Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Richard A. Pfuetzner"'
Autor:
Jeremy Leitz, Chuchu Wang, Luis Esquivies, Richard A. Pfuetzner, John Jacob Peters, Sergio Couoh-Cardel, Austin L. Wang, Axel T. Brunger
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114026- (2024)
Summary: Synaptic vesicle docking and priming are dynamic processes. At the molecular level, SNAREs (soluble NSF attachment protein receptors), synaptotagmins, and other factors are critical for Ca2+-triggered vesicle exocytosis, while disassembly fa
Externí odkaz:
https://doaj.org/article/e1056b181dfa43a28fe7d62ec5082454
Autor:
Nisha Gopal, Jeremy Leitz, Chuchu Wang, Luis Esquivies, Richard A. Pfuetzner, Axel T. Brunger
Publikováno v:
Current Research in Physiology, Vol 7, Iss , Pp 100121- (2024)
Synaptic vesicles specific to inhibitory GABA-releasing neurons are critical for regulating neuronal excitability. To study the specific molecular composition, architecture, and function of inhibitory synaptic vesicles, we have developed a new method
Externí odkaz:
https://doaj.org/article/676dd94ef0024c84ac2e9b4e8b0a1e30
Autor:
Klaudia Jaczynska, Luis Esquivies, Richard A. Pfuetzner, Baris Alten, Kyle D. Brewer, Qiangjun Zhou, Ege T. Kavalali, Axel T. Brunger, Josep Rizo
Publikováno v:
FEBS Open Bio, Vol 13, Iss 1, Pp 26-50 (2023)
Characterizing interactions of Synaptotagmin‐1 with the SNARE complex is crucial to understand the mechanism of neurotransmitter release. X‐ray crystallography revealed how the Synaptotagmin‐1 C2B domain binds to the SNARE complex through a so
Externí odkaz:
https://doaj.org/article/4c5a346bf0504f2d810b8e365e02f59e
Autor:
Yan Gao, Yousuf A. Khan, Weike Mo, K. Ian White, Matthew Perkins, Richard A. Pfuetzner, Josef G. Trapani, Axel T. Brunger, Teresa Nicolson
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112345- (2023)
Summary: The AAA+ NSF complex is responsible for SNARE complex disassembly both before and after membrane fusion. Loss of NSF function results in pronounced developmental and degenerative defects. In a genetic screen for sensory deficits in zebrafish
Externí odkaz:
https://doaj.org/article/fa469058d265459a95ab589acda03f97
Autor:
Qixin Chen, Mingang Hao, Lei Wang, Linsen Li, Yang Chen, Xintian Shao, Zhiqi Tian, Richard A. Pfuetzner, Qing Zhong, Axel T. Brunger, Jun-Lin Guan, Jiajie Diao
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-10 (2021)
Abstract Lysosome–autophagosome fusion is critical to autophagosome maturation. Although several proteins that regulate this fusion process have been identified, the prefusion architecture and its regulation remain unclear. Herein, we show that upo
Externí odkaz:
https://doaj.org/article/230a058ef43a4035ac804112b7b18520
Autor:
Ying Lai, Michael J. Tuvim, Jeremy Leitz, John Peters, Richard A. Pfuetzner, Luis Esquivies, Qiangjun Zhou, Barbara Czako, Jason B. Cross, Philip Jones, Burton F. Dickey, Axel T. Brunger
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The so-called primary interface between the SNARE complex and synaptotagmin-1 (Syt1) is essential for Ca2+-triggered neurotransmitter release in neuronal synapses. The interacting residues of the primary interface are conserved across different speci
Externí odkaz:
https://doaj.org/article/a5d10121e3a641d6bd7fa03f7507213a
Autor:
Sarah Sanowar, Pragya Singh, Richard A. Pfuetzner, Ingemar André, Hongjin Zheng, Thomas Spreter, Natalie C. J. Strynadka, Tamir Gonen, David Baker, David R. Goodlett, Samuel I. Miller
Publikováno v:
mBio, Vol 1, Iss 3 (2010)
ABSTRACT The type III secretion system (T3SS) is an interspecies protein transport machine that plays a major role in interactions of Gram-negative bacteria with animals and plants by delivering bacterial effector proteins into host cells. T3SSs span
Externí odkaz:
https://doaj.org/article/c5b0c9a13dc04987adec5af22be53b0f
Autor:
Kailu Yang, Chuchu Wang, Alex J. B. Kreutzberger, K. Ian White, Richard A. Pfuetzner, Luis Esquivies, Tomas Kirchhausen, Axel T. Brunger
Publikováno v:
Proceedings of the National Academy of Sciences. 120
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) introduced a relatively large number of mutations, including three mutations in the highly conserved heptad repeat 1 (HR1) region of the spike glycoprotein (S) critic
Autor:
Klaudia Jaczynska, Luis Esquivies, Richard A. Pfuetzner, Baris Alten, Kyle D. Brewer, Qiangjun Zhou, Ege T. Kavalali, Axel T. Brunger, Josep Rizo
Publikováno v:
FEBS open bioReferences.
Characterizing interactions of Synaptotagmin-1 with the SNARE complex is crucial to understand the mechanism of neurotransmitter release. X-ray crystallography revealed how the Synaptotagmin-1 C
Autor:
Kailu Yang, Chuchu Wang, Alex J. B. Kreutzberger, Ravi Ojha, Suvi Kuivanen, Sergio Couoh-Cardel, Serena Muratcioglu, Timothy J. Eisen, K. Ian White, Richard G. Held, Subu Subramanian, Kendra Marcus, Richard A. Pfuetzner, Luis Esquivies, Catherine A. Doyle, John Kuriyan, Olli Vapalahti, Giuseppe Balistreri, Tom Kirchhausen, Axel T. Brunger
Publikováno v:
bioRxiv
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge currently available COVID-19 vaccines and monoclonal antibody therapies through epitope change on the receptor binding domain of the viral spike glycoprotein. Hence, t