Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial

Autor: Allison R. Jones, Rakesh P. Patel, Marisa B. Marques, John P. Donnelly, Russell L. Griffin, Jean-Francois Pittet, Jeffrey D. Kerby, Shannon W. Stephens, Stacia M. DeSantis, John R. Hess, Henry E. Wang, John B. Holcomb, Charles E. Wade, Deborah J. del Junco, Erin E. Fox, Nena Matijevic, Jeanette Podbielski, Angela M. Beeler, Barbara C. Tilley, Sarah Baraniuk, Hongjian Zhu, Joshua Nixon, Roann Seay, Savitri N. Appana, Hui Yang, Michael O. Gonzalez, Lisa Baer, Yao-Wei W. Wang, Brittany S. Hula, Elena Espino, An Nguyen, Nicholas Pawelczyk, Kisha D. Arora-Nutall, Rishika Sharma, Jessica C. Cardenas, Elaheh Rahbar, Tyrone Burnett, David Clark, Gerald van Belle, Susanne May, Brian Leroux, David Hoyt, Judy Powell, Kellie Sheehan, Alan Hubbard, Adam P. Arkin, Jeanne Callum, Bryan A. Cotton, Laura Vincent, Timothy Welch, Tiffany Poole, Evan G. Pivalizza, Sam D. Gumbert, Yu Bai, James J. McCarthy, Amy Noland, Rhonda Hobbs, Eileen M. Bulger, Patricia Klotz, Lindsay Cattin, Keir J. Warner, Angela Wilson, David Boman, Nathan White, Andreas Grabinsky, Jennifer A. Daniel-Johnson, Mitchell J. Cohen, Rachael A. Callcut, Mary Nelson, Brittney Redick, Amanda Conroy, Marc P. Steurer, Preston C. Maxim, Eberhard Fiebig, Joanne Moore, Eireen Mallari, Peter Muskat, Jay A. Johannigman, Bryce R.H. Robinson, Richard D. Branson, Dina Gomaa, Christopher Barczak, Suzanne Bennett, Patricia M. Carey, Christopher N. Miller, Helen Hancock, Carolina Rodriguez, Kenji Inaba, Jay G. Zhu, Monica D. Wong, Michael Menchine, Kelly Katzberg, Sean O. Henderson, Rodney McKeever, Ira A. Shulman, Janice M. Nelson, Christopher W. Tuma, Cheryl Y. Matsushita, Thomas M. Scalea, Deborah M. Stein, Cynthia K. Shaffer, Christine Wade, Anthony V. Herrera, Seeta Kallam, Sarah E. Wade, Samuel M. Galvagno, Magali J. Fontaine, Janice M. Hunt, Rhonda K. Cooke, Timothy C. Fabian, Jordan A. Weinberg, Martin A. Croce, Suzanne Wilson, Stephanie Panzer-Baggett, Lynda Waddle-Smith, Sherri Flax, Karen J. Brasel, Pamela Walsh, David Milia, Allia Nelson, Olga Kaslow, Tom P. Aufderheide, Jerome L. Gottschall, Erica Carpenter, Terence O’Keeffe, Laurel L. Rokowski, Kurt R. Denninghoff, Daniel T. Redford, Deborah J. Novak, Susan Knoll, Patrick L. Bosarge, Albert T. Pierce, Carolyn R. Williams, Martin A. Schreiber, Jennifer M. Watters, Samantha J. Underwood, Tahnee Groat, Craig Newgard, Matthias Merkel, Richard M. Scanlan, Beth Miller, Sandro Rizoli, Homer Tien, Barto Nascimento, Sandy Trpcic, Skeeta Sobrian-Couroux, Marciano Reis, Adic Pérez, Susan E. Belo, Lisa Merkley, Connie Colavecchia

Publikováno v: Annals of Emergency Medicine. 73:650-661

Study objective The transfusion of older packed RBCs may be harmful in critically ill patients. We seek to determine the association between packed RBC age and mortality among trauma patients requiring massive packed RBC transfusion. Methods We analy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0026999a5da70a2cfde26fa63c27e34b
https://doi.org/10.1016/j.annemergmed.2018.09.033

Elevated Syndecan-1 after Trauma and Risk of Sepsis: A Secondary Analysis of Patients from the Pragmatic, Randomized Optimal Platelet and Plasma Ratios (PROPPR) Trial

