Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Richard A. Macia"'
Autor:
Mauricio J. Reginato, Richard A. Macia, Caroline H. Gochoco, Gregory A. Christensen, Choon K. Oh, Jayesh Vora
Publikováno v:
Journal of Controlled Release. 24:193-200
Growth hormone releasing peptide (GHRP-6) is a synthetic hexapeptide that stimulates the release of growth hormone in several animal species. The feasibility of developing an efficacious intranasal formulation of GHRP-6 is currently under considerati
Autor:
Nabil Hanna, Robert A. Gabel, G. K. Campbell, Richard A. Macia, Michael J. DiMartino, Anthony C. Silver
Publikováno v:
Toxicology and Applied Pharmacology. 102:117-127
SK&F 101926, a synthetic peptide, is a potent antagonist of vasopressin at both the V2 and the V1 receptors. Following intravenous administration of SK&F 101926 (5 mg/kg), mean arterial pressure (MAP) immediately fell 75 mm Hg. Heart rate increased a
Autor:
P J Bugelski, D M Williams, T K Hart, Danuta J. Herzyk, S Rehm, Richard A. Macia, Allen G. Harmsen, A. Truneh, D G Morgan, E V Gore, A M Badger, B E Maleeff, Patrick J. Wier, S R O'Brien
Publikováno v:
Humanexperimental toxicology. 19(4)
The preclinical safety assessment of biopharmaceuticals necessitates that studies be conducted in species in which the products are pharmacologically active. Monoclonal anti-bodies are a promising class ofbiopharmaceuticals for many disease indicatio
Autor:
Thomas W. Beck, Amanda L. Hickman, Richard A. Macia, Derek J. Leishman, C. Michael Foley, Elaine M. Miller
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 64:e36
Publikováno v:
Desmopressin in Bleeding Disorders ISBN: 9781461362685
The first recorded use of the antidiuretic (V2) activity of pituitary extracts to treat polyuria was in 1913 (Heller 1974). Forty years later, the structure of the antidiuretic hormone, arginine vasopressin (AVP), was established (Acher and Chauvet,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d16ea9fa0e423241a424e215e25a89d2
https://doi.org/10.1007/978-1-4615-2922-4_9
https://doi.org/10.1007/978-1-4615-2922-4_9
Publikováno v:
Toxicology and applied pharmacology. 104(3)
Growth-hormone-releasing peptide (GH-RP-6) is a synthetic hexapeptide that selectively releases growth hormone (GH) when administered to a number of animals species. In the rat, maximal GH release occurs after intravenous administration of 100 microg
In vivo and in vitro cardiotoxicity of a gold-containing antineoplastic drug candidate in the rabbit
Autor:
Glenn F. Rush, G D Hoke, William D. Matthews, Christopher K. Mirabelli, Peter J. Bugelski, Richard A. Macia, Paul C. Meunier
Publikováno v:
Toxicology and Applied Pharmacology. 100:293-306
Bis[1,2-bis(diphenylphosphino)ethane] gold(I) chloride (Au(DPPE) 2 + ), a cytotoxic antineoplastic drug candidate, was cardiotoxic in rabbits. Intravenous administration of Au(DPPE) 2 + (15 mg/kg) as a single dose produced multiple, 2- to 5-mm subend
Publikováno v:
Drug Development Research. 9:213-218
SK&F 86466, 6-chloro-3-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine, is a potent and selective antagonist of the α2-adrenoceptor in vitro. This compound produced a small pressor response accompanied by a marked bradycardia when administered i.v. to t
Autor:
Afroditi Poyatzi, Richard A. Macia, Paschalio‐Adam Molyvdas, William D. Matthews, Nicholas Sperelakis
Publikováno v:
Drug Development Research. 11:197-207
The cardiac effects of SK&F 86466, an α2-adrenoceptor antagonist currently under evaluation in humans as an antihypertensive agent, were investigated in rabbits. In the isolated working rabbit heart, SK&F 86466 had no effect on spontaneous heart rat
Publikováno v:
Toxicologic Pathology. 17:203-213
Fenoldopam mesylate (FM), a selective post-junctional dopaminergic (DA1) vasodilator, causes lesions of large caliber splanchnic arteries (100–800 μm) in the rat characterized by necrosis of medial smooth muscle cells and hemorrhage. FM does not i