Zobrazeno 1 - 10 of 331 pro vyhledávání: '"Richard A. Kay"'
2
Akademický článek
Motilin fluctuations in healthy volunteers determined by liquid chromatography mass spectrometry
Autor: Rachel E. Foreman, Christopher A. Bannon, Richard G. Kay, Frank Reimann, Fiona M. Gribble
Publikováno v: Frontiers in Endocrinology, Vol 15 (2024)
IntroductionMotilin is a hormone secreted by specialised enteroendocrine cells in the small intestine, and is known to modulate gastrointestinal motility in humans, regulating the migratory motor complex. It is understudied at least in part due to th
Externí odkaz: https://doaj.org/article/7a08dd0a587d436180ed385259c9be65
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3
Akademický článek
Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice – Identification of selective stimuli for insulin-like peptide-5 and glucagon-like peptide-1 co-expressing cells
Autor: Lawrence J. Billing, Pierre Larraufie, Jo Lewis, Andrew Leiter, Joyce Li, Brian Lam, Giles SH. Yeo, Deborah A. Goldspink, Richard G. Kay, Fiona M. Gribble, Frank Reimann
Publikováno v: Molecular Metabolism, Vol 29, Iss , Pp 158-169 (2019)
Objective: Enteroendocrine cells (EECs) of the large intestine, found scattered in the epithelial layer, are known to express different hormones, with at least partial co-expression of different hormones in the same cell. Here we aimed to categorize
Externí odkaz: https://doaj.org/article/880adfcb0c684885b7974b0937ab2141
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4
Akademický článek
Labeling and Characterization of Human GLP-1-Secreting L-cells in Primary Ileal Organoid Culture
Autor: Deborah A. Goldspink, Van B. Lu, Emily L. Miedzybrodzka, Christopher A. Smith, Rachel E. Foreman, Lawrence J. Billing, Richard G. Kay, Frank Reimann, Fiona M. Gribble
Publikováno v: Cell Reports, Vol 31, Iss 13, Pp 107833- (2020)
Summary: Glucagon-like peptide-1 (GLP-1) from intestinal L-cells stimulates insulin secretion and reduces appetite after food ingestion, and it is the basis for drugs against type-2 diabetes and obesity. Drugs targeting L- and other enteroendocrine c
Externí odkaz: https://doaj.org/article/afe639a516f74f0cacef5f0a9acfdb57
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5
Akademický článek
Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis
Autor: Peter Kirwan, Richard G. Kay, Bas Brouwers, Vicente Herranz-Pérez, Magdalena Jura, Pierre Larraufie, Julie Jerber, Jason Pembroke, Theresa Bartels, Anne White, Fiona M. Gribble, Frank Reimann, I. Sadaf Farooqi, Stephen O'Rahilly, Florian T. Merkle
Publikováno v: Molecular Metabolism, Vol 17, Iss , Pp 82-97 (2018)
Objective: The lack of pro-opiomelanocortin (POMC)-derived melanocortin peptides results in hypoadrenalism and severe obesity in both humans and rodents that is treatable with synthetic melanocortins. However, there are significant differences in POM
Externí odkaz: https://doaj.org/article/a61f42e653954d9a945781cd864e4404
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6
Akademický článek
Co-storage and release of insulin-like peptide-5, glucagon-like peptide-1 and peptideYY from murine and human colonic enteroendocrine cells
Autor: Lawrence J. Billing, Christopher A. Smith, Pierre Larraufie, Deborah A. Goldspink, Sam Galvin, Richard G. Kay, Jonathan D. Howe, Ryan Walker, Mihai Pruna, Leslie Glass, Ramona Pais, Fiona M. Gribble, Frank Reimann
Publikováno v: Molecular Metabolism, Vol 16, Iss , Pp 65-75 (2018)
Objective: Insulin-like peptide-5 (INSL5) is an orexigenic gut hormone found in a subset of colonic and rectal enteroendocrine L-cells together with the anorexigenic hormones glucagon-like peptide-1 (GLP-1) and peptideYY (PYY). Unlike GLP-1 and PYY,
Externí odkaz: https://doaj.org/article/15266b662de9491591e17a5aadc4ad21
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10
Akademický článek
First record of the Miocene hominoid Sivapithecus from Kutch, Gujarat state, western India.
Autor: Ansuya Bhandari, Richard F Kay, Blythe A Williams, Brahma Nand Tiwari, Sunil Bajpai, Tobin Hieronymus
Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0206314 (2018)
Hominoid remains from Miocene deposits in India and Pakistan have played a pivotal role in understanding the evolution of great apes and humans since they were first described in the 19th Century. We describe here a hominoid maxillary fragment preser
Externí odkaz: https://doaj.org/article/665297552929476d90de9ba9608f34f6
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