Výsledky vyhledávání - "Richard A. Luben"

An N-terminal splice variant of human Stat5a that interacts with different transcription factors is the dominant form expressed in invasive ductal carcinoma

Autor: Peizhi Tang, Richard A. Luben, KuanHui E. Chen, Ameae M. Walker, Changhui Deng, Dunyong Tan, Jianjun Huang, Trina Mansour

Publikováno v: Cancer letters, vol 346, iss 1

We have identified a new variant of human Stat5a, found at higher ratios to full-length Stat5a in invasive ductal carcinoma versus contiguous normal tissue. The variant, missing exon 5, inhibits p21 and Bax production and increases cell number. After

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe76e54fe5400eda20a37d4e913a3d5
https://escholarship.org/uc/item/0nz070dd

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Effects of prolactin on osteoblast alkaline phosphatase and bone formation in the developing rat

Autor: Xiaolei Xu, Richard A. Luben, Djurdjica Coss, Ameae M. Walker, Lili Yang, Chiaoyun Benson Kuo

Publikováno v: Europe PubMed Central

The purpose of the current study was to determine whether maternal prolactin (PRL) had any effects on bone formation in the developing rat pup. Because the most prevalent forms of PRL in rats are unmodified and phosphorylated PRL, both recombinant PR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::767052c15d4703e6973b508887c629f6
https://doi.org/10.1152/ajpendo.2000.279.6.e1216

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Dissociation of Janus Kinase 2 and Signal Transducer and Activator of Transcription 5 Activation after Treatment of Nb2 Cells with a Molecular Mimic of Phosphorylated Prolactin1

Autor: Lili Yang, Ameae M. Walker, Chiaoyun Benson Kuo, Patricia M. Ingleton, Richard A. Luben, Djurdjica Coss

Publikováno v: Endocrinology. 140:5087-5094

We have previously demonstrated that phosphorylated PRL acts as an antagonist to the Nb2 proliferative activities of unmodified PRL. A molecular mimic of phosphorylated PRL, which substitutes an aspartate residue for the normally phosphorylated serin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e3133841f84630ab55c7beec747eb5ab
https://doi.org/10.1210/endo.140.11.7104

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Exposure of B-lineage Lymphoid Cells to Low Energy Electromagnetic Fields Stimulates Lyn Kinase

Autor: Tomohiro Kurosaki, Joseph B. Bolen, Minoru Takata, Andre Morgan, Richard A. Luben, Xiao Jun, Jizhong Jin, Fatih M. Uckun

Publikováno v: Journal of Biological Chemistry. 270:27666-27670

Here, we present evidence that exposure of B-lineage lymphoid cells to low energy electromagnetic fields (EMF) stimulates the protein tyrosine kinases Lyn and Syk, results in tyrosine phosphorylation of multiple electrophoretically distinct substrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7180ac5a00711b56171fd879bd9b2604
https://doi.org/10.1074/jbc.270.46.27666

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Redistribution of Calbindin-D28kin Chick Intestine in Response to Calcium Transport*

Autor: Bonnie S. Thompson, Richard A. Luben, Anthony W. Norman, V. Leathers, Ilka Nemere

Publikováno v: Endocrinology. 129:2972-2984

Vitamin D and its hormonally active metabolite 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] are known to alter several parameters associated with stimulated intestinal Ca2+ transport: levels of calbindin-D28K, tubulin, and endosomal-lysosomal organelles c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1007df4383e64492eac7f1472a42ff24
https://doi.org/10.1210/endo-129-6-2972

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Effects of Low-energy Electromagnetic Fields (Pulsed and DC) on Membrane Signal Transduction Processes in Biological Systems

Autor: Richard A. Luben

Publikováno v: Health Physics. 61:15-28

The vertebrate organism possesses a number of internal processes for signaling and communication between cell types. Hormones and neurotransmitters move from one cell type to another and carry chemical "messages" that modulate the metabolic responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb2340d8f08bd47d6199ba0e0a71c47
https://doi.org/10.1097/00004032-199107000-00002

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Prolactin blocks nuclear translocation of VDR by regulating its interaction with BRCA1 in osteosarcoma cells

Autor: Richard A. Luben, Anthony W. Norman, Changhui Deng, Eric Ueda, Craig M. Bula, KuanHui E. Chen, Ameae M. Walker

Publikováno v: Molecular endocrinology (Baltimore, Md.). 23(2)

Based on their content of prolactin receptors, osteosarcoma cells were predicted to be responsive to prolactin (PRL), but whether PRL would be beneficial or contribute to pathogenesis was unclear. 1,25(OH)(2) vitamin D(3) [1alpha,25(OH)(2)D(3)] has a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d115a20a0dd08c736bbb9471b08c38db
https://pubmed.ncbi.nlm.nih.gov/19074549

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Effects of Extremely Low Frequency EMF on Signal Transduction Pathways in Vitro

Autor: Richard A. Luben

Publikováno v: Electricity and Magnetism in Biology and Medicine ISBN: 9781461372080

Signals from the environment, whether they are physical, chemical, or hormonal, regulate intracellular metabolic processes such as enzyme activities, gene expression, differentiation, and cell proliferation. The metabolic mechanisms by which cells se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::060ddb74f663b846c62788926d94f0d3
https://doi.org/10.1007/978-1-4615-4867-6_5

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Stimulation of Src family protein-tyrosine kinases as a proximal and mandatory step for SYK kinase-dependent phospholipase Cgamma2 activation in lymphoma B cells exposed to low energy electromagnetic fields

Autor: Dong Tuong, Richard A. Luben, David Pond, Lisa Tuel-Ahlgren, Alice Chu, Ilker Dibirdik, Tomohiro Kurosaki, Daiva Kristupaitis, Fatih M. Uckun

Publikováno v: The Journal of biological chemistry. 273(7)

Here, we present evidence that exposure of DT40 lymphoma B cells to low energy electromagnetic field (EMF) results in a tyrosine kinase-dependent activation of phospholipase Cgamma2 (PLC-gamma2) leading to increased inositol phospholipid turnover. B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c283f3141d0c425fd874efddce5c96d
https://pubmed.ncbi.nlm.nih.gov/9461594

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