Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Richard B. Jacobsen"'
Autor:
Michelle Grilley, David R. Hillyard, Maren Watkins, Lourdes J. Cruz, Elsie C. Jimenez, Baldomero M. Olivera, Richard B. Jacobsen
Publikováno v:
The Journal of Peptide Research. 51:173-179
We previously characterized contryphan-R, a D-tryptophan-containing octapeptide from the venom of Conus radiatus. In this study, we present evidence that the contryphan family of peptides is widely distributed in venoms of the fish-hunting cone snail
Autor:
Estuardo López-Vera, Richard B. Jacobsen, Baldomero M. Olivera, Russell W. Teichert, Michael Ellison
Publikováno v:
Toxicon. 49:1193-1199
The alpha-conotoxin family is comprised of peptides that share the following arrangement of cysteine residues in the primary amino acid sequence: -CC-C-C-, where each dash represents a variable number of amino acids. The number of amino acids between
Autor:
Russell W. Teichert, Baldomero M. Olivera, Richard B. Jacobsen, Doju Yoshikami, Heinrich Terlau
Publikováno v:
Toxicon. 49:318-328
We have characterized the defining members of a novel subfamily of excitatory conotoxins, the short kappaA-conotoxins (kappaA(S)-conotoxins). kappaA-conotoxins PIVE and PIVF (kappaA-PIVE and kappaA-PIVF) were purified from Conus purpurascens venom. B
Autor:
Marites J. Ayson, Richard B. Jacobsen, Petr Novák, Leavell, Joseph S. Schoeniger, William E. Haskins, Gary Kruppa, Malin M. Young
Publikováno v:
Analytical Chemistry. 77:5101-5106
Fourier transform tandem mass spectrometry (FT-MS/MS) can be used to unambiguously assign intramolecular chemical cross-links to specific amino acid residues even when two or more possible cross-linking sites are adjacent in the cross-linked protein.
Autor:
Baldomero M. Olivera, James E. Garrett, Gloria P. Corpuz, Wenqin Li, J. Michael McIntosh, Owen M. McDougal, David R. Hillyard, Clark Colledge, Richard B. Jacobsen, Elsie C. Jimenez, William R. Gray, Lourdes J. Cruz, Craig S. Walker, Jean Rivier, Maren Watkins
Publikováno v:
Biochemistry. 44:8176-8186
Most of the50,000 different pharmacologically active peptides in Conus venoms belong to a small number of gene superfamilies. In this work, the M-conotoxin superfamily is defined using both biochemical and molecular criteria. Novel excitatory peptide
Publikováno v:
Biochemistry. 42:6353-6362
A novel inhibitor of nicotinic acetylcholine receptors (nAChRs), psi-conotoxin Piiif, was isolated from the venom of Conus purpurascens and found to have the sequence GOOCCLYGSCROFOGCYNALCCRK-NH2. The sequence is highly homologous to that of psi-cono
Autor:
William R. Gray, J. Michael McIntosh, Kyou-Hoon Han, Jae Eun Suk, Richard B. Jacobsen, Kyu Hwan Park
Publikováno v:
Journal of Biological Chemistry. 276:49028-49033
A high resolution structure of alpha-conotoxin EI has been determined by (1)H NMR spectroscopy and molecular modeling. alpha-Conotoxin EI has the same disulfide framework as alpha 4/7 conotoxins targeting neuronal nicotinic acetylcholine receptors bu
Publikováno v:
Journal of Neurophysiology. 86:1365-1375
Thalamic slice preparations, in which intrathalamic connectivity between the reticular nucleus and relay nuclei is maintained, are capable of sustaining rhythmic burst firing activity in rodents and ferret. These in vitro oscillations occur spontaneo
Publikováno v:
Proceedings of the National Academy of Sciences. 97:3573-3578
Working memory (WM) refers to the temporary storage and processing of goal-relevant information. WM is thought to include domain-specific short-term memory stores and executive processes, such as coordination, that operate on the contents of WM. To e
Autor:
Richard B. Jacobsen, William R. Gray, Elsie C. Jimenez, Baldomero M. Olivera, Lourdes J. Cruz, R. G C De la Cruz
Publikováno v:
The Journal of Peptide Research. 54:93-99
A Conus peptide family (the contryphans) is noteworthy because of the presence of a post-translationally modified d-amino acid in all members of the family. A new contryphan peptide, Leu-contryphan-P, was isolated from the venom of Conus purpurascens