Zobrazeno 1 - 10
of 248
pro vyhledávání: '"Richard B, Mailman"'
Publikováno v:
Frontiers in Computational Neuroscience, Vol 18 (2024)
The question of how consciousness and behavior arise from neural activity is fundamental to understanding the brain, and to improving the diagnosis and treatment of neurological and psychiatric disorders. There is significant murine and primate liter
Externí odkaz:
https://doaj.org/article/83905e54997d49a1b9be8ddfcc867164
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract It remains unclear why β-amyloid (Aβ) plaque, a hallmark pathology of Alzheimer’s disease (AD), first accumulates cortically in the default mode network (DMN), years before AD diagnosis. Resting-state low-frequency (
Externí odkaz:
https://doaj.org/article/1416236c5ff74f99b92a1f76bc2ae743
Autor:
Leslie C. Jellen, Mechelle M. Lewis, Guangwei Du, Xi Wang, Martha L. Escobar Galvis, Stanislaw Krzyzanowski, Colt D. Capan, Amanda M. Snyder, James. R. Connor, Lan Kong, Richard B. Mailman, Patrik Brundin, Lena Brundin, Xuemei Huang
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract A growing body of evidence suggests nigral iron accumulation plays an important role in the pathophysiology of Parkinson’s disease (PD), contributing to dopaminergic neuron loss in the substantia nigra pars compacta (SNc). Converging evide
Externí odkaz:
https://doaj.org/article/fd8171bac5ce4292afc8af308235a58c
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Low doses of dopamine D1 agonists improve working memory-related behavior, but high doses eliminate the improvement, thus yielding an ‘inverted-U’ dose-response curve. This dose-dependency also occurs at the single neuron level in the prefrontal
Externí odkaz:
https://doaj.org/article/a9042f49303c4ceaa7f3708169473a6c
Autor:
Mechelle M. Lewis, Lauren J. Van Scoy, Sol De Jesus, Jonathan G. Hakun, Paul J. Eslinger, Julio Fernandez-Mendoza, Lan Kong, Yang Yang, Bethany L. Snyder, Natalia Loktionova, Sridhar Duvvuri, David L. Gray, Xuemei Huang, Richard B. Mailman
Publikováno v:
Biomolecules, Vol 13, Iss 5, p 829 (2023)
Current pharmacotherapy has limited efficacy and/or intolerable side effects in late-stage Parkinson’s disease (LsPD) patients whose daily life depends primarily on caregivers and palliative care. Clinical metrics inadequately gauge efficacy in LsP
Externí odkaz:
https://doaj.org/article/7cc757351af94200a6c84001e84bd141
Autor:
Eun-Young Lee, Juhee Kim, Janina Manzieri Prado-Rico, Guangwei Du, Mechelle M. Lewis, Lan Kong, Byoung-Gwon Kim, Young-Seoub Hong, Jeff D. Yanosky, Richard B. Mailman, Xuemei Huang
Publikováno v:
NeuroToxicology. 96:53-68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2d18afb911008a689f9df789a3bc214
https://doi.org/10.1016/j.neuro.2023.03.005
https://doi.org/10.1016/j.neuro.2023.03.005
Autor:
Jillian S. Weissenrieder, Jessie L. Reed, George‐Lucian Moldovan, Martin T. Johnson, Mohamed Trebak, Jeffrey D. Neighbors, Richard B. Mailman, Raymond J. Hohl
Publikováno v:
Pharmacology Research & Perspectives, Vol 9, Iss 3, Pp n/a-n/a (2021)
Abstract Dopamine D2‐like receptor antagonists have been suggested as being potential anticancer therapeutics with specific utility for central nervous system cancers due to their ability to cross the blood‐brain barrier. Despite a plethora of da
Externí odkaz:
https://doaj.org/article/35708c35af8346ed9b57a5f5a2acf42d
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 382:88-99
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1603fba42e78558c2641dd9e3585e582
https://doi.org/10.1124/jpet.122.001215
https://doi.org/10.1124/jpet.122.001215
Autor:
Jiaxing Chen, Yashavantha L. Vishweshwaraiah, Richard B. Mailman, Erdem D. Tabdanov, Nikolay V. Dokholyan
Publikováno v:
Science Advances. 9
Single-protein–based devices that integrate signal sensing with logical operations to generate functional outputs offer exceptional promise for monitoring and modulating biological systems. Engineering such intelligent nanoscale computing agents is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86bf7006218cb572814aac891fdbe44d
https://doi.org/10.1126/sciadv.adg1062
https://doi.org/10.1126/sciadv.adg1062
Publikováno v:
bioRxiv
The question of how consciousness and behavior arise from neural activity is fundamental to understanding the brain, and to improving the diagnosis and treatment of neurological and psychiatric disorders. There is significant literature in murine and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a42dfb5070b65280b5a84b8fe38018dd
https://europepmc.org/articles/PMC10245714/
https://europepmc.org/articles/PMC10245714/