Autor: Albert Pierce, Roann Seay, David Boman, David E. Clark, Mitchell J. Cohen, Christopher W. Tuma, John B. Holcomb, Connie Colavecchia, Shannon W. Stephens, Deborah J. Novak, Evan G. Pivalizza, Richard D. Branson, Sarah E. Wade, Angela M. Beeler, Suzanne Bennett, Amanda S. Conroy, Eireen Mallari, Bryan A. Cotton, Kenji Inaba, Eberhard W. Fiebig, Lillian S. Kao, An Nguyen, Yu Bai, Karen J. Brasel, Sean O. Henderson, Kisha D. Arora-Nutall, Savitri N. Appana, Suzanne Wilson, Elaheh Rahbar, Tiffany Poole, David Milia, Adic Pérez, Skeeta Sobrian-Couroux, Lisa A. Baer, Keir J. Warner, Deborah M. Stein, Matthias Merkel, Magali J. Fontaine, Olga Kaslow, Monica D. Wong, Tahnee Groat, Dina Gomaa, Tyrone Burnett, Samantha J. Underwood, Lindsay Cattin, Amy Noland, Janice M. Hunt, Marisa B. Marques, Deborah J. del Junco, Henry E. Wang, Rhonda Hobbs, Eileen M. Bulger, Adam P. Arkin, Sam D. Gumbert, Elena Espino, Kelly Katzberg, Carolyn Williams, Marciano Reis, Martin A. Schreiber, Samuel M. Galvagno, Lisa Merkley, Christopher Barczak, Richard M. Scanlan, Allia Nelson, Rachael A. Callcut, John R. Hess, Thomas M. Scalea, Patrick L. Bosarge, Kellie Sheehan, Yao-Wei Willa Wang, Patricia Klotz, Marc P. Steurer, Nena Matijevic, Angela Wilson, Cynthia K. Shaffer, Jay A. Johannigman, Charles E. Wade, Preston C. Maxim, James J. McCarthy, Rodney McKeever, Jeanette M. Podbielski, Jean-Francois Pittet, Tom P. Aufderheide, Jordan A. Weinberg, Nathan J. White, Lynda Waddle-Smith, Peter Muskat, Jay G. Zhu, Susan E. Belo, Helen Hancock, Stephanie Panzer-Baggett, Craig D. Newgard, Jessica C. Cardenas, Sandro Rizoli, Judy Powell, Cheryl Y. Matsushita, Susanne May, Jennifer M. Watters, Seeta Kallam, Sandy Trpcic, Daniel T. Redford, Homer Tien, Sherri Flax, Laura Vincent, Pamela Walsh, Patricia M. Carey, Carolina Rodriguez, Christopher N. Miller, Erica Carpenter, Brittany S. Hula, Erika Gonzalez Rodriguez, David B. Hoyt, Ronald Chang, Joshua Nixon, Gerald van Belle, Mary F. Nelson, Ira A. Shulman, Jerome L. Gottschall, Nicholas Pawelczyk, Barto Nascimento, Erin E. Fox, Hongjian Zhu, Michael O. Gonzalez, Joanne Moore, Jennifer A. Daniel-Johnson, Brian G. Leroux, Janice M. Nelson, Anthony V. Herrera, Timothy J. Welch, Jeanne Callum, Terence O'Keeffe, Rhonda K. Cooke, Susan Knoll, Timothy C. Fabian, Bryce R.H. Robinson, Christine Wade, Andreas Grabinsky, Laurel L. Rokowski, Jeffrey D. Kerby, Alan Hubbard, Brittney J. Redick, Shuyan Wei, Hui Yang, Barbara C. Tilley, Sarah Baraniuk, Martin A. Croce, Kurt R. Denninghoff, Beth Miller, Rishika Sharma, Michael Menchine

Publikováno v: Journal of the American College of Surgeons. 227(6)

Endotheliopathy of trauma is characterized by breakdown of the endothelial glycocalyx. Elevated biomarkers of endotheliopathy, such as serum syndecan-1 (Synd-1) ≥ 40 ng/mL, have been associated with increased need for transfusions, complications, a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6db7fbf4dccd0104387d90f5b8e3fab
https://pubmed.ncbi.nlm.nih.gov/30243993

Making thawed universal donor plasma available rapidly for massively bleeding trauma patients: experience from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial

Autor: Janice M. Nelson, Jeanette M. Podbielski, John R. Hess, Sarah Baraniuk, Ira A. Shulman, Veda Duncan, Deborah J. Novak, Marisa B. Marques, Rhonda K. Cooke, Jeannie Callum, Jerome L. Gottschall, Sandro Rizoli, Kenji Inaba, Richard M. Scanlan, John B. Holcomb, Barbara C. Tilley, Martin A. Schreiber, Eberhard W. Fiebig, Magali J. Fontaine, Jennifer A. Daniel-Johnson, Yu Bai, Erin E. Fox, Bryan A. Cotton, Patricia M. Carey, Sherri Flax

Publikováno v: Transfusion. 55:1331-1339

BACKGROUND The Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial was a randomized clinical trial comparing survival after transfusion of two different blood component ratios for emergency resuscitation of traumatic massive hemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0882dca8e96b2abd69a7cff73db00f6e
https://doi.org/10.1111/trf.13098

Making thawed universal donor plasma available rapidly for massively bleeding trauma patients: experience from the Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial

Autor: Deborah J, Novak, Yu, Bai, Rhonda K, Cooke, Marisa B, Marques, Magali J, Fontaine, Jerome L, Gottschall, Patricia M, Carey, Richard M, Scanlan, Eberhard W, Fiebig, Ira A, Shulman, Janice M, Nelson, Sherri, Flax, Veda, Duncan, Jennifer A, Daniel-Johnson, Jeannie L, Callum, John B, Holcomb, Erin E, Fox, Sarah, Baraniuk, Barbara C, Tilley, Martin A, Schreiber, Kenji, Inaba, Sandro, Rizoli, Jeanette M, Podbielski, Bryan A, Cotton, John R, Hess, Connie, Colavecchia

Publikováno v: Transfusion. 55(6)

The Pragmatic, Randomized Optimal Platelets and Plasma Ratios (PROPPR) trial was a randomized clinical trial comparing survival after transfusion of two different blood component ratios for emergency resuscitation of traumatic massive hemorrhage. Tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2f0d85147ac061119ae6f14c9544f17b
https://pubmed.ncbi.nlm.nih.gov/25858048

Precursors of N-nitrosodimethylamine in malted barley. 1. Determination of hordenine and gramine

Autor: Richard A. Scanlan, Boonthong. Poocharoen, James F. Barbour, Leonard M. Libbey

Publikováno v: Journal of Agricultural and Food Chemistry. 40:2216-2221

N-Nitrosodimethylamine (NDMA) in beer has been traced to direct-fired malt. This study separated and quantified the malt alkaloids-methyltyramine as well as the suspected precursors, hordenine and gramine. However, laboratory nitrosation of malt samp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::10aae4bc5e09092feb328e44f486e724
https://doi.org/10.1021/jf00023a033