Zobrazeno 1 - 10
of 111
pro vyhledávání: '"Richard A. Kroczek"'
Autor:
Cornelia Fischer, Michael W. Munks, Ann B. Hill, Richard A. Kroczek, Stefan Bissinger, Verena Brand, Martina Schmittnaegel, Sabine Imhof-Jung, Eike Hoffmann, Frank Herting, Christian Klein, Hendrik Knoetgen
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
Simulating a viral infection in tumor cells is an attractive concept to eliminate tumor cells. We previously reported the molecular design and the in vitro potency of recombinant monoclonal antibodies fused to a virus-derived peptide MHC class I comp
Externí odkaz:
https://doaj.org/article/906184eb45f44cc1b0adba53618c102c
Autor:
Arthur L. Kroczek, Evelyn Hartung, Stephanie Gurka, Martina Becker, Nele Reeg, Hans W. Mages, Sebastian Voigt, Christian Freund, Richard A. Kroczek
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
XCL1 is the ligand for XCR1, a chemokine receptor uniquely expressed on cross-presenting dendritic cells (DC) in mouse and man. We are interested in establishing therapeutic vaccines based on XCL1-mediated targeting of peptides or proteins into these
Externí odkaz:
https://doaj.org/article/91c6b03fd50148cc873241d3a65aaa94
Autor:
Dana Vu Van, Katja C. Beier, Lea-Jean Pietzke, Maysun S. Al Baz, Randi K. Feist, Stephanie Gurka, Eckard Hamelmann, Richard A. Kroczek, Andreas Hutloff
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
In secondary lymphoid organs T follicular helper (Tfh) cells help B cells to develop into memory B and plasma cells. Here, the authors show that inflamed lung becomes a reservoir of activated B cells with a germinal centre phenotype, and T cells that
Externí odkaz:
https://doaj.org/article/745dc794203e438ea935aca0e77d92d9
Publikováno v:
Frontiers in Immunology, Vol 6 (2015)
Since the identification of mouse dendritic cells (DC) in the early 70s, all attempts to consistently classify the identified functional DC subpopulations according to their surface molecule expression failed. In the absence of DC lineage markers, a
Externí odkaz:
https://doaj.org/article/b4d62191ecf3439fa1983d2953b3fe51
Autor:
Georgina N. Montagna, Macarena Beigier-Bompadre, Martina Becker, Richard A. Kroczek, Stefan H. E. Kaufmann, Kai Matuschewski
Publikováno v:
mBio, Vol 5, Iss 4 (2014)
ABSTRACT Protective immunity against preerythrocytic malaria parasite infection is difficult to achieve. Intracellular Plasmodium parasites likely minimize antigen presentation by surface-expressed major histocompatibility complex class I (MHC-I) mol
Externí odkaz:
https://doaj.org/article/4a9993b03a1a4476a85eedf8a593ce32
Autor:
Martina eBecker, Steffen eGüttler, Annabell eBachem, Evelyn eHartung, Ahmed eMora, Anika eJäkel, Andreas eHutloff, Volker eHenn, Hans Werner Mages, Stephanie eGurka, Richard A. Kroczek
Publikováno v:
Frontiers in Immunology, Vol 5 (2014)
In the past, lack of lineage markers confounded the classification of dendritic cells (DC) in the intestine and impeded a full understanding of their location and function. We have recently shown that the chemokine receptor XCR1 is a lineage marker f
Externí odkaz:
https://doaj.org/article/8078b4cb3e834aec9401409b974acf26
Autor:
Annabell eBachem, Evelyn eHartung, Steffen eGüttler, Ahmed eMora, Xuefei eZhou, Anika eHegemann, Maud ePlantinga, Elisa eMazzini, Patrizia eStoitzner, Stephanie eGurka, Volker eHenn, Hans W Mages, Richard A. Kroczek
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
Cross-presentation of antigen by dendritic cells (DCs) to CD8+ T cells is a fundamentally important mechanism in the defense against pathogens and tumors. Due to the lack of an appropriate lineage marker, cross-presenting DCs in the mouse are provisi
Externí odkaz:
https://doaj.org/article/f8fee15c4fc241bb8b1863269f18d105
Autor:
Richard A. Kroczek, Volker eHenn
Publikováno v:
Frontiers in Immunology, Vol 3 (2012)
Recently, the chemokine receptor XCR1 has been found to be exclusively expressed on a subset of DC known to be involved in antigen cross-presentation. This review aims to summarize the known biology of the XCR1 receptor and its chemokine ligand XCL1,
Externí odkaz:
https://doaj.org/article/a1d8519a72b84c44a713b7cca969731e
Autor:
Eike Hoffmann, Cornelia Fischer, Ann B. Hill, Martina Schmittnaegel, Stefan Bissinger, Michael W. Munks, Hendrik Knoetgen, Christian Klein, Richard A. Kroczek, Frank Herting, Sabine Imhof-Jung, Verena Brand
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Simulating a viral infection in tumor cells is an attractive concept to eliminate tumor cells. We previously reported the molecular design and the in vitro potency of recombinant monoclonal antibodies fused to a virus-derived peptide MHC class I comp
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 59:437-447
B-cell interaction with follicular helper T cells and subsequent differentiation of B cells into high-affinity APCs normally takes place in secondary lymphoid organs. The costimulator ICOS plays a key role in this process and is therefore considered