peter J. Schatz, Peter Young, Jennifer M. Green, Richard B. Mortensen, Karen Leu, David K. Martinez
Publikováno v:
Experimental Hematology. 42:838
68 69 70 71 72 73 74 75 76 77 78 79 80 81 Corrigendum to ‘‘Peginesatide and erythropoietin stimulate similar erythropoietin receptor–mediated signal transduction and gene induction events’’ [Experimental Hematology 40 (2012) 575–587] Jenn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cb990d568e64b43fbbe080b285c9acb
https://doi.org/10.1016/j.exphem.2014.04.003
https://doi.org/10.1016/j.exphem.2014.04.003
Autor:
Peter J. Schatz, Jennifer M. Green, Karen Leu, Peter R. Young, Rakesh Verma, Don M. Wojchowski, Richard B. Mortensen
Publikováno v:
Blood. 120:2089-2089
Abstract 2089 Peginesatide is a peptide-based erythropoietin receptor (EPOR) agonist with recent FDA approval for treating the anemia of chronic kidney disease among adult dialysis patients. Although peginesatide exhibits a 47.9h half-life when given
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::989d8835fd2f1c08b665738acf7b958b
https://doi.org/10.1182/blood.v120.21.2089.2089
https://doi.org/10.1182/blood.v120.21.2089.2089
Autor:
Richard B. Mortensen, Lynn M. Kochersperger, Lois A. Aldwin, Cynthia L. Adams, Christopher P. Holmes
Publisher Summary This chapter describes new methodologies in the preparation of peptide libraries. The photochemical synthesis of peptides is facilitated through the use of nitroveratryloxycarbonyl (Nvoc) as the protecting group for the terminal ami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9c593f33f72802f1ba18ed28e228277
https://doi.org/10.1016/b978-0-12-194710-1.50064-3
https://doi.org/10.1016/b978-0-12-194710-1.50064-3