Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Richard B. Markham"'
Autor:
James Tristan Gordy, Yinan Hui, Courtney Schill, Tianyin Wang, Fengyixin Chen, Kaitlyn Fessler, Jacob Meza, Yangchen Li, Alannah D. Taylor, Rowan E. Bates, Petros C. Karakousis, Andrew Pekosz, Jaiprasath Sachithanandham, Maggie Li, Styliani Karanika, Richard B. Markham
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
BackgroundPrevious studies have demonstrated enhanced efficacy of vaccine formulations that incorporate the chemokine macrophage inflammatory protein 3α (MIP-3α) to direct vaccine antigens to immature dendritic cells. To address the reduction in va
Externí odkaz:
https://doaj.org/article/708db69f8a054d40b2e5f6c712033389
Autor:
James T. Gordy, Avinaash K. Sandhu, Kaitlyn Fessler, Kun Luo, Aakanksha R. Kapoor, Samuel K. Ayeh, Yinan Hui, Courtney Schill, Fengyixin Chen, Tianyin Wang, Styliani Karanika, Joel C. Sunshine, Petros C. Karakousis, Richard B. Markham
Publikováno v:
Frontiers in Immunology, Vol 13 (2023)
IntroductionDNA vaccines containing a fusion of the gene encoding chemokine MIP-3α (CCL20), the ligand for CCR6 on immature dendritic cells (DCs), to melanoma-associated antigen genes have enhanced anti-tumor immunity and efficacy compared to those
Externí odkaz:
https://doaj.org/article/f580847271df43f3ba7a30b33b0a8791
Autor:
Styliani Karanika, James T. Gordy, Pranita Neupane, Theodoros Karantanos, Jennie Ruelas Castillo, Darla Quijada, Kaitlyn Comstock, Avinaash K. Sandhu, Aakanksha R. Kapoor, Yinan Hui, Samuel K. Ayeh, Rokeya Tasneen, Stefanie Krug, Carina Danchik, Tianyin Wang, Courtney Schill, Richard B. Markham, Petros C. Karakousis
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Lengthy tuberculosis (TB) treatment is required to overcome the ability of a subpopulation of persistent Mycobacterium tuberculosis (Mtb) to remain in a non-replicating, antibiotic-tolerant state characterized by metabolic remodeling, including induc
Externí odkaz:
https://doaj.org/article/9e6a0ab5a6a54babb18f999d3a442d6d
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract Infants and young children are the groups at greatest risk for severe disease resulting from Plasmodium falciparum infection. We previously demonstrated in mice that a protein vaccine composed of the chemokine macrophage inflammatory protein
Externí odkaz:
https://doaj.org/article/7485f0e900e94d07a7396823ed494a5d
Autor:
Yu-Min Chuang, Noton K. Dutta, James T. Gordy, Victoria L. Campodónico, Michael L. Pinn, Richard B. Markham, Chien-Fu Hung, Petros C. Karakousis
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The lengthy and complicated current regimen required to treat drug-susceptible tuberculosis (TB) reflects the ability of Mycobacterium tuberculosis (Mtb) to persist in host tissues. The stringent response pathway, governed by the dual (p)ppGpp synthe
Externí odkaz:
https://doaj.org/article/a2f75556b5804fcca31939cc480437d6
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 4, Iss 1 (2016)
Background Although therapeutic cancer vaccines have been mostly disappointing in the clinic, the advent of novel immunotherapies and the future promise of neoantigen-based therapies have created the need for new vaccine modalities that can easily ad
Externí odkaz:
https://doaj.org/article/3148565c53b64b5c9bd103e302f31ace
Autor:
Aakanksha Kapoor, Samuel K. Ayeh, Petros C. Karakousis, Richard B. Markham, James T. Gordy, Kun Luo, Emily S. Kim
Publikováno v:
Cancer Immunology, Immunotherapy. 69:569-580
The chemokine MIP-3α (CCL20) binds to CCR6 on immature dendritic cells. DNA vaccines fusing MIP-3α to melanoma-associated antigens have shown improved efficacy and immunogenicity in the B16F10 mouse melanoma model. Here, we report that the combinat
Autor:
Lu Yin, Zhenbang Zhou, Wei Wei, Xiao-Fang Yu, Ting Chen, Richard B. Markham, Hanchu Xiong, Jiaming Su, Rongzhen Xu, Meng Lou, Yajuan Rui, Wei Zhang, Yong Cai, Na Zhao, Si Shen, Shu Zheng, Zhengguo Zhang
Publikováno v:
Nature Microbiology. 4:2552-2564
Innate immunity is the first line of host defence against pathogens. Suppression of innate immune responses is essential for the survival of all viruses. However, the interplay between innate immunity and HIV/SIV is only poorly characterized. We have
Autor:
James T. Gordy, Kaitlyn Comstock, Avinaash K. Sandhu, Yinan Hui, Styliani Karanika, Joel Sunshine, Petros C. Karakousis, Richard B. Markham
Publikováno v:
Cancer Research. 82:LB531-LB531
Background: DNA vaccines fusing the chemokine MIP-3α (CCL20), which binds to CCR6 on immature dendritic cells (DCs), to melanoma-associated antigens have enhanced anti-tumor immunity and efficacy compared to vaccines lacking the chemokine. To furthe
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e90413 (2014)
Although sterilizing immunity to malaria can be elicited by irradiated sporozoite vaccination, no clinically practical subunit vaccine has been shown to be capable of preventing the approximately 600,000 annual deaths attributed to this infection. DN
Externí odkaz:
https://doaj.org/article/8f1d16a03d3a4da39297170ce545f007