Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Richard A. Maier"'
Publikováno v:
BioTechniques, Vol 45, Iss 3, Pp 235-244 (2008)
The yeast two-hybrid (Y2H) system is a powerful method to identify protein-protein inter-actions (PPI) in vivo, requiring minimal prior information of the putative interactors. The time and effort required for each experiment can be significantly red
Externí odkaz:
https://doaj.org/article/1e3a66347f7a4577b37c0f26a63e3e08
Publikováno v:
The Journal of Emergency Medicine. 51:63-65
Background Hook of the hamate fractures are particularly rare carpal fractures with significant morbidity if not diagnosed early. Classically, these fractures occur from localized blunt trauma to the hook of the hamate in racket sports. Common compla
Autor:
Jacques Schrenzel, Patrice Francois, Alexandra Dangel, Kamil Önder, Jan Pané-Farré, Carsten W. Müller, Christian Lindermayr, Jürgen Heesemann, Susanne Engelmann, Nikolaus Ackermann, Omar Abdel-Hadi, Richard H. Maier
Publikováno v:
FASEB Journal, Vol. 27, No 11 (2013) pp. 4476-88
Antimicrobial peptides are a promising complement to common antibiotics, development of resistance to which is a growing problem. Here we present a de novo-designed peptide, SP1-1 (RKKRLKLLKRLL-NH2), with antimicrobial activity against multiresistant
Autor:
Helmut Hintner, Johann W. Bauer, Richard H. Maier, Raphaela Rid, Harald Hundsberger, Julia Herzog, Andreas Eger, Kamil Önder
Publikováno v:
ASSAY and Drug Development Technologies. 11:269-275
The yeast two-hybrid (Y2H) system is one of the most technically straightforward, effective, and widely used tools for the discovery of the binary peptide or protein interactions. However, its exceptional detection sensitivity poses a serious challen
Autor:
Johann W. Bauer, Omar Abdel-Hadi, Harald Hundsberger, Martin Wagner, Richard H. Maier, Kamil Önder, Raphaela Rid, Helmut Hintner
Publikováno v:
ASSAY and Drug Development Technologies. 11:52-57
Recombination-based cloning techniques have in recent times facilitated the establishment of genome-scale single-gene ORFeome repositories. Their further handling and downstream application in systematic fashion is, however, practically impeded becau
Publikováno v:
Methods. 58:376-384
Many functional proteomic experiments make use of high-throughput technologies such as mass spectrometry combined with two-dimensional polyacrylamide gel electrophoresis and the yeast two-hybrid (Y2H) system. Currently there are even automated versio
Autor:
M. Haim, Helmut Hintner, Verena Wally, Johann W. Bauer, Andrea Trost, Herbert A. Reitsamer, Kamil Önder, P. Desch, Richard H. Maier
Publikováno v:
Mechanisms of Ageing and Development. 131:346-353
Keratin filaments form obligatory heterodimers consisting of one type I and one type II keratin that build the intermediate filaments. In keratinocytes, type II keratin 6 (K6) interacts with type I keratin 16 (K16). We previously showed that the inte
Publikováno v:
Infection and Immunity. 66:4537-4540
Lymph node cells of BALB/c mice with progressive leishmaniasis produced sixfold more interleukin-2 (IL-2) in culture than those of healing C57BL/6 mice. IL-2 synthesis also increased in C57BL/6 mice made susceptible by IL-12 or gamma interferon defic
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1061
The specific regions on proteins which are responsible for protein-protein interaction are called interacting domains, or epitopes in case of antigen-antibody binding. These domains are one feature to characterize proteins and are important in clinic
Autor:
Frederick J. Monsma, Terry Roemer, Nicholas Murgolo, Paul Mann, Li Xiao, Brad Sherborne, Richard H. Maier, Christine Yang, Stacia Kargman, Amy M. Flattery, Hao Wang, Charles Gill, Todd A. Black, Tanja Schneider, Anna Müller, Sang Ho Lee, Christopher M. Tan, Xinwei She, Margarida Moreira dos Santos, Marc A. Labroli, Kamil Önder, Joanna Trzeciak, Mariana G. Pinho, Pedro M. Pereira, Carl J. Balibar, Jing Su, Jonathan Schneeweis
Publikováno v:
ACS Chemical Biology
Modern medicine is founded on the discovery of penicillin and subsequent small molecules that inhibit bacterial peptidoglycan (PG) and cell wall synthesis. However, the discovery of new chemically and mechanistically distinct classes of PG inhibitors