Zobrazeno 1 - 10
of 445
pro vyhledávání: '"Richard B. Rothman"'
Autor:
Tamara Antonio, Steven R Childers, Richard B Rothman, Christina M Dersch, Christine King, Martin Kuehne, William G Bornmann, Amy J Eshleman, Aaron Janowsky, Eric R Simon, Maarten E A Reith, Kenneth Alper
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77262 (2013)
The iboga alkaloids are a class of small molecules defined structurally on the basis of a common ibogamine skeleton, some of which modify opioid withdrawal and drug self-administration in humans and preclinical models. These compounds may represent a
Externí odkaz:
https://doaj.org/article/15dd1576a36a4ceaa239a8d0e66074b4
Autor:
Michael H. Baumann, Richard B. Rothman, Antonio Landavazo, Ann M. Decker, Ojas A. Namjoshi, Bruce E. Blough, John S. Partilla
Publikováno v:
Psychopharmacology. 236:915-924
RATIONALE. Novel synthetic ‘bath salt’ cathinones continue to appear on the street as abused and addictive drugs. The range of subjective experiences produced by different cathinones suggests that some compounds have primarily dopaminergic activi
Autor:
Richard B Rothman, Jean L Cadet, Christina M Dersch, Michael T McCoy, Elin Lehrmann, Kevin G Becker, Michael Bader, Natalia Alenina, Michael H Baumann
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17735 (2011)
The use of fenfluramines can increase the risk of developing pulmonary arterial hypertension (PAH) in humans, but the mechanisms responsible are unresolved. A recent study reported that female mice lacking the gene for tryptophan hydroxylase-1 (Tph1(
Externí odkaz:
https://doaj.org/article/b39313865104454697e06c4fa7fb3fa5
Publikováno v:
MedChemComm. 7:1657-1663
A series of vinylogous amphetamine analogs was synthesized and examined for their activity at biogenic amine transporters and serotonin-2 receptor (5-HT2) subtypes. (1S,3E)-1-Methyl-4-phenyl-but-3-enylamine (S-6) is a potent dual dopamine/serotonin (
Publikováno v:
Annals of the New York Academy of Sciences. 844(1)
Combined dopamine (DA) and 5-hydroxytryptamine (5-HT) releasers such as phentermine (PHEN) and fenfluramine (FEN) are reported, in open label studies, to reduce craving for alcohol and cocaine and to prevent relapse. The objective of the studies repo
Publikováno v:
European Journal of Medicinal Chemistry. 92:531-539
Racemic N-substituted -1,2,3,4,4a,9a-hexahydrobenzofuro[2,3-c]pyridin-6-ols containing cis-4aaralkyl groups were explored as probes for opioid receptors. Specifically cis-4a-phenylpropyl, -phenylbutyl, and- phenylpentyl groups coupled with widely var
Autor:
John S. Partilla, Stephen J. Kohut, Jack Bergman, David S. Jacobs, Bruce E. Blough, Richard B. Rothman
Publikováno v:
Psychopharmacology. 234(23-24)
The therapeutic potential of monoamine releasers with prominent dopaminergic effects is hindered by their high abuse liability. The present study examined the effects of several novel “norepinephrine (NE)-preferring” monoamine releasers relative
Autor:
Michael H. Baumann, John S. Partilla, Ann M. Decker, Bruce E. Blough, Richard B. Rothman, Antonio Landavazo
Publikováno v:
Psychopharmacology. 231:4135-4144
Rationale Synthetic hallucinogenic tryptamines, especially those originally described by Alexander Shulgin, continue to be abused in the USA. The range of subjective experiences produced by different tryptamines suggests that multiple neurochemical m
Publikováno v:
Journal of the American Pharmacists Association. 55:122-124
Autor:
Gina F. Marrone, Marilyn A. Huestis, Karl B. Scheidweiler, Marta Concheiro, Richard B. Rothman, Michael H. Baumann
Publikováno v:
Drug Metabolism and Disposition. 42:119-125
3,4-Methylenedioxymethamphetamine (MDMA) is a widely abused illicit drug that can cause severe and even fatal adverse effects. However, interest remains for its possible clinical applications in posttraumatic stress disorder and anxiety treatment. Pr