Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Richard Armer"'
Autor:
Caroline Phillips, Inder Bhamra, Catherine Eagle, Eimear Flanagan, Richard Armer, Clifford D. Jones, Matilda Bingham, Peter Calcraft, Alicia Edmenson Cook, Ben Thompson, Simon A. Woodcock
Publikováno v:
Cancer Research Communications. 2:914-928
Wnt signaling is implicated in the etiology of gastrointestinal tract cancers. Targeting Wnt signaling is challenging due to on-target toxicity concerns and lack of druggable pathway components. We describe the discovery and characterization of RXC00
Autor:
Simon A. Woodcock, Ben Thompson, Alicia Edmenson Cook, Peter Calcraft, Matilda Bingham, Clifford D. Jones, Richard Armer, Eimear Flanagan, Catherine Eagle, Inder Bhamra, Caroline Phillips
Supplementary Figure 1: Effect of RXC004 on gene expression, caspase activity and cell growth in colorectal and pancreatic cancer cell lines in vitro. Supplementary Figure 2: RXC004 effects on gene expression in in vivo xenograft tumor models. Supple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b6893e4d505480fc43f1898c349fe1e
https://doi.org/10.1158/2767-9764.22545548
https://doi.org/10.1158/2767-9764.22545548
Autor:
Simon A. Woodcock, Ben Thompson, Alicia Edmenson Cook, Peter Calcraft, Matilda Bingham, Clifford D. Jones, Richard Armer, Eimear Flanagan, Catherine Eagle, Inder Bhamra, Caroline Phillips
Wnt signaling is implicated in the etiology of gastrointestinal tract cancers. Targeting Wnt signaling is challenging due to on-target toxicity concerns and lack of druggable pathway components. We describe the discovery and characterization of RXC00
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d9e1e0c142eeceed8c07581b97cf0c3
https://doi.org/10.1158/2767-9764.c.6550973.v1
https://doi.org/10.1158/2767-9764.c.6550973.v1
Autor:
Simon A. Woodcock, Dorottya Keppel, Catherine Eagle, Inder Bhamra, Eleanor Platt, Lucy Frost, Kevin Randall, Richard Armer, Jane Robertson, Gayle Marshall, Caroline Phillips
Publikováno v:
Cancer Research. 83:1654-1654
Background: RXC004 is a potent and selective inhibitor of the Wnt pathway regulator Porcupine, and is currently being investigated in phase 2 studies in patients with advanced cancers, including Biliary Tract Cancers (BTCs) +/- Pembrolizumab (NCT0490
Autor:
James Kelly, Simon Woodcock, Inder Bhamra, Cliff Jones, Richard Armer, Jane Robertson, Caroline Phillips
Publikováno v:
Cancer Research. 82:2566-2566
Background: RXC004, a potent and selective inhibitor of the Wnt pathway regulator Porcupine, is being investigated in phase 2 studies in patients with advanced cancers (NCT04907851 and NCT04907539). Wnt pathway alterations, including loss-of-function
Autor:
Inder Bhamra, Richard Armer, Caroline Phillips, Andrew Saunders, Catherine Eagle, Craig Tilston, Simon Woodcock
Publikováno v:
Cancer Research. 81:998-998
Background: RXC004 is a porcupine inhibitor, and thus a potent and selective inhibitor of Wnt ligand-dependent signalling. RXC004 is currently being investigated in a safety and tolerability study in cancer patients with solid tumours (NCT03447470).
Autor:
Nicolas E. S. Guisot, Richard Armer, Inder Bhamra, Kay Eckersley, Peter Bunyard, Claire Chaplin, Caroline Phillips, Cliff Jones
Publikováno v:
Mechanisms of lung injury and repair.
Wnt signalling is strongly associated with Idiopathic Pulmonary Fibrosis (IPF) with gene expression and proteomics analysis suggesting that approximately half of all patients may exhibit enhanced pathway activation during the progression of the disea
Autor:
Matilda Bingham, P. Calcraft, J. Wright, A. Tuffnell, M.A. Campbell, Richard Armer, K. Messenger, L. Burrus, B. Thompson, Stuart A. Best, Inder Bhamra, Caroline Phillips, Valentina Abet, Louise Sargent, L. Galli
Publikováno v:
European Journal of Cancer. 69:S100-S101
Autor:
Richard Armer, Catherine Eagle, Alicia Edmenson Cook, Matilda Bingham, Simon Woodcock, Inder Bhamra, Caroline Phillips
Publikováno v:
Cancer Research. 78:3764-3764
Background: RXC004, a potent and selective porcupine (PORCN) inhibitor, is being investigated in a safety and tolerability study in cancer patients with solid tumours (CT 2017-000720-98). In addition to the tumour targeting role of RXC004 and other W
Autor:
Abhijith Thippeswamy, Matilda Bingham, Thomas Pesnot, Lucy Cartwright, Caroline Phillips, James Kelly, Sachin G. Mahale, Philip A. MacFaul, John Maclean, Richard Armer, Catherine Eagle, Aleksandr Grisin, Sheenagh Aiken, Simon Armitage
Publikováno v:
Cancer Research. 77:5581-5581
Harnessing the immune system via immune checkpoint blockade (e.g. anti PD-1, anti PD-L1, anti CTLA4) has led to fast and long lived responses in cancer patients. Response rates however are low and new treatments that enhance these rates are needed. R