Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Richard B. Jennett"'
Publikováno v:
Biochemical pharmacology. 44(1)
We have shown previously that acetaldehyde forms stable covalent adducts with tubulin, resulting in impaired microtubule formation. The present study explored the mechanism responsible for impaired microtubule formation caused by the substoichiometri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25784bda1956239766e922136189cf3f
https://pubmed.ncbi.nlm.nih.gov/1632840
https://pubmed.ncbi.nlm.nih.gov/1632840
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 544:144-152
The effects of phenobarbital on protein and glycoprotein synthesis and secretion were studied in rat liver slices. Phenobarbital (2 mM) decreased [14C]glucosamine and [14C]leucine incorporation into liver proteins and markedly inhibited their incorpo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1728aab839496454e85d09b40dc7a5
https://doi.org/10.1016/0304-4165(78)90218-0
https://doi.org/10.1016/0304-4165(78)90218-0
Publikováno v:
Life Sciences. 45:1461-1466
The regulatory protein, calmodulin, undergoes major conformational changes in response to changes in intracellular calcium concentration. Furthermore, calmodulin has been reported to have lysine residues which markedly increase their reactivity towar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a72996dfeb620b315328f0fb2ac5fb
https://doi.org/10.1016/0024-3205(89)90036-2
https://doi.org/10.1016/0024-3205(89)90036-2
Publikováno v:
Hepatology. 1:590-598
The effects of ethanol on the synthesis and secretion of serum glycoproteins and albumin, a nonglycosylated protein, were studied in rat liver slices. Serum glycoproteins and albumin were determined by immunoprecipitation from either the incubation m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1341ffd1931d26261b52cb97c1ab696d
https://doi.org/10.1002/hep.1840010606
https://doi.org/10.1002/hep.1840010606
Publikováno v:
Archives of Biochemistry and Biophysics. 204:181-190
Colchicine-binding properties of the total cytoplasmic pool of tubulin from rat liver were evaluated in tubulin-stabilizing (TS) supernates. Microtubules were separated from free tubulin using a microtubule-stabilizing solution (MTS) and ultracentrif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63da8137091587ada21d50501bf6532e
https://doi.org/10.1016/0003-9861(80)90022-3
https://doi.org/10.1016/0003-9861(80)90022-3
Publikováno v:
Pharmacology. 21:363-368
Ethanol, acetaldehyde, and acetate were investigated for their effects on bovine neurotubulin polymerization. Ethanol at concentrations as high as 50 mM did not affect the rate or extent of tubulin polymerization. Acetyldehyde inhibited tubulin polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81bd987dcf258d6eeef76aa6d532867
https://doi.org/10.1159/000137453
https://doi.org/10.1159/000137453
Publikováno v:
Hepatology. 7:787-789
Immunization of mice with acetaldehyde conjugated to human plasma proteins resulted in the production of polyclonal antibodies that reacted with erythrocyte protein-acetaldehyde conjugates, but not with control erythrocyte proteins. Such antibodies r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26f4ff715417e6d90fb25564eebf1fb2
https://doi.org/10.1002/hep.1840070432
https://doi.org/10.1002/hep.1840070432
Publikováno v:
Annals of the New York Academy of Sciences. 492
Acetaldehyde covalently binds to purified tubulin in vitro to form both stable and unstable adducts. The formation of stable adducts can be greatly facilitated by the inclusion of the relatively gentle and Schiff base specific reducing agent, sodium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9cc74bbca75790719662f2932289d2
https://pubmed.ncbi.nlm.nih.gov/3474930
https://pubmed.ncbi.nlm.nih.gov/3474930
Publikováno v:
Molecular and Cellular Biochemistry. 71
The effects of the microtubular inhibitor, podophyllotoxin, on mitochondrial respiration were determined using isolated, digitonin-permeabilized hepatocytes and isolated mitochondria. In hepatocytes, podophyllotoxin (1.5 mM) inhibited coupled and unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3affb216c3564cd88724c6ad47bf2db6
https://doi.org/10.1007/bf00219331
https://doi.org/10.1007/bf00219331
Publikováno v:
Archives of biochemistry and biophysics. 256(1)
The covalent binding of [14C]acetaldehyde to purified beef brain tubulin was characterized. As we have found for several other proteins, tubulin bound acetaldehyde to form both stable and unstable adducts. Unstable adducts (Schiff bases) were stabili
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ea131619917500347d08b335f5dd95c
https://pubmed.ncbi.nlm.nih.gov/3606116
https://pubmed.ncbi.nlm.nih.gov/3606116