Zobrazeno 1 - 10
of 227
pro vyhledávání: '"Richard Appleton"'
Autor:
Anthony G Marson, Girvan Burnside, Richard Appleton, Dave Smith, John Paul Leach, Graeme Sills, Catrin Tudur-Smith, Catrin O Plumpton, Dyfrig A Hughes, Paula R Williamson, Gus Baker, Silviya Balabanova, Claire Taylor, Richard Brown, Dan Hindley, Stephen Howell, Melissa Maguire, Rajiv Mohanraj, Philip EM Smith
Publikováno v:
Health Technology Assessment, Vol 25, Iss 75 (2021)
Background: Levetiracetam (Keppra®, UCB Pharma Ltd, Slough, UK) and zonisamide (Zonegran®, Eisai Co. Ltd, Tokyo, Japan) are licensed as monotherapy for focal epilepsy, and levetiracetam is increasingly used as a first-line treatment for generalised
Externí odkaz:
https://doaj.org/article/a6bb255ed29d423996d9ff3ae50435f9
Autor:
Kerry Woolfall, Louise Roper, Amy Humphreys, Mark D. Lyttle, Shrouk Messahel, Elizabeth Lee, Joanne Noblet, Anand Iyer, Carrol Gamble, Helen Hickey, Naomi Rainford, Richard Appleton
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background EcLiPSE (Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children) is a randomised controlled trial (RCT) in the United Kingdom. Challenges to success include the need to immediately administer an inte
Externí odkaz:
https://doaj.org/article/9de6fc605143439ba6630cea3716a379
Autor:
Girvan Burnside, Munir Pirmohamed, Anthony Guy Marson, John Paul Leach, Gus Baker, Catrin Tudur-Smith, Richard Appleton, Silviya Balabanova, Graeme Sills, Catrin Plumpton
Publikováno v:
BMJ Open, Vol 10, Iss 8 (2020)
Externí odkaz:
https://doaj.org/article/541ff5dc48e5411788ae6c76f19c71fa
Autor:
Catrin Tudur Smith, Sarah Nevitt, Duncan Appelbe, Richard Appleton, Pete Dixon, Janet Harrison, Anthony Marson, Paula Williamson, Elizabeth Tremain
Publikováno v:
Trials, Vol 18, Iss 1, Pp 1-8 (2017)
Abstract Background Demands are increasingly being made for clinical trialists to actively share individual participant data (IPD) collected from clinical trials using responsible methods that protect the confidentiality and privacy of clinical trial
Externí odkaz:
https://doaj.org/article/076194da65004335bddc8630d6edfa35
Autor:
Richard Appleton, Tony Marson
Epilepsy: The Facts is written specifically for sufferers of epilepsy and their friends and families. This easy-to-understand, evidence-based guide to epilepsy explains everything about the causes and effects of the disease, clearly and simply. The b
Publikováno v:
Anaesthesia & Intensive Care Medicine. 22:799-806
Pain, agitation and delirium are common during critical illness and are associated with many adverse consequences. A key aim of critical care is the facilitation of a calm, comfortable patient who can interact with their family and staff. Intensive c
Publikováno v:
Open access emergency medicine : OAEM. 14
Convulsive status epilepticus (CSE) is the most common neurological emergency in children and the second most common neurological emergency in adults. Mortality is low, but morbidity, including neuro-disability, learning difficulties, and a de-novo e
Autor:
Ian Wadsworth, Lisa V. Hampson, Thomas Jaki, Richard Appleton, Anthony G Marson, Graeme J. Sills
Publikováno v:
Journal of the Royal Statistical Society Series A: Statistics in Society. 183:515-534
Summary When developing a new medicine for children, the potential to extrapolate from adult efficacy data is well recognized. However, significant assumptions about the similarity of adults and children are needed for extrapolations to be biological
Autor:
Elizabeth Lee, Anand Iyer, Amy Humphreys, Carrol Gamble, Richard Appleton, Helen Hickey, Joanne Noblet, Mark D Lyttle, Shrouk Messahel, Louise Roper, Naomi Rainford, Kerry Woolfall
Publikováno v:
EMERGENCY MEDICINE JOURNAL
Emergency Medicine Journal : EMJ
Emergency Medicine Journal : EMJ
BackgroundAlternatives to prospective informed consent enable the conduct of paediatric emergency and critical care trials. Research without prior consent (RWPC) involves practitioners approaching parents after an intervention has been given and seek
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a727f999e78c76003e129ffed6ea530
Autor:
Richard Appleton, Praveen Jauhari
Publikováno v:
Paediatrics and Child Health. 28:480-487
The epilepsies of childhood are a markedly heterogeneous group of diseases with different presentations, outcomes and aetiologies. There is no single, gold-standard investigation that will unequivocally diagnose an epilepsy. The range of aetiologies