Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Richard A. Spellman"'
Publikováno v:
Environmental and molecular mutagenesisREFERENCES. 63(5)
Genotoxicity testing guidelines require the assessment of the clastogenic and aneugenic potential of compounds. While in vitro micronucleus assays detect both types of endpoints, it requires labor-intensive microscopic scoring and does not discrimina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffe5afe939393e147485de192d67d390
https://pubmed.ncbi.nlm.nih.gov/35703118
https://pubmed.ncbi.nlm.nih.gov/35703118
Autor:
Richard A. Spellman, David Kirkland, Véronique Thybaud, Melanie Guérard, Stephen D. Dertinger, Steven M. Bryce, Andreas Zeller, Jeffrey C. Bemis, Maik Schuler, Sabrina Wilde, Elisabeth Lorge, Andreas Sutter, Ulrike Hemmann, Nina Queisser, Pekka T. Heikkinen, Derek T. Bernacki, Maria Engel
Publikováno v:
Environmental and Molecular Mutagenesis. 58:146-161
We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric analysis of detergent-liberated nuclei that are simultaneously stained with propidium iodide and labeled with fluorescent antibodies against p53, γH2AX, and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fada4cc49d4b86be27dafc87bb3b2f93
https://doi.org/10.1002/em.22083
https://doi.org/10.1002/em.22083
Autor:
Steven M, Bryce, Derek T, Bernacki, Jeffrey C, Bemis, Richard A, Spellman, Maria E, Engel, Maik, Schuler, Elisabeth, Lorge, Pekka T, Heikkinen, Ulrike, Hemmann, Véronique, Thybaud, Sabrina, Wilde, Nina, Queisser, Andreas, Sutter, Andreas, Zeller, Melanie, Guérard, David, Kirkland, Stephen D, Dertinger
Publikováno v:
Environmental and molecular mutagenesis. 58(3)
We previously described a multiplexed in vitro genotoxicity assay based on flow cytometric analysis of detergent-liberated nuclei that are simultaneously stained with propidium iodide and labeled with fluorescent antibodies against p53, γH2AX, and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7a6da3ae56952612a2a0f889c16b31da
https://pubmed.ncbi.nlm.nih.gov/28370322
https://pubmed.ncbi.nlm.nih.gov/28370322
Autor:
Jocelyn Moss, Jeffrey C. Bemis, Stephen D. Dertinger, Jared A. Mereness, Maik Schuler, Donna A. Dickinson, Richard A. Spellman, Steven M. Bryce
Publikováno v:
Environmental and Molecular Mutagenesis. 55:542-555
The specificity of in vitro mammalian cell genotoxicity assays is low, as they yield a high incidence of positive results that are not observed in animal genotoxicity and carcinogenicity tests, that is, "misleading" or "irrelevant" positives. We set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5542da99026b04064d308f3db8b1a39
https://doi.org/10.1002/em.21868
https://doi.org/10.1002/em.21868
Publikováno v:
Environmental and Molecular Mutagenesis. 55:64-69
Previous studies with TK6 cells have shown that extending the recovery period after pulse treatment allows for greater micronucleus expression for some compounds. This study explores the role of cell cycle delay in micronucleus expression after pulse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3abb6e56ac4e5b2546a4cd064c9b6ccb
https://doi.org/10.1002/em.21810
https://doi.org/10.1002/em.21810
Publikováno v:
Environmental and Molecular Mutagenesis. 54:308-316
Aneuploidy is a major cause of human reproductive failure and plays a large role in cancer. Phenolphthalein (PHT) induces tumors in rodents but its primary mechanism does not seem to be DNA damage. In heterozygous TSG-p53® mice, PHT induces lymphoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26152a86d2f05d0b3cdc226237706bd8
https://doi.org/10.1002/em.21781
https://doi.org/10.1002/em.21781
Autor:
Susan D. O'Lone, Krista L. Dobo, William C. Gunther, Richard A. Spellman, Maik Schuler, Paula A. Muehlbauer, Claudia J. Wiersch, Kelley E. Sanok
Publikováno v:
Environmental and Molecular Mutagenesis. 49:318-327
Previously, this laboratory reported on the development of a flow cytometry-based method that automates the assessment of the mitotic index (MI) and numerical chromosome changes in chemically treated cultures of human lymphocytes [Muehlbauer PA and S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fc8bcb9461ba3a6384307a40add0dfa
https://doi.org/10.1002/em.20387
https://doi.org/10.1002/em.20387
Autor:
James J. Filiano, Walter W. Noll, Alexander C. Mamourian, Arnold B. Hawk, Dorothy R. Belloni, T.K. Mohandas, John B. Moeschler, Richard A. Spellman, Jonathan P. Park
Publikováno v:
American Journal of Medical Genetics. 82:294-300
Interstitial duplications of proximal 15q containing the Prader-Willi syndrome/Angelman syndrome (PWS/AS) region have been found in patients with autism or atypical autism. In these cases with an abnormal phenotype, the duplications were maternally d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b488ca095f646cfa7ec741508d0358af
https://doi.org/10.1002/(sici)1096-8628(19990212)82:4<294::aid-ajmg4>3.0.co
https://doi.org/10.1002/(sici)1096-8628(19990212)82:4<294::aid-ajmg4>3.0.co
Autor:
Steven M, Bryce, Jeffrey C, Bemis, Jared A, Mereness, Richard A, Spellman, Jocelyn, Moss, Donna, Dickinson, Maik J, Schuler, Stephen D, Dertinger
Publikováno v:
Environmental and molecular mutagenesis. 55(7)
The specificity of in vitro mammalian cell genotoxicity assays is low, as they yield a high incidence of positive results that are not observed in animal genotoxicity and carcinogenicity tests, that is, "misleading" or "irrelevant" positives. We set
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0b49b4d6f9e3682f892f8c15f0cb7c78
https://pubmed.ncbi.nlm.nih.gov/24756928
https://pubmed.ncbi.nlm.nih.gov/24756928
Publikováno v:
Environmental and molecular mutagenesis. 55(1)
Previous studies with TK6 cells have shown that extending the recovery period after pulse treatment allows for greater micronucleus expression for some compounds. This study explores the role of cell cycle delay in micronucleus expression after pulse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a7935c3cf08dadac446d35617c488c2
https://pubmed.ncbi.nlm.nih.gov/23982927
https://pubmed.ncbi.nlm.nih.gov/23982927