Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Richard A. Sykes"'
Autor:
William R. Pitt, Alicia P. Higueruelo, Chris J Radoux, Anthony R. Bradley, David R. Spring, Mihaela D. Smilova, Tom L. Blundell, Richard A. Sykes, Andrew R. Leach, Brian D. Marsden, Jason C. Cole, Peter Richard Curran
Methods that survey protein surfaces for binding hotspots can help to evaluate target tractability and guide exploration of potential ligand binding regions. Fragment Hotspot Maps builds upon interaction data mined from the CSD (Cambridge Structural
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a21861b71a8b52ec26df80485edbf150
https://www.repository.cam.ac.uk/handle/1810/304045
https://www.repository.cam.ac.uk/handle/1810/304045
Publikováno v:
CrystEngComm. 20:2698-2704
With the aim to develop simple, programmatically generated, topology-based descriptors of crystal structures for application to mechanical properties prediction methods, we have developed a new geometric analysis protocol using the CSD Python API. By
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee5367befc10ebe4ef87f887b03cacf3
https://doi.org/10.1039/c8ce00454d
https://doi.org/10.1039/c8ce00454d
Publikováno v:
IEEE Transactions on Control Systems Technology. 24:979-991
This paper presents a novel automotive engine management system (EMS) calibration methodology for rapid dynamometer test-bed data collection and mapping I.C. engine controllers with significant dynamic and transient performance requirements. This pap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5562a321c414a6cbaf5953b8e0ee8d7c
https://doi.org/10.1109/tcst.2015.2476781
https://doi.org/10.1109/tcst.2015.2476781
Autor:
Jason C. Cole, Alicia P. Higueruelo, Chris J Radoux, William R. Pitt, Mihaela D. Smilova, Anthony R. Bradley, Richard A. Sykes, Peter Richard Curran, Tom L. Blundell, David R. Spring
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 75:a225-a225
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::809a068f0794ca9b4010c50b146e0bca
https://doi.org/10.1107/s0108767319097782
https://doi.org/10.1107/s0108767319097782
Publikováno v:
Acta Crystallographica Section A Foundations and Advances. 74:e341-e341
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e18088ada5fe9c1d350ba6144055bdca
https://doi.org/10.1107/s2053273318090083
https://doi.org/10.1107/s2053273318090083
Publikováno v:
Opflow. 35:12-17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::732b26e0ee49905de0a95c9c713f5cbc
https://doi.org/10.1002/j.1551-8701.2009.tb02963.x
https://doi.org/10.1002/j.1551-8701.2009.tb02963.x
Autor:
Richard Dodgson Sykes
Publikováno v:
Journal of Psychosomatic Research. 60:341-344
Objective: To examine analytically the question of whether the characterization of somatoform disorders (SFDs) in Diagnostic and Statistical Manual, Fourth Edition (DSM-IV) provides adequate grounds for classifying them as mental disorders rather tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5655bf4e35ddc9a9093465cd9f7f7f1
https://doi.org/10.1016/j.jpsychores.2006.01.018
https://doi.org/10.1016/j.jpsychores.2006.01.018
Publikováno v:
Journal of Chemical Information and Computer Sciences. 39:846-860
The selection and modification of atoms or functional groups underly many of the manipulations central to molecular modeling. It has become even more important to automate these tasks with the current prevalence of work with large databases of molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa3179109ccbfcef06552fe757b1e7c3
https://doi.org/10.1021/ci990422w
https://doi.org/10.1021/ci990422w
Autor:
Michael A. Firth, David R. Westhead, Timothy R. Auton, Bohdan Waszkowycz, Jin Li, Richard A. Sykes, Stephen Clinton Young, David E. Clark, Christopher W. Murray
Publikováno v:
Journal of Computer-Aided Molecular Design. 11:193-207
This paper describes a novel methodology, PRO_SELECT, which combines elements of structure-based drug design and combinatorial chemistry to create a new paradigm for accelerated lead discovery. Starting with a synthetically accessible template positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5b3d2e7b5d087c467858b0a99153396
https://doi.org/10.1023/a:1008094712424
https://doi.org/10.1023/a:1008094712424
Publikováno v:
Journal of Computer-Aided Molecular Design. 10:397-416
Two new computational tools, PRO_PHARMEX and PRO_SCOPE, for use in active-site-directed searching of 3D databases are described. PRO_PHARMEX is a flexible, graphics-based program facilitating the extraction of pharmacophores from the active site of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0640d1c4bb448c14e515aa44a4a193
https://doi.org/10.1007/bf00124472
https://doi.org/10.1007/bf00124472