Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Richard A. Voit"'
Autor:
Richard A. Voit, Seth J. Corey
Publikováno v:
Haematologica, Vol 108, Iss 11 (2023)
Externí odkaz:
https://doaj.org/article/76cde8a9d3bc4b2ca20e94790f9f8890
Autor:
Yong Shen, Jeffrey M. Verboon, Yuannyu Zhang, Nan Liu, Yoon Jung Kim, Samantha Marglous, Satish K. Nandakumar, Richard A. Voit, Claudia Fiorini, Ayesha Ejaz, Anindita Basak, Stuart H. Orkin, Jian Xu, Vijay G. Sankaran
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Genetic mechanisms underlying fetal hemoglobin (HbF) regulation and switching are not fully understood. Here, the authors develop a single-cell genome editing functional assay to model how effects of mutation-harbouring functional elements contribute
Externí odkaz:
https://doaj.org/article/6510aaea4b7a4bf494e21f0d26b79c2e
Pathogenic BCL11A variants provide insights into the mechanisms of human fetal hemoglobin silencing.
Autor:
Yong Shen, Rick Li, Kristian Teichert, Kara E Montbleau, Jeffrey M Verboon, Richard A Voit, Vijay G Sankaran
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009835 (2021)
Increased production of fetal hemoglobin (HbF) can ameliorate the severity of sickle cell disease and β-thalassemia. BCL11A has been identified as a key regulator of HbF silencing, although its precise mechanisms of action remain incompletely unders
Externí odkaz:
https://doaj.org/article/16c4ace60f69490ea3d73aa1074950f0
Autor:
Lifei Hou, Richard A. Voit, Miho Shibamura-Fujiogi, Sophia Koutsogiannaki, Yunan Li, Yue Chen, Hongbo Luo, Vijay G. Sankaran, Koichi Yuki
Publikováno v:
Blood advances.
Neutrophils are the first-line defense immune cells against invading microbes. The bone marrow releases mature neutrophils into a circulation on a regular basis. In sepsis and other severe infections, a significant number of neutrophils is required,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5061ba27b403c46fa7035d9803cc65
https://pubmed.ncbi.nlm.nih.gov/36306384
https://pubmed.ncbi.nlm.nih.gov/36306384
Publikováno v:
Blood Adv
β2 integrins are well-known leukocyte adhesion molecules consisting of 4 members: CD11a-d. Their known biological functions range widely from leukocyte recruitment, phagocytosis, to immunological synapse formation, but the studies have been primaril
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8f1d3782bb9c2e9c5ebba9de6a7c211
https://doi.org/10.1182/bloodadvances.2020002504
https://doi.org/10.1182/bloodadvances.2020002504
Autor:
Richard A Voit, Xiaotian Liao, Blake Cohen, Myriam Armant, Elena Kamal, Mei-Mei Huang, William Clarke, David A. Williams, Akiko Shimamura, Vijay G. Sankaran
Publikováno v:
Blood. 140:986-987
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4155d8ef0112eb5ddca7a408e11cf4d1
https://doi.org/10.1182/blood-2022-165848
https://doi.org/10.1182/blood-2022-165848
Autor:
Richard A. Voit, Vijay G. Sankaran
Publikováno v:
Nature Genetics. 54:1449-1450
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::659ff26074b6117d10db99d9d0e37d74
https://doi.org/10.1038/s41588-022-01175-z
https://doi.org/10.1038/s41588-022-01175-z
Autor:
Richard A. Voit, Liming Tao, Fulong Yu, Liam D. Cato, Blake Cohen, Travis J. Fleming, Mateusz Antoszewski, Xiaotian Liao, Claudia Fiorini, Satish K. Nandakumar, Lara Wahlster, Kristian Teichert, Aviv Regev, Vijay G. Sankaran
Publikováno v:
Nature immunology.
The molecular regulation of human hematopoietic stem cell (HSC) maintenance is therapeutically important, but limitations in experimental systems and interspecies variation have constrained our knowledge of this process. Here, we have studied a rare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc08efefa5ab14d56c1d9471c20c1ac
https://pubmed.ncbi.nlm.nih.gov/36522544
https://pubmed.ncbi.nlm.nih.gov/36522544
Autor:
Richard A. Voit, Liming Tao, Fulong Yu, Liam D. Cato, Blake Cohen, Xiaotian Liao, Claudia Fiorini, Satish K. Nandakumar, Lara Wahlster, Kristian Teichert, Aviv Regev, Vijay G. Sankaran
The molecular regulation of human hematopoietic stem cell (HSC) self-renewal and maintenance is of substantial interest, but limitations in experimental systems and interspecies variation have constrained our knowledge of this process. To better disc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee19c02c5492fa70049e6ea738e324ed
https://doi.org/10.1101/2021.12.09.471942
https://doi.org/10.1101/2021.12.09.471942
Publikováno v:
Cell Stem Cell
DNA methyltransferase 3A (DNMT3A) is the most commonly mutated gene in clonal hematopoiesis (CH). Somatic DNMT3A mutations arise in hematopoietic stem cells (HSCs) many years before malignancies develop, but difficulties in comparing their impact bef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1434770d6e4f81951995510904066b21
https://doi.org/10.1016/j.stem.2020.07.011
https://doi.org/10.1016/j.stem.2020.07.011