Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Richard A. Slayden"'
Autor:
Helen P. Bartlett, Clinton C. Dawson, Cody M. Glickman, David W. Osborn, Christopher R. Evans, Benjamin J. Garcia, Lauren C. Frost, Jason E. Cummings, Nicholas Whittel, Richard A. Slayden, Jason W. Holder
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 5 (2024)
ABSTRACTTo address intracellular mycobacterial infections, we developed a cocktail of four enzymes that catalytically attack three layers of the mycobacterial envelope. This cocktail is delivered to macrophages, through a targeted liposome presented
Externí odkaz:
https://doaj.org/article/75c0c1c5c1174a9db6bee2933f0b4e4f
Autor:
Savannah M. Rocha, Anna C. Fagre, Amanda S. Latham, Jason E. Cummings, Tawfik A. Aboellail, Philip Reigan, Devin A. Aldaz, Casey P. McDermott, Katriana A. Popichak, Rebekah C. Kading, Tony Schountz, Neil D. Theise, Richard A. Slayden, Ronald B. Tjalkens
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Despite significant research efforts, treatment options for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remain limited. This is due in part to a lack of therapeutics that increase host defense to the virus. Replication of SARS-CoV-2
Externí odkaz:
https://doaj.org/article/042ff2a87d9a449d818ce9b18173369f
Autor:
Oxana Kazakova, Roxana Racoviceanu, Anastasiya Petrova, Marius Mioc, Adrian Militaru, Lucreția Udrescu, Mihai Udrescu, Adrian Voicu, Jason Cummings, Gregory Robertson, Diane J. Ordway, Richard A. Slayden, Codruța Șoica
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 22, p 12542 (2021)
Twenty lupane type A-ring azepano-triterpenoids were synthesized from betulin and its related derivatives and their antitubercular activity against Mycobacterium tuberculosis, mono-resistant MTB strains, and nontuberculous strains Mycobacterium absce
Externí odkaz:
https://doaj.org/article/3e7403c52ff547d18f5dcf6d20eacf42
Publikováno v:
Frontiers in Immunology, Vol 4 (2013)
Understanding the Ly49 gene family can be challenging in terms of nomenclature and genetic organization. The Ly49 gene family has two major gene nomenclature systems, Ly49 and Killer Cell Lectin-like Receptor subfamily A (klra). Mice from different s
Externí odkaz:
https://doaj.org/article/5739275104174100a4c56eb24b1cf014
Autor:
Collin M Bantle, C Tenley French, Jason E Cummings, Shankar Sadasivan, Kevin Tran, Richard A Slayden, Richard J Smeyne, Ronald B Tjalkens
Publikováno v:
PLoS ONE, Vol 16, Iss 1, p e0245171 (2021)
Infection with Influenza A virus can lead to the development of encephalitis and subsequent neurological deficits ranging from headaches to neurodegeneration. Post-encephalitic parkinsonism has been reported in surviving patients of H1N1 infections,
Externí odkaz:
https://doaj.org/article/c6f1ecacc541473c9b389152ae23b0da
Autor:
Linsen Li, Steffen Lindert, Yanran Lu, Anna Chen, Jason E. Cummings, Chelsea A Mann, Sandip Vibhute, Brieanna Roth, Anthony English, Sheri Nolan, Mark J. Mitton-Fry, Daniel J. Wozniak, Steven C Ratigan, Richard A. Slayden, Jack C. Yalowich, Bryan Koci, Antony A. Okumu, Jonathan L. Papa, Craig A. McElroy, Justin T Seffernick, Leonard R Duncan
Publikováno v:
Journal of Medicinal Chemistry. 64:15214-15249
Novel bacterial topoisomerase inhibitors (NBTIs) are among the most promising new antibiotics in preclinical/clinical development. We previously reported dioxane-linked NBTIs with potent antistaphylococcal activity and reduced hERG inhibition, a key
Publikováno v:
JAC-antimicrobial resistance. 4(2)
Background NIAID has a programme for testing drug candidates against biodefense and emerging bacterial pathogens that uses defined strain panels consisting of standard laboratory reference strains and strains of clinical origin. Objectives The curren
Autor:
Yanran, Lu, Sandip, Vibhute, Linsen, Li, Antony, Okumu, Steven C, Ratigan, Sheri, Nolan, Jonathan L, Papa, Chelsea A, Mann, Anthony, English, Anna, Chen, Justin T, Seffernick, Bryan, Koci, Leonard R, Duncan, Brieanna, Roth, Jason E, Cummings, Richard A, Slayden, Steffen, Lindert, Craig A, McElroy, Daniel J, Wozniak, Jack, Yalowich, Mark J, Mitton-Fry
Publikováno v:
Journal of medicinal chemistry. 64(20)
Novel bacterial topoisomerase inhibitors (NBTIs) are among the most promising new antibiotics in preclinical/clinical development. We previously reported dioxane-linked NBTIs with potent antistaphylococcal activity and reduced hERG inhibition, a key
Publikováno v:
JAC-Antimicrobial Resistance
Background Francisella tularensis is a highly virulent and contagious Gram-negative intracellular bacterium that causes the disease tularaemia in mammals and is classified as a Category A priority pathogen. Methods We utilized a systematic analysis o
Autor:
Savannah M. Rocha, Anna C. Fagre, Amanda S. Latham, Katriana A. Popichak, Casey P. McDermott, Clinton C. Dawson, Jason E. Cummings, Juliette Lewis, Philip Reigan, Tawfik A. Aboellail, Rebekah C. Kading, Tony Schountz, Neil D. Theise, Richard A. Slayden, Ronald B. Tjalkens
Since its initial discovery in late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the cause of COVID19, has spread worldwide and despite significant research efforts, treatment options remain limited. Replication of SARS-CoV-2 i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ad93a5416c6c7abf235bc615ce2d3f9
https://doi.org/10.1101/2021.02.20.432110
https://doi.org/10.1101/2021.02.20.432110